Results 71 to 80 of about 2,897 (211)
Physiologically based modelling of nanoparticle biodistribution and biokinetics [PDF]
, 2016 To predict the toxicity of nanoparticles (1-100 nm), it is crucial to understand their biokinetics i.e. how they are taken up, distributed, dissolved and removed from the body.
Carlander, Ulrika
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen +4 more
wiley +1 more source
, 2017 Nearly a quarter of visits to the Emergency Department are for conditions that could have been managed via outpatient treatment; improvements that allow patients to quickly recognize and receive appropriate treatment are crucial.
Abrams, Daniel M. +5 more
core +2 more sources
EURL ECVAM Workshop on New Generation of Physiologically-Based Kinetic Models in Risk Assessment [PDF]
, 2017 The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) Strategy Document on Toxicokinetics (TK) outlines strategies to enable prediction of systemic toxicity by applying new approach methodologies (NAM).
Bessems, J +21 more
core +2 more sources
Pharmaceutical Research, 2020 PURPOSE: To demonstrate that oral drug absorption is terminated in finite time. To develop models based on biopharmaceutical/physiological and finite absorption time concepts.The models are based on i) the passive drug diffusion mechanism under the sink conditions principle ii) the rate limiting role of the drug's properties solubility and permeability
Panos Macheras, Pavlos Chryssafidis
openaire +3 more sources
Biotechnology and Bioengineering, EarlyView.ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai +9 more
wiley +1 more source
Biophysical studies in polymer therapeutics: the interactions of anionic and cationic PAMAM dendrimers with lipid monolayers [PDF]
, 2017 Understanding how polymers interact with biological membranes is important for the development of polymer based therapeutics and wider biomedical applications.
Aronson PS +6 more
core +1 more source
Gaussian Processes for Predictive QSAR Modeling of Chromatographic Processes
Biotechnology and Bioengineering, EarlyView.ABSTRACT Chromatography is a key unit operation in the biopharmaceutical manufacturing process used for protein purification and polishing. Design and optimization of these processes are resource‐intensive resulting from the complex combinatorial design space.
Harini Narayanan +7 more
wiley +1 more source
Recent developments in skin mimic systems to predict transdermal permeation [PDF]
, 2015 In recent years there has been a drive to create experimental techniques that can facilitate the accurate and precise prediction of transdermal permeation without the use of in vivo studies.
Waters, Laura J.
core +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan +4 more
wiley +1 more source