Results 81 to 90 of about 5,609,700 (305)

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? : a systematic review

, 2021
Background: Frailty is strongly associated with adverse cardiovascular outcomes; however, the underlying pathophysiological processes are largely unknown.
Schwarz, Peter, Chang, Dennis Hsu-Tung (R7407), Tan, Timothy C. (R18444), Chang, Dennis, Amarasekera, Anjalee T. (R19063), Amarasekera, Anjalee Thanuja, Tan, Timothy C   +6 more
core   +1 more source

Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries

Advanced Materials, EarlyView.
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi, Bo Jiang, Jingcheng Zhang, Xiaodong Shao, Peixun Xiong, Lutong Shan, Shengyang Huang, Mengfang Liang, Mengyao Chang, Fangyan Liu, Wenwu Li, Baoyu Xia, Wei Ji, Ho Seok Park   +13 more
wiley   +1 more source

The Role of Physical Activity and Physical Function in Predicting Physical Frailty Transitions in Chinese Older Adults: Longitudinal Observational Study From CHARLS

JMIR Aging
BackgroundFrailty is a dynamic geriatric syndrome associated with adverse health outcomes, yet its progression can be mitigated through targeted interventions.
Ziwei Zeng, Chun Liang Hsu, Cindy Hui-ping Sit, Stephen Heung-sang Wong, Yijian Yang   +4 more
doaj   +1 more source

Frailty in survival analysis models (parametric frailty, parametric shared frailty, and frailty in Cox models [PDF]

Frailty models are used to model survival times in the presence of overdispersion or group-specific random effects. The latter are distinguished from the former by the term "shared" frailty models.
Roberto G. Gutierrez
core  

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Goodness-of-fit tests for the frailty distribution in proportional hazards models with shared frailty. [PDF]

Frailty models account for the clustering present in grouped event time data. A proportional hazards model with shared frailties expresses the hazard for each subject. Often a one-parameter gamma distribution is assumed for the frailties. The choice of a
Claeskens, Gerda, Janssen, Paul, Geerdens, Candida   +2 more
core  

Frailty-associated factors among Brazilian community-dwelling elderly people: longitudinal study

, 2019
BACKGROUND: Frailty among elderly people is associated with negative health outcomes. Through gaining better understanding of this syndrome over different time periods, healthcare actions that take predictive factors into consideration may be ...
Maycon Sousa Pegorari (4701337), Darlene Mara dos Santos Tavares (4701325)   +1 more
core   +1 more source

Efficient Sunlight Degradation of Wide‐Spectrum Antibiotics Through Enhanced Charge Separation in SnTCPP NPs‐Nb2C Schottky Heterojunction: Ultrafast Carrier Dynamic Study

Advanced Materials Interfaces, EarlyView.
Due to enhanced charge transfer and carrier mobility on the surface, the SnTCPP NPs‐Nb2C Schottky heterojunctions demonstrate exceptional sunlight‐driven catalytic activity toward tetracycline antibiotics and ofloxacin degradation, achieving a removal efficiency of up to 99.9% within 60 min of irradiation, both in model wastewater and natural water ...
Juanxuan Guo, Sheng Liao, Ranye Liao, Xinyan Ke, Ming‐De Li, Li Dang   +5 more
wiley   +1 more source

Prevalence of Physical and Oral Frailty Among the Community-Dwelling Geriatric Population of Thrissur, Kerala

Journal of the Indian Academy of Geriatrics
Objective: Data on the prevalence of frailty in Kerala are sparse. The objective of this study was to estimate the prevalence of frailty among community-dwelling older people in Kerala and explore the sociodemographic factors associated with physical and
K. N. Sandhya, Beena Varma, Chandrashekar Janakiram, Priya Vijayakumar, Niveditha Kartha   +4 more
doaj   +1 more source