Results 131 to 140 of about 2,897 (211)
Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
Cléia Rocha de Sousa Feitosa +17 more
wiley +1 more source
Establishing the Dissolution Bioequivalence Safe Space for Immediate Release Formulation of Baclofen using Physiologically based Biopharmaceutics Modeling [PDF]
Clinical bioequivalence assessment is one of the critical aspects in the product development, since these studies are helpful in establishing the equivalence between a generic product and its reference-listed drug as per regulatory requirements ...
Anuj K. Saini*, Mukesh Gupta1 and Ajay Lale
core +2 more sources
Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1179-1194, May 2026.Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott +7 more
wiley +1 more source
Curcumin Nanoformulations for Dermatological Applications: From Nutraceuticals to Nanocarriers
Food Frontiers, Volume 7, Issue 3, May 2026.Nanotechnology‐based delivery platforms enhance the cutaneous administration of curcumin. Loading free curcumin into polymeric micelles, metal‐based nanoparticles, nanogels/hydrogels, liposomes, polymeric nanoparticles, or nanoemulsions/nanocrystals helps address its low solubility, poor stability and limited skin permeation. As a result, these systems
Stephany Celeste Gutiérrez‐Ruiz +13 more
wiley +1 more source
Quantitative Real‐Time MRI for the Assessment of Gastric Motility
Journal of Magnetic Resonance Imaging, Volume 63, Issue 5, Page 1482-1495, May 2026.ABSTRACT Background Current reference standards for measuring gastric emptying and motility are not considered optimal due to the time required, ionizing radiation, invasiveness, and spatial resolution. Purpose To assess gastric motility using novel real‐time dynamic magnetic resonance imaging in combination with static measurements for gastric ...
Lydia Neubauer +14 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
wiley +1 more source
The Structure of the Chemotype Determining Locus in Cannabis sativa
Plant Direct, Volume 10, Issue 5, May 2026.ABSTRACT The chemical phenotype (chemotype) of Cannabis sativa is defined by the ratio of cannabidiolic acid (CBDA) to Δ9‐tetrahydrocannabinolic acid (THCA). Although the Mendelian segregation of these traits suggests a single‐locus biallelic system, recent sequencing and phylogenetic evidence indicate they are encoded by two distinct, tightly linked ...
Keith Allen +2 more
wiley +1 more source
Disc‐Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery
Small, Volume 22, Issue 26, 8 May 2026.This study demonstrates sub‐50 nm solid‐lipid nanoparticles with long‐term stability, high drug loading, and strong tissue compatibility. Disc‐toroid morphology is confirmed and may play a role in cellular interactions, while low cytotoxicity and minimal systemic permeation confirm depot‐like behavior. These nanoparticles represent a versatile platform
Zanelle van Niekerk +9 more
wiley +1 more source
Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1
British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim +10 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 2049-2060, May 2026.Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma +9 more
wiley +1 more source