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Physical stabilization of DNA-based therapeutics
Drug Discovery Today, 2001The development of non-viral vectors for gene delivery has primarily focused on improving the efficiency of gene transfer in vivo. Although there is clearly a need to improve delivery efficiency, studies also indicate that the physical stability of non-viral vectors is not nearly adequate for a marketable pharmaceutical product.
T J., Anchordoquy +4 more
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Physical and chemical stability of drug nanoparticles
Advanced Drug Delivery Reviews, 2011As nano-sizing is becoming a more common approach for pharmaceutical product development, researchers are taking advantage of the unique inherent properties of nanoparticles for a wide variety of applications. This article reviews the physical and chemical stability of drug nanoparticles, including their mechanisms and corresponding characterization ...
Libo, Wu, Jian, Zhang, Wiwik, Watanabe
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Determinism and Stability in Physics
2018This chapter examines the role of stability and determinism in physical theories such as statistical mechanics. In the physical sciences, the notions of stability and instability, no longer camouflaged in the language of necessity and contingency, are often used in a variety of contexts, from chaos theory to quantum mechanics.
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Stabilizing Integrators for Real-Time Physics
ACM Transactions on Graphics, 2018We present a new time integration method featuring excellent stability and energy conservation properties, making it particularly suitable for real-time physics. The commonly used backward Euler method is stable but introduces artificial damping. Methods such as implicit midpoint do not suffer from artificial damping but are unstable in many common ...
Dimitar Dinev +2 more
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Characterisation and physical stability of PEGylated glucagon
International Journal of Pharmaceutics, 2007Glucagon was mono-PEGylated with PEG 5000 at Lys-12 to examine the effect on conformation and physical stability during purification and freeze-drying. The model peptide glucagon is highly unstable and readily forms fibrils in solution. Secondary structure was determined by FTIR and far-UV CD and physical stability was assessed by the Thioflavin T ...
Stigsnæs, Pernille +5 more
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Evaluation of the physical stability of two oleogels
International Journal of Pharmaceutics, 2006Oleogels are semisolid systems obtained with an organogelator and a hydrophobic liquid that have been investigated over the past few years and that could play an important role as dermatological bases. Recently, we have developed an oleogel of sorbitan monostearate (19wt.%) and sweet almond oil (SM-SAO) and another one of cholesterol (3.5wt.%) and ...
Isabel F, Almeida, M Fernanda, Bahia
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Stability of Physical Activity across the Lifespan
Journal of Health Psychology, 2008Physical activity is associated with various health-relevant psychosocial and physiological processes, but activity stability across extended time periods is inadequately understood. This lifespan longitudinal cohort study examined activity levels of 723 males and 554 females.
Howard S, Friedman +5 more
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the Physical Stability of Natrolite.
1956Experiments have been made to determine the stability field of natrolite under elevated pressures and temperatures. The validity of the experiments as reproductions of nature's processes is examined. The equilibrium curve for the upper limit of the natrolite stability field was determined for certain fixed environmental conditions.
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Physical-chemical limits for the stability of biomolecules
Advances in Space Research, 1986Water is an indispensable prerequisite for the existence of life. Only in an aqueous environment can biomolecules take up their native, tertiary structure and organize themselves into higher aggregates like multienzyme complexes or cell-organelles. In most of these processes interactions between biomolecules and water play an important role.
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Stability of Physical Performance Test Scores
Research Quarterly. American Association for Health, Physical Education and Recreation, 1969Abstract On each of three days 73 subjects were administered three trials of a standing broad jump test, and 48 subjects were administered five trials of a side-step test. A significant trial-to-trial variability within days was found for the side-step test.
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