Results 1 to 10 of about 2,707 (133)

Phrenic motor neuron loss in aged rats [PDF]

Journal of Neurophysiology, 2018
Sarcopenia is the age-related reduction of muscle mass and specific force. In previous studies, we found that sarcopenia of the diaphragm muscle (DIAm) is evident by 24 mo of age in both rats and mice and is associated with selective atrophy of type IIx and IIb muscle fibers and a decrease in maximum specific force. These fiber type-specific effects of
Matthew J Fogarty, Wen-Zhi Zhan, CARLOS B Mantilla   +2 more
exaly   +7 more sources

Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window [PDF]

Frontiers in Neural Circuits, 2023
Phrenic Motor Column (PMC) neurons are a specialized subset of motor neurons (MNs) that provide the only motor innervation to the diaphragm muscle and are therefore essential for survival.
Alicia N. Vagnozzi, Matthew T. Moore, Raquel López de Boer, Aambar Agarwal, Niccolò Zampieri, Lynn T. Landmesser, Polyxeni Philippidou   +6 more
doaj   +4 more sources

Phrenic motor neuron survival below cervical spinal cord hemisection [PDF]

Experimental Neurology, 2021
Cervical spinal cord injury (cSCI) severs bulbospinal projections to respiratory motor neurons, paralyzing respiratory muscles below the injury. C2 spinal hemisection (C2Hx) is a model of cSCI often used to study spontaneous and induced plasticity and breathing recovery post-injury.
Latoya L Allen, Nicole L Nichols, Gordon S Mitchell   +2 more
exaly   +4 more sources

Glutamatergic input varies with phrenic motor neuron size [PDF]

Journal of Neurophysiology, 2019
Like all skeletal muscles, the diaphragm muscle accomplishes a range of motor behaviors by recruiting different motor unit types in an orderly fashion. Recruitment of phrenic motor neurons (PhMNs) is generally assumed to be based primarily on the intrinsic properties of PhMNs with an equal distribution of descending excitatory inputs to all PhMNs ...
Sabhya Rana, CARLOS B Mantilla, Gary C Sieck   +2 more
exaly   +4 more sources

Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size [PDF]

Molecular and Cellular Neurosciences, 2023
Brain derived neurotrophic factor (BDNF) signalling through its high-affinity tropomyosin receptor kinase B (TrkB) is known to have potent effects on motor neuron survival and morphology during development and in neurodegenerative diseases. Here, we employed a novel 1NMPP1 sensitive TrkBF616 rat model to evaluate the effect of 14 days inhibition of ...
Matthew J Fogarty, Debanjali Dasgupta, Obaid U Khurram   +2 more
exaly   +4 more sources

Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation [PDF]

Experimental Neurology, 2017
Phrenic long-term facilitation (pLTF) is a form of hypoxia-induced spinal respiratory motor plasticity that requires new synthesis of brain derived neurotrophic factor (BDNF) and activation of its high-affinity receptor, tropomyosin receptor kinase B (TrkB).
Erica A Dale, Daryl P Fields, Gordon S Mitchell   +2 more
exaly   +5 more sources

Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCs [PDF]

Bio-Protocol
The fatal motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of the phrenic MNs (phMNs) controlling the activity of the diaphragm, leading to death by respiratory failure.
Louise Thiry, Julien Sirois, Thomas Durcan, Stefano Stifani   +3 more
doaj   +4 more sources

Aging affects the number and morphological heterogeneity of rat phrenic motor neurons and phrenic motor axons

Physiological Reports, 2023
Diaphragm muscle (DIAm) motor units comprise a phrenic motor neuron (PhMN), the phrenic nerve and the muscle fibers innervated, with the size of PhMNs and axons characteristic of motor unit type.
Matthew J. Fogarty, Gary C. Sieck
doaj   +3 more sources

Phrenic motor neuron adenosine 2A receptors elicit phrenic motor facilitation [PDF]

Journal of Physiology, 2018
Key points Although adenosine 2A (A2A) receptor activation triggers specific cell signalling cascades, the ensuing physiological outcomes depend on the specific cell type expressing these receptors. Cervical spinal adenosine 2A (A2A) receptor activation elicits a prolonged facilitation in phrenic nerve activity, which was nearly abolished following ...
Yasin B Seven, Raphaël R Perim, Arash Tadjalli   +2 more
exaly   +3 more sources

Phrenic motor neuron loss in an animal model of early onset hypertonia.

J Neurophysiol, 2020
Phrenic motor neuron (PhMN) development in early onset hypertonia is poorly understood. Yet, respiratory disorders are a common cause of morbidity and mortality. In spa mice, an animal model of early onset hypertonia, we found ~30% fewer PhMNs, compared with controls. This PhMN loss disproportionately affected larger PhMNs.
Brandenburg JE, Fogarty MJ, Brown AD, Sieck GC.   +3 more
europepmc   +7 more sources