Results 71 to 80 of about 7,637,456 (312)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Applied SciencesThe use of personal protective equipment (PPE) for virus handling has the side effect of heat stress, which requires intervention to improve. This study aimed to evaluate the comfort of a newly designed PPE ensemble for virus handling. Three types of PPE
Totong Totong +3 more
doaj +1 more source
Tissue physiology and the response to heat
International Journal of Hyperthermia, 2006 The most important physiological parameter influencing tissue response to heat is blood flow. At mild hyperthermia temperatures blood perfusion increases in many tumours and this effect is heating time-, temperature- and tumour-dependent. These flow increases can improve tumour oxygenation. When heating is terminated, perfusion and oxygenation commonly
openaire +3 more sources
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Defence abuse response taskforce: final report [PDF]
, 2016 Executive summary The Taskforce was established on 26 November 2012 to assist complainants who had suffered sexual abuse, physical abuse, sexual harassment and workplace harassment and bullying in Defence prior to 11 April 2011.
Defence Abuse Response Taskforce
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Spectral reflectance and physiological studies of cocoa leaves in response to macronutrient deficiency [PDF]
, 2018 In cocoa (Theobroma cacao), macronutrients of nitrogen (N), phosphorus (P) and potassium (K) are the essential elements that may drastically affect growth, appearance and most importantly, yield.
Tee, Yei Kheng +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Editorial: Physiological Mini-Reviews, failure or success?
, 2022 The first number of “Physiological Mini-Reviews” was published in august 2005. After the first 20 issues, which were published both in the electronic and “on paper” version, we think that an initial assessment can be made. Physiological Mini-Reviews was
Physiological Mini-Reviews
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Physiological response of bacillus licheniformis NCIMB 8874to oligosaccharide elicitors [PDF]
, 2012 The mechanism by which certain oligosaccharides elicit overproduction of secondary metabolites in Bacillus licheniformis was investigated. Mannan oligosaccharides (MO) derived from locust bean gum, and oligoguluronate (OG) and oligomannuronate (OM) from ...
Reffatti, P.
core +1 more source