Results 41 to 50 of about 492,192 (286)

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

iScience
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr   +10 more
doaj   +1 more source

Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate

Frontiers in Neurology, 2017
Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery.
Jan Kudlacek, Jan Kudlacek, Jan Chvojka, Jan Chvojka, Antonin Posusta, Lubica Kovacova, Seung Bong Hong, Seung Bong Hong, Shennan Weiss, Kamila Volna, Petr Marusic, Jakub Otahal, Premysl Jiruska   +12 more
doaj   +1 more source

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

Biomolecules, 2020
Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early ...
Ewelina Zaorska, Lenka Tomasova, Dominik Koszelewski, Ryszard Ostaszewski, Marcin Ufnal   +4 more
doaj   +1 more source

Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood

Medicina, 2023
Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs
Allison B. Reiss, Shelly Gulkarov, Aaron Pinkhasov, Katie M. Sheehan, Ankita Srivastava, Joshua De Leon, Aaron E. Katz   +6 more
doaj   +1 more source

Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism

European Journal of Epidemiology, 2014
The mechanism of antihypertensive and lipid-lowering drugs on the human organism is still not fully understood. New insights on the drugs’ action can be provided by a metabolomics-driven approach, which offers a detailed view of the physiological state ...
E. Altmaier, G. Fobo, M. Heier, B. Thorand, C. Meisinger, W. Römisch-Margl, M. Waldenberger, C. Gieger, T. Illig, J. Adamski, K. Suhre, G. Kastenmüller   +11 more
semanticscholar   +1 more source

Opioid Analgesia and Opioid-Induced Adverse Effects: A Review

Pharmaceuticals, 2021
Opioids are widely used as therapeutic agents against moderate to severe acute and chronic pain. Still, these classes of analgesic drugs have many potential limitations as they induce analgesic tolerance, addiction and numerous behavioural adverse ...
A. Paul, Craig M. Smith, M. Rahmatullah, V. Nissapatorn, P. Wilairatana, M. Spetea, N. Gueven, N. Dietis   +7 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

Frontiers in Endocrinology, 2022
Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide.
Safaet Alam, Md. Moklesur Rahman Sarker, Md. Moklesur Rahman Sarker, Taposhi Nahid Sultana, Md. Nafees Rahman Chowdhury, Mohammad A. Rashid, Nusrat Islam Chaity, Chao Zhao, Jianbo Xiao, Elsayed E. Hafez, Shah Alam Khan, Isa Naina Mohamed   +11 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Targeting drugs to APJ receptor: From signaling to pathophysiological effects

Journal of Cellular Physiology, 2018
G‐protein‐coupled receptors (GPCRs) are recognized as the largest protein receptor superfamily, which are widely distributed in various tissues and organs.
Zhen Huang, Lu He, Zhe Chen, Linxi Chen
semanticscholar   +1 more source