Results 201 to 210 of about 800,730 (253)

Physical and chemical stability of drug nanoparticles

Advanced Drug Delivery Reviews, 2011
As nano-sizing is becoming a more common approach for pharmaceutical product development, researchers are taking advantage of the unique inherent properties of nanoparticles for a wide variety of applications. This article reviews the physical and chemical stability of drug nanoparticles, including their mechanisms and corresponding characterization ...
Libo Wu
exaly   +3 more sources

Physical stability of insulin formulations

Diabetes, 1983
Insulin aggregation remains a fundamental obstacle to the long-term application of many insulin infusion systems. We here report the effects of physiologic and nonphysiologic compounds on the aggregation behavior of crystalline zinc insulin (CZI) solutions.
W D, Lougheed, A M, Albisser, H M, Martindale, J C, Chow, J R, Clement   +4 more
openaire   +2 more sources

Chemical stability of liposomes: implications for their physical stability

Chemistry and Physics of Lipids, 1993
In the first part of this article, chemical and physical stability of aqueous liposome dispersions have been addressed. Chemical stability of phospholipids has been considered in two parts: oxidation and hydrolysis. Major attention has been paid to hydrolysis kinetics of phospholipids as a function of pH, temperature, buffer concentration and ionic ...
M, Grit, D J, Crommelin
openaire   +2 more sources

The physics of sawtooth stabilization

Plasma Physics and Controlled Fusion, 2007
Long period sawteeth have been observed to result in low-beta triggering of neo-classical tearing modes, which can significantly degrade plasma confinement. Consequently, a detailed physical understanding of sawtooth behaviour is critical, especially for ITER where fusion-born a particles are likely to lead to very long sawtooth periods.
Chapman, I. T., Pinches, S. D., Graves, J. P., Akers, R. J., Appel, L. C., Budny, R. V., Coda, S., Conway, N. J., de Bock, M., Eriksson, L.-G., Hastie, R. J., Hender, T. C., Huysmans, G. T. A., Johnson, T., Koslowski, H. R., Kraemer-Flecken, A., Lennholm, M., Liang, Y., Saarelma, S., Sharapov, S. E., Voitsekhovitch, I.   +20 more
openaire   +3 more sources

On whitespace and stability in physical synthesis

Integration, 2006
Abstract In the context of physical synthesis, large-scale standard-cell placement algorithms must facilitate incremental changes to layout, both local and global. In particular, flexible gate sizing, net buffering and detail placement require a certain amount of unused space in every region of the die.
Saurabh N. Adya, Igor L. Markov, Paul G. Villarrubia   +2 more
openaire   +1 more source

Physical Stability of Sulfaguanidine Suspensions

Journal of Pharmaceutical Sciences, 1970
Abstract The effects of several variables—electrolyte, type, and concentration of surfactant and nature of vehicle—upon the physical properties of sulfaguanidine suspensions have been investigated. It is shown that the concept of controlled flocculation may usefully be applied to the formulation of pharmaceutically acceptable suspensions of this drug.
R D, Jones, B A, Matthews, C T, Rhodes
openaire   +2 more sources

Physical stability of chocolate milk

International Journal of Food Science & Technology, 1987
SummaryThe stability of chocolate milk, made from two different cocoa powders and skim milk, was studied. Three types of instability could be distinguished: sedimentation of cocoa particles, formation of large flocs and formation of light and dark coloured layers (segregation).
van den Boomgaard, Th., van Vliet, T., van Hooydonk, A.C.M.   +2 more
openaire   +1 more source

Physical Stabilization of Insulin by Glycosylation

Journal of Pharmaceutical Sciences, 1995
The modification of human insulin by the covalent attachment of monosaccharide moieties to insulin amino group(s) alters the aggregation and self-association behavior, improving both the pharmaceutical stability and biological response. The synthesis of p-succinamidophenyl glucopyranoside-insulin conjugate(s) (SAPG-insulin) has resulted in seven ...
M, Baudys, T, Uchio, D, Mix, D, Wilson, S W, Kim   +4 more
openaire   +2 more sources

Physical Stability Testing of Pharmaceuticals

Journal of Pharmaceutical Sciences, 1964
The importance of physical stability of pharmaceuticals and methods of testing physical stability of tablets, capsules, suspensions, emulsions, solutions, and ointments are discussed.
openaire   +2 more sources

Chemical and Physical Stability of Microbially Stabilized Aggregates

Soil Science Society of America Journal, 1971
Abstract Chemical properties of microbially bound aggregates were determined by organic solvent extraction and by the rate of sonic dispersion of the aggregates. Seven fungi, six streptomycetes, and four bacteria, produced in situ chemically different binding agents which ...
R. B. Aspiras, O. N. Allen, G. Chesters, R. F. Harris   +3 more
openaire   +1 more source