Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Unstable Layers in the Mesopause Region Observed with Na Lidar During the Turbulent Oxygen Mixing Experiment (TOMEX) Campaign [PDF]
, 2004 The Na wind/temperature lidar located at Starfire Optical Range near Albuquerque, New Mexico, provided real time measurements of wind, temperature, and Na density in the mesopause region during the TOMEX rocket campaign in October 2000.
Liu, Alan Z. +4 more
core +2 more sources
Detection of Diffuse Interstellar [O II] Emission from the Milky Way Using Spatial Heterodyne Spectroscopy [PDF]
, 2006 Using a newly developed spatial heterodyne spectrometer (SHS), we have obtained the first radial velocity resolved emission-line profiles of diffuse [O II] 3726 and 3729 angstrom emission lines from the warm (10,000 K) ionized component of our Galaxy ...
Harlander, J. M. +4 more
core +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Maui Mesosphere and Lower Thermosphere (Maui MALT) Observations of the Evolution of Kelvin-Helmholtz Billows Formed Near 86 km Altitude [PDF]
, 2005 Small-scale (less than 15 km horizontal wavelength) structures known as ripples have been seen in OH airglow images for nearly 30 years. The structures have been attributed to either convective or dynamical instabilities; the latter are mainly due to ...
Hecht, J. H. +3 more
core +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Measurements of Mesospheric Sodium Abundance above the Hawaiian Islands [PDF]
, 2007 Laser guide stars have increased the utility of adaptive optics systems by expanding the number of observable objects. The most common type of laser excites sodium in the mesosphere, and mesospheric sodium density is key to the performance of the laser ...
Bradford, L. William +3 more
core +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
On The Theoretical Problematic of Arabic Physical Science Or Why Did Arabic Science Fail To Achieve The Copernican Revolution? [PDF]
arXiv, 2012 A Hegelian version of the concept of problematic is used to investigate the underlying theoretical unity and structure of Arabic physical science (physics, astronomy and chemistry). A contradictory triad (associated with Platonism, Aristotelian philosophy and Ptolemaic science) is identified at the heart of the Arabic project for physical science.
arxiv
The Impact of Physical Activity and Sport on Mental Health
التربية الرياضية, 2020 Scientists have researched different aspects of physical exercise and sports and their impact on the health of a person. However, the impact of physical activity and sport on mental health has not been looked into extensively.
Tamadher abdluaziz Muhsen +1 more
doaj +1 more source