Results 61 to 70 of about 7,637,456 (312)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Towards distributed real-time physiological processing in mobile environments [PDF]

, 2012
Physiological monitoring is the practice of using sensors to read, store, process and interpret physiological data from organic beings, including biofeedback signals associated with heart, brain, muscle and other organ activity.
Meneghello, James
core  

Unveiling nuances in data analysis to illuminate marine pilot strain

Frontiers in Psychology
Maritime studies, encompassing a range of disciplines, increasingly rely on advanced data analytics, particularly in the context of navigation. As technology advances, the statistical averaging of large datasets has become a critical component of these ...
Andrej Košir, Matija Svetina, Marko Perkovič, Franc Dimc, Tanja Brcko, Dejan Žagar   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Characterising the frequency response of impedance changes during evoked physiological activity in the rat brain [PDF]

, 2018
Electrical Impedance Tomography (EIT) can image impedance changes associated with evoked physiological activity in the cerebral cortex using an array of epicortical electrodes.
Faulkner, M, Hannan, S, Sana Hannan, James Avery, Mayo Faulkner, Hannan, Sana, Faulkner, Mayo, Aristovich, Kirill, Avery, James, David Holder, Holder, DS, Kirill Aristovich, Aristovich, KY, Avery, J, Holder, David   +14 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A carboxylesterase, Esterase-6, modulates sensory physiological and behavioural response dynamics to pheromone in Drosophila [PDF]

, 2012
Background: Insects respond to the spatial and temporal dynamics of a pheromone plume, which implies not only a strong response to"odor on", but also to"odor off". This requires mechanisms geared toward a fast signal termination.
Rosell Pellisé, Glòria, Chertemps, Thomas, Rosell, Gloria, Dekker Teun, Durand, Nicolas, Philippe Lucas, Maibeche Coisne, Martine, Nicolas Durand, Nicolas Dur, Maïbèche-Coisne, Martine, Lucas, Philippe, François Adrien, Thomas Chertemps, Maïbèche-Coisne Martine, Adrien François, Durand Nicolas, Dekker, Teun, Rosell Gloria, Teun Dekker, Chertemps Thomas, Martine Maïbèche-Coisne, Lucas Philippe, François, Adrien, Gloria Rosell, Sveriges lantbruksuniversitet., Dekker, Teun,   +25 more
core   +1 more source