Results 121 to 130 of about 5,609,700 (305)

Ageing in Mexico : modelling health and frailty and its relationship to the use of health services and the supply of informal care [PDF]

Mexico is still a "young" country with pressing burdens on education, especially at secondary and high school levels, and high percentages of the population entering the work force each year. Yet, it will complete its "demographic transition" in the
Lopez-Ortega, Mariana
core   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Evolution and interrelation of physical frailty and mild cognitive impairment up to two years after kidney transplantation: a multi-center prospective cohort study

Transplant International
Kidney transplantation (KT) is the preferred treatment for kidney failure, providing superior survival and quality of life compared with haemodialysis. However, the demand for transplantation exceeds organ availability, underscoring the need to optimize ...
Nadine Beerli, Nadine Beerli, Manuel Wehrle, Isabelle Binet, Michael Dickenmann, Déla Golshayan, Karine Hadaya, Uyen Huynh-Do, Reto W. Kressig, Sabina De Geest, Sabina De Geest, Oliver Mauthner, Oliver Mauthner   +12 more
doaj   +1 more source

Sleep and physical frailty in older adults

, 2021
Motivations The relationship between sleep and frailty in older age is complex. Two approaches were employed to advance our understanding of the association between insomnia and physical frailty in old age.
鄧綺汶, Tang, Yee-man
core  

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

A longitudinal study on multiple frailty and its associations with depression and social participation in older adults

Scientific Reports
To explore the changes in the physical, cognitive, and social frailty over a two-year follow-up and to identify the predictors associated with multiple frailty.
JuHee Lee, Jungah Park, Miji Kim, Sumi Lee, Chang Won Won   +4 more
doaj   +1 more source

Association between objective physical activity and frailty transition in community-dwelling prefrail Japanese older adults

The Journal of Nutrition, Health and Aging
Background: Frailty transition is common, and increased physical activity can prevent it. An objective assessment of physical activity could eliminate bias and provide more precise information on the association between frailty transitions and physical ...
Yu-Shan Lee, Yukiko Nishita, Chikako Tange, Shu Zhang, Hiroshi Shimokata, Shih-Yi Lin, Wei-Min Chu, Rei Otsuka   +7 more
doaj   +1 more source

Integrating Frailty and Physical Resilience to Improve Risk Estimation in Aging Populations

Background: Physical resilience, broadly defined as the ability to resist or recover from health stressors, is a relatively new concept in the field of aging, yet, anticipated as a potentially game-changing idea.
Smith, Nathan Kyle
core