Results 21 to 30 of about 326 (161)

Accelerated Generation of Extra-Islet Insulin-Producing Cells in Diabetic Rats, Treated with Sodium Phthalhydrazide. [PDF]

Int J Mol Sci, 2022
β-cells dysfunction plays an important role in the pathogenesis of type 2 diabetes (T2D), partially may be compensated by the generation of extra-islet insulin-producing cells (IPCs) in pancreatic acini and ducts. Pdx1 expression and inflammatory level are suggested to be involved in the generation of extra-islet IPCs, but the exact reasons and ...
Abidov MT, Sokolova KV, Gette IF, Danilova IG.   +3 more
europepmc   +3 more sources

Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

Asian Journal of Organic Chemistry, Volume 12, Issue 8, August 2023., 2023
This review provides a summary of electrosynthesis methods that can be used as an alternative method for synthesis of complex organic molecules in pharmaceutical and biological applications. This method involves electro‐organic reactions occurring at room temperature and normal pressure through transferring electrons.
Sahar Imeni, Ata Makarem, Ramin Javahershenas   +2 more
wiley   +1 more source

Different Synthetic Methods for the Preparation of Triazolopyrimidines and their Biological Profile

ChemistrySelect, Volume 8, Issue 23, June 20, 2023., 2023
This review aims to give a broad overview of the synthetic methods, starting from aminotriazoles and pyrimidines, leading to heterocyclic systems containing the triazolopyrimidine ring and presenting the reactivity of these derivatives. Additionally, we have summarized the most important biological activities.
Achraf Hibot, Asmaa Oumessaoud, Abderrafia Hafid, Mostafa Khouili, Maria Dolors Pujol   +4 more
wiley   +1 more source

In vitro Leishmanicidal and Trypanosomicidal Properties of Imidazole‐Containing Azine and Benzoazine Derivatives

ChemMedChem, Volume 16, Issue 23, Page 3600-3614, December 6, 2021., 2021
Eighteen new compounds active against different Leishmania species and Trypanosoma cruzi have been synthesized. All of them show improved in vitro efficiency and lower toxicity than Glucantime and Benznidazole, reliying their activity in their Fe‐SOD inhibitory capability.
Álvaro Martín‐Montes, Kristina Kolodová, Clotilde Marín, María José Rosales‐Lombardo, Manuel Sánchez‐Moreno, Lucía de Andrés‐Gordo, Carmen Cano, Lucrecia Campayo, Alberto Gómez‐Muñoz, Ana M. Sanz, María J. R. Yunta   +10 more
wiley   +1 more source

Pi‐Stacking Enhances Stability, Scalability of Formation, Control over Flexibility, and Circulation Time of Polymeric Filamentous Nanocarriers

Advanced NanoBiomed Research, Volume 1, Issue 11, November 2021., 2021
Coassembly of pi‐stacking perylene bisimide (PBI)‐containing tetrablock copolymers with diblock copolymers enhances the stability, scalable formation, and control over flexibility of polymeric filamentous nanocarriers. When compared with PBI‐free filaments, mixed PBI filaments with an optimal flexibility demonstrate reduced uptake by mouse macrophages ...
Sophia Li, Sharan Bobbala, Michael P. Vincent, Mallika Modak, Yugang Liu, Evan A. Scott   +5 more
wiley   +1 more source

Structure–Assembly–Property Relationships of Simple Ditopic Hydrogen-Bonding-Capable π-Conjugated Oligomers

Organic Materials, 2021
A series of simple ditopic hydrogen-bonding-capable molecules functionalized with 2,4-diamino-1,3,5-triazine (DAT), barbiturate (B), and phthalhydrazide (PH) on both termini of a 2,2′-bithiophene linker were designed and synthesized.
Asmerom O. Weldeab, Cory T. Kornman, Lei Li, Daken J. Starkenburg, Xueying Zhao, Danielle E. Fagnani, Sara J. Sadovy, Scott S. Perry, Jiangeng Xue, Ronald K. Castellano   +9 more
doaj   +1 more source

PhI(OAc)₂-Mediated Novel 1,3-Dipolar Cycloaddition of Methylenecyclopropanes (MCPs), Vinylidenecyclopropanes (VCPs), and Methylenecyclobutane (MCB) with Phthalhydrazide

, 2016
Iodobenzene diacetate-mediated reactions of methylenecyclopropanes 1, vinylidenecyclopropanes 2, and a methylenecyclobutane 3a with phthalhydrazide give the corresponding [3+2] cycloaddition products in good yields under mild conditions.
Min Shi (141075), Le-Ping Liu (2259280), Jian-Mei Lu (1632748)   +2 more
core   +2 more sources

Efficient ZrO(NO3)2.2H2O Catalyzed Synthesis of 1H‐Indazolo[1,2‐b] phthalazine‐1,6,11(13H)‐triones and Electronic Properties Analyses, Vibrational Frequencies, NMR Chemical Shift Analysis, MEP: A DFT Study

Heteroatom Chemistry, Volume 2020, Issue 1, 2020., 2020
The synthesis of 1H‐indazolo[1,2‐b]phthalazine‐1,6,11(13H)‐trione derivatives, using one‐pot three‐component condensation reaction of 3‐nitrophthalic anhydride, hydrazine monohydrate, dimedone, and aromatic aldehydes in the presence of ZrO(NO3)2.2H2O as the novel catalyst and in reflux conditions in EtOH was reported.
Forozan Piryaei, Nahid Shajari, Hooriye Yahyaei, Xing-Hai Liu   +3 more
wiley   +1 more source

Electrochemical and quantum chemical studies on phthalhydrazide as corrosion inhibitor for mild steel in 1 M HCl solution

, 2023
   Phthalhydrazide (PTD) was studied for its ability to inhibit mild steel corrosion in 1M HCl at 30°C using electrochemical measurements such as impedance spectroscopy (EIS) and potentiodynamic polarization techniques, as well as quantum chemical ...
Ramzi Jalgha, (16392108), Ahmed Musa (6602144)   +1 more
core   +1 more source

SnO2 nanoparticles as an efficient heterogeneous catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones

Journal of Nanostructure in Chemistry, 2017
A new protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives is described via a one-pot three-component condensation reaction of phthalhydrazide, dimedone or 1,3-cyclohexanedione and aromatic aldehydes catalyzed by SnO2 ...
Cinnathambi Subramani Maheswari, Chandrabose Shanmugapriya, Krishnan Revathy, Appaswami Lalitha   +3 more
doaj   +1 more source