Results 131 to 140 of about 826 (178)

Development of a Physiologically Based Pharmacokinetic (PBPK) Simulation Model for Nicotine. [PDF]

Biopharm Drug Dispos
Kim B, Bae SH, Bashar M, Yi B, Rahman MA, Awuah P, Hartog M, Panarsky R, Zhang T.   +8 more
europepmc   +1 more source

Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference. [PDF]

CPT Pharmacometrics Syst Pharmacol
Dallmann A, Feick D, Balazki P, Benamara S, Burghaus R, Chenel M, Choi SL, Cordes H, Guimarães M, Hamadeh A, Ince I, Job KM, Kanacher T, Kovar A, Kuepfer L, Lippert J, Macente J, Nauwelaerts N, Niederalt C, Peters S, Proença S, Sato M, Schaller S, Schlender JF, Schneider A, Sjögren E, Solodenko J, Staab A, Vrenken P, Wendl T, de Witte WEA, Teutonico D.   +31 more
europepmc   +1 more source

Classification system proposed to guide the design, development, regulatory approval, and scaling of long acting, small- and macro-molecule parenteral products (CS-BLAP). [PDF]

J Pharm Sci
Perazzolo S, Shen DD, Ho RJY.
europepmc   +1 more source

Global Trends in Integrating Machine Learning (ML) with Model-Informed Drug Development (MIDD): A Bibliometric and Systematic Review (2015-2025). [PDF]

Pharmaceutics
Dermawan D, Chtita S, Alotaiq N.
europepmc   +1 more source

Physiologically-Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges. [PDF]

CPT Pharmacometrics Syst Pharmacol
Yates JWT, Zientek M, Taskar KS, Lin W, Heimbach T, Willmann S, Rehmel J, Parrott N, Hanley M, Badee J, Chen Y, Cole S, De Zwart L, Haertter S, Jiang R, Kotsuma M, Liang G, Lin YW, Liu J, Ou Y, Rascher J, Shaik NA, Wahlstrom J, Wang X, Xiao G, Yee KL, Cheung SYA.   +26 more
europepmc   +1 more source

The Evolution and Future Directions of PBPK Modeling in FDA Regulatory Review. [PDF]

Pharmaceutics
Li Y, Sun H, Zhang Z.
europepmc   +1 more source

Evaluating the Impact of Intestinal Bile Salts on Drug Absorption Using PBPK Modeling: Case Studies With Efavirenz, Cinnarizine, and Posaconazole. [PDF]

CPT Pharmacometrics Syst Pharmacol
Al-Amiry Santos LG, Polak S, Yeo KR.
europepmc   +1 more source

State of Art of Dose Individualization to Support tacrolimus drug monitoring: What's Next? [PDF]

Transpl Int
Lloberas N, Fernández-Alarcón B, Vidal-Alabró A, Colom H.   +3 more
europepmc   +1 more source

SLC52A1 is a neofunctionalized primate urate transporter enabling intestinal urate secretion. [PDF]

J Biol Chem
Yamamoto S, Inoue K, Yasujima T, Takei H, Yamashiro T, Asai K, Matake I, Uchiyama S, Ohta K, Kishimoto H, Higuchi K, Anayama H, Asao Y, Hirabayashi H, Amano N, Shimizu T, Takada T, Tamura T, Wakai K, Kawamura Y, Nakayama A, Toyoda Y, Matsuo H, Yuasa H.   +23 more
europepmc   +1 more source

Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and its Regulatory Utility to Support Oral Drug Product Development and Harmonization. [PDF]

Pharm Res
Cheng YH, Thomas S, Tsang YC, Almeida S, Ashraf M, Fotaki N, Heimbach T, Patel N, Shah H, Jiang X, Kim MJ, Moody R, Rostami-Hodjegan A, Singh R, Zhao L, Babiskin A, Wu F.   +16 more
europepmc   +1 more source