Results 101 to 110 of about 5,609,700 (305)

Evaluating frailty scores across experimental groups in rodent models: bridging physical and cognitive domains

FEBS Open Bio
Frailty, a reversible clinical geriatric syndrome, impairs the ability to maintain homeostasis, leading to severe consequences such as hospitalization and death.
Aleksandra Mladenovic, Smilja Pracer
doaj   +1 more source

Association of Oral Frailty with Physical Frailty and Malnutrition in Patients on Peritoneal Dialysis

Nutrients
Background: Oral frailty is a state between normal oral function and oral hypofunction. Oral frailty progresses to oral hypofunction and dysphagia, which leads to malnutrition, and then to physical frailty and sarcopenia. Oral frailty is reported to be associated with physical frailty and malnutrition in hemodialysis patients, but there have been no ...
Yu Kobayashi, Tomomi Matsuoka, Ryo Yamaguchi, Kiyomi Ichijo, Miya Suzuki, Tomoyuki Saito, Kimihiro Igarashi, Tokiko Sato, Hiroyuki Takashima, Masanori Abe   +9 more
openaire   +2 more sources

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Investigating the role of frailty in the expression of dementia

, 2020
Background: Frailty is related to neuropathological features of Alzheimer’s disease (AD) as well as cognitive decline and dementia. Objectives: 1) determine whether frailty moderates the relationship between neuropathology and dementia status in ...
Wallace, Lindsay M K
core  

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Longitudinal dynamic relationships among social frailty, depression, cognitive function, and physical frailty in community-dwelling older adults: A random intercept cross-lagged panel model study

International Journal of Nursing Studies Advances
Background: Social frailty is a critical indicator of social health in older adults. While its links to physical and mental health are recognized, longitudinal evidence integrating social frailty, depressive symptoms, cognitive function, and physical ...
Anni Wu, Sheng Sun, Xiaoshuai Huang, Hui Yin, Yuxin Sun, Bolun Zhao   +5 more
doaj   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

The role of NLRP3 neuroinflammation in cognitive frailty diversity during aging and after LPS administration in mice

Scientific Reports
Aging leads to declines in physical and cognitive functions, with NLRP3-associated neuroinflammation playing a key role. While physical frailty quantifies age-related physiological decline, the concept of cognitive frailty, integrating physical frailty ...
Yulia Komleva, Alexandra Lukyanchuk, Anna Blagova, Ilia Potapenko, Maria Kukla, Victoria Zhdankina, Elizaveta Perepelitsa, Natalia Kolotyeva, Irina Berdalina, Kristina Nazarova, Alla Salmina, Sergey Illarioshkin   +11 more
doaj   +1 more source

Frailty Phenotype Prevalence in Community-Dwelling Older Adults According to Physical Activity Assessment Method

Clinical Interventions in Aging, 2020
Carina Ziller,1 Tobias Braun,1 Christian Thiel1,2 1Department of Applied Health Sciences, Division of Physiotherapy, Hochschule für Gesundheit (University of Applied Sciences), Bochum, Germany; 2Faculty of Sports Science, Training and Exercise ...
Ziller C, Braun T, Thiel C
doaj  

The Effect of Young People–Assisted, Individualized, Motion-Based Video Games on Physical, Cognitive, and Social Frailty Among Community-Dwelling Older Adults With Frailty: Randomized Controlled Trial [PDF]

BackgroundThe aging population highlights the need to maintain both physical and psychological well-being. Frailty, a multidimensional syndrome, increases vulnerability to adverse outcomes.
Chow, Karen Kit Sum, Siu Man Wong, Liu, Bob Chung Man, Kowatsch, Tobias; id_orcid, David Chi Ho Lau, Jonathan Bayuo, Zhang, Melissa Qian, Bob Chung Man Liu, Wong, Siu Man, Wong, Arkers Kwan Ching, Wong, Bonnie Po, Kowatsch, Tobias, Tobias Kowatsch, Arkers Kwan Ching Wong, Melissa Qian Zhang, Lau, David Chi Ho, Bayuo, Jonathan, Karen Kit Sum Chow, Bonnie Po Wong   +18 more
core   +1 more source