Results 131 to 140 of about 5,609,700 (305)

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Associations of handgrip strength asymmetry with physical frailty, cognitive impairment, and cognitive frailty: A cross-sectional finding from the Longitudinal Ageing Study in India (LASI), Wave 1 (2017-18)

Clinical Epidemiology and Global Health
Objectives: As one ages, it becomes essential to anticipate and address the obstacles that impede the pursuit of healthy ageing. Thus, the present study aims to find out the associations between hand grip strength (HGS) asymmetry, physical frailty ...
Inderdeep Kaur, Nirmal Nath Upadhyay, Shivani Chandel   +2 more
doaj   +1 more source

Exercise interventions to improve physical frailty and physical frailty components in older adults with hypertension: A systematic review

Ageing Research Reviews
Physical frailty and hypertension are both highly prevalent among older adults. Furthermore, physical frailty may impact the risk-benefit ratio of pharmacological hypertension treatment. Thus, it may be prudent to focus on physical activity and exercise interventions to achieve better patient outcomes that addresses both conditions.
L, Vlietstra, A M, Fordyce, E C, Costa, S, Coffey, X J, Walker, G A, Whalley, D L, Waters   +6 more
openaire   +2 more sources

Postural instability and the condition of physical frailty in the elderly.

Revista latino-americana de enfermagem, 2019
Objective: to analyze the relationship between postural instability and the condition and markers of physical frailty of the elderly people in outpatient geriatric and gerontology care. Method: a cross-sectional study with a sample of 381 elderly subjects. Physical frailty was evaluated by the frailty phenotype and postural instability through the Berg
Moraes, Dayana Cristina, Lenardt, Maria Helena, Seima, Marcia Daniele, Mello, Bruno Henrique de, Setoguchi, Larissa Sayuri, Setlik, Clarice Maria   +5 more
openaire   +3 more sources

Physical frailty predicts adverse outcomes in hospitalized patients with acute decompensation of cirrhosis

reservedBACKGROUND AND AIM: Patients with end-stage liver disease are at high risk of malnutrition, sarcopenia and frailty. Recent evidence indicates that physical frailty, as assessed by liver frailty index (LFI), is an independent predictor of ...
D'ARCANGELO, FRANCESCA
core  

A shared frailty semi-parametric markov renewal model for travel and activity time-use pattern analysis [PDF]

This study investigates the influence of observed explanatory factors and unobserved random effect (heterogeneity) on episode durations of travel-activity chain.
Charles Raux, Iragaël Joly, Tai-Yu Ma
core  

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Feasibility of using information derived from a care partner to develop a frailty index based on comprehensive geriatric assessment

, 2013
Background: Frailty is a state of increasing vulnerability that places an individual at high risk for adverse health outcomes. The best approach for frailty measurement in clinical practice has not been resolved.

core   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source