Results 71 to 80 of about 8,886,497 (252)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An intrinsic algorithm for computing geodesic distance fields on triangle meshes with holes

, 2012
Singapore National Research Foundation Interactive Digital Media RD Program [NRF2008IDM-IDM004-006]; NSFC [61100105, 61100107]; Natural Science Foundation of Fujian Province of China [2011J05007]As a fundamental concept, geodesics play an important role ...
He, Ying, Quynh, Dao T. P., Quynh, Dao Thi Phuong, Chen, Zhonggui, Xin, Shi-Qing, 陈中贵   +5 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Collision Risk Perception Models Using Physiological and Eye-Tracking Signals

IEEE Access
Accurate risk perception is essential for safe driving, particularly in dynamic and high-risk traffic environments. This study develops machine learning (ML)-based user risk perception models using physiological recording systems to assess driving risks ...
Hyowon Lee, Ocktaeck Lim, Amandeep Singh, Siby Samuel   +3 more
doaj   +1 more source

Homologous Basal Ganglia Network Models in Physiological and Parkinsonian Conditions

Frontiers in Computational Neuroscience, 2017
The classical model of basal ganglia has been refined in recent years with discoveries of subpopulations within a nucleus and previously unknown projections. One such discovery is the presence of subpopulations of arkypallidal and prototypical neurons in
Jyotika Bahuguna, Tom Tetzlaff, Arvind Kumar, Arvind Kumar, Jeanette Hellgren Kotaleski, Abigail Morrison, Abigail Morrison, Abigail Morrison   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Towards distributed real-time physiological processing in mobile environments [PDF]

, 2012
Physiological monitoring is the practice of using sensors to read, store, process and interpret physiological data from organic beings, including biofeedback signals associated with heart, brain, muscle and other organ activity.
Meneghello, James
core  

Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome

Molecular Systems Biology, 2020
Comprehensive molecular‐level models of human metabolism have been generated on a cellular level. However, models of whole‐body metabolism have not been established as they require new methodological approaches to integrate molecular and physiological ...
Ines Thiele, Swagatika Sahoo, Almut Heinken, Johannes Hertel, Laurent Heirendt, Maike K Aurich, Ronan MT Fleming   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The methylome of buccal epithelial cells is influenced by age, sex, and physiological properties

, 2023
Epigenetic modifications, particularly DNA methylation, have emerged as regulators of gene expression and are implicated in various biological processes and disease states.
Civlan, Serkan, Türkcüer, İbrahim, Sabirli, Ramazan, Sabırlı, Ramazan, Gören, Tarık, Rubbi, Liudmilla, Kurt, Ozgur, Protti, Giulia, Cıvlan, Serkan, Goren, Tarik   +9 more
core   +1 more source