Results 61 to 70 of about 982,684 (307)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Tele-rehabilitation using transcranial direct current stimulation combined with exercise in people with spinal cord injury: a randomized controlled trial

Journal of Rehabilitation Medicine
Objective: This study explored the effects of home-based transcranial direct current stimulation combined with exercise on motor and sensory function, spasticity, functional and transfer performance, and quality of life.
Thanwarat Chantanachai, Irin Apiworajirawit, Pipat Klamruen, Benchaporn Aneksan, Paradee Auvichayapat, Alexandra Lackmy-Vallée, Wanalee Klomjai   +6 more
doaj   +1 more source

Sensory Electrical Stimulation Improves Foot Placement during Targeted Stepping Post-Stroke [PDF]

, 2014
Proper foot placement is vital for maintaining balance during walking, requiring the integration of multiple sensory signals with motor commands. Disruption of brain structures post-stroke likely alters the processing of sensory information by motor ...
A Kaelin-Lang, AA Priplata, AL Hof, AL Hof, Allison S. Hyngstrom, AR Fugl-Meyer, Brian D. Schmit, CK Balasubramanian, CM Said, CW Wu, DC Kerrigan, DM Corbin, DS Marigold, DS Reisman, Eric R. Walker, F Bretzner, GI Turnbull, IN Beloozerova, JH Nonnekes, JS Sulzer, KM Michael, KO Berg, MD Lewek, MG Bowden, MO Conrad, MO Conrad, MS Alexander, ND Neckel, P Novak, RB Davis, S Hesse, S Mudge, SF Tyson, SFH Mackintosh, SM O’Connor, TH Cruz   +35 more
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The effect of sensory stimulation on quality of life of the elderly and their self-efficacy for coping with the fear of falling

Iranian Journal of Nursing and Midwifery Research, 2020
Background: Aging causes major changes that affect the performance of all senses, and as a result, a critical change in the quality of life is expected.
Alehe Seyyedrasooli, Morteza Ghojazadehm, Sakineh Goljaryan, Mohammad-Salar Hosseini, Mahdieh Esmaeilnezhad   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Home-based Functional Electrical Stimulation for long-term denervated human muscle: History, basics, results and perspectives of the Vienna Rehabilitation Strategy

European Journal of Translational Myology, 2014
We will here discuss the following points related to Home-based Functional Electrical Stimulation (h-b FES) as treatment for patients with permanently denervated muscles in their legs: 1.
Helmut Kern, Ugo Carraro
doaj   +3 more sources

Head phantoms for electroencephalography and transcranial electric stimulation: a skull material study

, 2018
Physical head phantoms allow assessing source reconstruction procedures in electroencephalography and electrical stimulation profiles during transcranial electric stimulation. Volume conduction in the head is strongly influenced by the skull representing
Fiedler, Patrique, Haueisen, Jens, Hunold, Alexander, Strohmeier, Daniel   +3 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction [PDF]

, 2017
Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic
Budiono, Boris P, Headrick, John P., Neumann, David L., Peart, Jason N., Shum, David H K, Stapelberg, Nicolas J C   +5 more
core   +1 more source