Results 121 to 130 of about 3,167,735 (339)

Declines in swimming performance with age: a longitudinal study of Masters swimming champions. [PDF]

, 2013
IntroductionBecause of its many participants and thorough records, competitive Masters swimming offers a rich data source for determining the rate of physical decline associated with aging in physically fit individuals.
Auerbach, Daniel, Curtis, Amy, Lin, Sonia, Rubin, Robert T, Win, Charlene   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Patient-oriented and performance-based outcomes after knee autologous chondrocyte implantation: a timeline for the first year of recovery [PDF]

, 2014
It is well established that autologous chondrocyte implantation (ACI) can require extended recovery postoperatively; however, little information exists to provide clinicians and patients with a timeline for anticipated function during the first year ...
English, R. A., Howard, J. S., Lattermann, C., Mattacola, C. G., Mullineaux, David   +4 more
core   +1 more source

Testosterone Plus Low-Intensity Physical Training in Late Life Improves Functional Performance, Skeletal Muscle Mitochondrial Biogenesis, and Mitochondrial Quality Control in Male Mice

PLoS ONE, 2012
Testosterone supplementation increases muscle mass in older men but has not been shown to consistently improve physical function and activity. It has been hypothesized that physical exercise is required to induce the adaptations necessary for translation
Wen Guo, S. Wong, Michelle Li, Wentao Liang, M. Liesa, Carlo Serra, Ravi Jasuja, A. Bartke, J. Kirkland, O. Shirihai, S. Bhasin   +10 more
semanticscholar   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Acute Effects of Velocity-Based Resistance Training on the Physical Functional Performance of Older Adults. [PDF]

Int J Exerc Sci, 2022
Pinto SS, Bezerra ES, Silva KG, Ramirez-Campillo R, Ben Abderrahman A.   +4 more
europepmc   +1 more source

AGE PECULIARITIES OF KNEE FUNCTIONALITY AND PHYSICAL PERFORMANCE IN ELDERLY WOMEN

Human Sport Medicine, 2020
Aim. The aim of this study is to learn the effect of the age on degenerative knee joint disease and physical capability of elderly women. Materials and methods. Three groups of relatively healthy elderly women (G1 – 60–64 years (n = 34), G2 – 65–69 years (n = 31) and G3 – 70–74 years (n = 18)) participated in the study.
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Role of physical and motor performance in predicting functional movement capacity in youth female volleyball players

Human Movement
Purpose This study aims to determine the extent to which physical and motor performance can predict functional movement capacity, an important indicator of mobility and injury risk in young volleyball players.
Umut Canli, Aydın Karaçam, Bekir Erhan Orhan, Zeynep Doğan, Ali Mert Şendil, Selim Esgiyayla, Barış Öngören, Pablo Prieto-González   +7 more
doaj   +1 more source

Assessing lower extremity loading during activities of daily living using continuous-scale physical functional performance 10 and wireless sensor insoles: a comparative study between younger and older adults. [PDF]

Eur J Trauma Emerg Surg, 2023
Häckel S, Kämpf T, Baur H, von Aesch A, Kressig RW, Stuck AE, Bastian JD.   +6 more
europepmc   +1 more source