Results 111 to 120 of about 3,167,735 (339)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Statistical Power Supply Dynamic Noise Prediction in Hierarchical Power Grid and Package Networks [PDF]

, 2008
One of the most crucial high performance systems-on-chip design challenge is to front their power supply noise sufferance due to high frequencies, huge number of functional blocks and technology scaling down.
Casu, Chen, Deutsch, G. Piccinini, Hashemi, Kozhaya, Lee, M. Graziano, Mezhiba, Zhao, Zheng   +10 more
core   +1 more source

Comparison of Standard Clinical and Instrumented Physical Performance Tests in Discriminating Functional Status of High-Functioning People Aged 61–70 Years Old

Italian National Conference on Sensors, 2019
Assessment of physical performance by standard clinical tests such as the 30-s Chair Stand (30CST) and the Timed Up and Go (TUG) may allow early detection of functional decline, even in high-functioning populations, and facilitate preventive ...
A. Coni, J. M. V. Ancum, Ronny Bergquist, A. S. Mikolaizak, S. Mellone, L. Chiari, A. Maier, M. Pijnappels   +7 more
semanticscholar   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The Coherence Problem: Mapping the Theory and Delivery of Infrastructure Resilience Across Concept, Form, Function, and Experienced Value [PDF]

, 2015
In this contribution we explore the interface between the functional characteristics of infrastructures as artefacts and social need supplier. Specifically we are concerned with the ways in which infrastructure performance measures are articulated and ...
Jeffrey, P., Smith, H.
core  

protocol and rationale of a randomized clinical trial (AMINO-Stroke Study) [PDF]

, 2016
Background Patients with stroke are at a high risk for long-term handicap and disability. In the first weeks after stroke muscle wasting is observed frequently. Early post-stroke rehabilitation programs are directed to improve functional independence and
Anker, Stefan D., Dirnagl, Ulrich, Doehner, Wolfram, Ebner, Nicole, Haehling, Stephan von, Haeusler, Karl Georg, Joebges, Michael, Meisel, Andreas, Sandek, Anja, Scherbakov, Nadja   +9 more
core   +1 more source

THE ASSOCIATION BETWEEN THE FUNCTIONAL MOVEMENT SCREENTM, Y-BALANCE TEST, AND PHYSICAL PERFORMANCE TESTS IN MALE AND FEMALE HIGH SCHOOL ATHLETES.

International Journal of Sports Physical Therapy, 2019
Background Poor balance, lack of neuromuscular control, and movement ability are predictors of performance and injury risk in sports and physical activity participation.
Taylor A Kramer, R. Sacko, C. Pfeifer, D. Gatens, Justin M. Goins, D. Stodden   +5 more
semanticscholar   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Pulmonary rehabilitation : insight into current trends [PDF]

, 2010
Pulmonary rehabilitation is a widely accepted therapeutic tool used to improve the quality of life and functional capacity of individuals with chronic lung disease.
Montefort, Stephen, Sciriha, Anabel
core