Results 71 to 80 of about 7,996,985 (259)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Dataset Cocoa_under_water stress - physiological response Data

, 2020
This dataset contains the physiological and biochemical response of cocoa seedlings to a water stress treatment. The dataset has be described in the Article "The effect of short-term vs.
Glawe, Alexandra, Karlovsky, Petr, Pfohl, Katharina, Schneider, Monika, Niether, Wiebke, Pawelzik, Elke   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Physiological and Multi-Omics Insights into Drought Adaptation of Poacynum hendersonii Seedlings Under Different Water Deficit Regimes

Agronomy
This study used Poacynum hendersonii (Hook. f.) Woods. seedlings as experimental material. A soil drought group (gradual soil drying) and a PEG-simulated drought group (15% PEG-6000 treatment) were established.
Yongqian Jia, Ya Ding, Qian Wu, Yuehua Yu, Zhiyi Cheng, Zhongwei Wang, Hao Ma   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

SA regulates seed germination and growth in a dose-dependent manner in Nicotiana alata under salt stress

上海师范大学学报. 自然科学版
Using the modified Nicotiana alata as the test material, the seed germination and plant germination of Nicotiana alata under different concentration gradient exogenous salicylic acid (SA) treatments under 150 mmol·L-1 NaCl stress were studied.
ZHANG Ren, MING Jianlin, LIU Pengcheng, MING Feng   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Physiological response of glutamine and glutamic acid supplemented broiler chickens to heat stress [PDF]

, 2015
This study was conducted to investigate the effects of dietary glutamine (Gln) + glutamic acid (Glu) supplementation on growth performance and physiological stress response broilers exposed to cyclic heat stress.
Soleimani, Abdoreza Farjam, Olubodun, Joshua Omolayo, Idrus, Zulkifli, Bejo, Mohd Hair, Kasim, Azhar, null J. Olubodun, null A. Kasim, null M. Hair-Bejo, null I. Zulkifli, null A.F. Soleimani   +9 more
core   +1 more source