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Modelling the behaviour of physiological processes: On the lack of a scientific basis in medical science [PDF]
Communicative & Integrative BiologyPhysiological regulation is extremely complex and cannot be described by homeostasis, the mathematical model generally used in medical science. Homeostasis is based on assumptions which have never been tested or substantiated and when simulated appears ...
Abraham Peper
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Advanced Biomedical Research, 2022 Background: Due to the contradictory results of the effects of Vitamin B6 in reducing the hematotoxic effects of linezolid, the present study aimed to investigate the possible role of Vitamin B6 administration in reducing linezolid-related hematological ...
Kiana Shirani +5 more
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Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models
Veterinary Sciences, 2023 Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs,
Maria M. Kotova +9 more
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Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors. [PDF]
PLoS ONE, 2014 A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for
Caio Maximino +10 more
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Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms
Frontiers in Endocrinology, 2023 Long-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth ...
Junying Hua +7 more
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Side Effects of Human Drug Use: An Overview of the Consequences of Eels’ Exposure to Cocaine
Fishes, 2023 The widespread use of drugs is a global problem which affects not only humans but also the environment around them, as research is showing the presence of these substances in different environmental matrices, like air, water, and soil.
Luigi Rosati +5 more
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Peptides: Prospects for Use in the Treatment of COVID-19
Molecules, 2020 There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in ...
Vladimir Khavinson +4 more
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Arquivos Brasileiros de Cardiologia, 2010 Os anti-inflamatórios não esteroides (AINEs) encontram-se entre os medicamentos mais prescritos em todo o mundo. Essa classe heterogênea de fármacos inclui a aspirina e vários outros agentes inibidores da ciclo-oxigenase (COX), seletivos ou não. Os AINEs
Michel Batlouni
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The effects of estrogen on targeted cancer therapy drugs
Pharmacological Research, 2022 Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex hormone that not only promotes the development of female secondary sexual characteristics, but also supports many important physiological functions.
Ying Zhao +4 more
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Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney
Bioactive Materials, 2023 Currently, there are no clinical drugs available to treat acute kidney injury (AKI). Given the high prevalence and high mortality rate of AKI, the development of drugs to effectively treat AKI is a huge unmet medical need and a research hotspot. Although
Qiaohui Chen +11 more
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