Predicting Pharmacokinetics of Drugs Using Physiologically Based Modeling—Application to Food Effects [PDF]
The AAPS Journal, 2009 Our knowledge of the major mechanisms underlying the effect of food on drug absorption allows reliable qualitative prediction based on biopharmaceutical properties, which can be assessed during the pre-clinical phase of drug discovery. Furthermore, several recent examples have shown that physiologically based absorption models incorporating biorelevant
N, Parrott +3 more
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Neurochemical and Physiological Effects of Cocaine Oscillate with Sequential Drug Treatment: Possibly a Major Factor in Drug Variability [PDF]
Neuropsychopharmacology, 1995 Variability in response to drug treatment is a poorly understood problem with severe consequences for both the individual and the health care delivery system. Our data suggest that one source of variability may be inherent in the way physiological systems normally respond to repeated drug exposures.
S M, Antelman +5 more
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Effects of novel antidepressant drugs on mesenchymal stem cell physiology
Biomedicine & Pharmacotherapy, 2019 It is known that users of psychotropic drugs often have weight gain, adverse effects on bone mineral density and osteoporosis, but the molecular basis for these side effects is poorly understood. The aim of this study is to evaluate the effects in vitro of duloxetine (a serotonin and norepinephrine reuptake inhibitor) and fluoxetine (a selective ...
Ferroni, Letizia +5 more
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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes [PDF]
Frontiers in Pharmacology, 2019 Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes.
Alexandre J. S. Ribeiro +14 more
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Predicting the physiological effects of multiple drugs using electronic health record
Computers in Biology and MedicineABSTRACTVarious computational models have been developed to understand the physiological effects of drug-drug interactions, which can contribute to more effective drug treatments. However, they mostly focus on interactions of only two drugs, and do not consider the patient information.
Junhyeok Jeon +4 more
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Physiological effects of fentanyl analogs found in recreational drug markets [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2023 Charles W. Schindler +7 more
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Advanced Biomedical Research, 2022 Background: Due to the contradictory results of the effects of Vitamin B6 in reducing the hematotoxic effects of linezolid, the present study aimed to investigate the possible role of Vitamin B6 administration in reducing linezolid-related hematological ...
Kiana Shirani +5 more
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Anesthetic, Physiologic and Hematologic Effects of Three Pentobarbitone Drug Combinations in Rabbits [PDF]
Journal of Pharmacology and Toxicology, 2012 R.I. Udegbunam +2 more
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Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models
Veterinary Sciences, 2023 Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs,
Maria M. Kotova +9 more
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Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors. [PDF]
PLoS ONE, 2014 A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for
Caio Maximino +10 more
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