Results 91 to 100 of about 23,818,397 (163)
Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2713-2728, October 2026.ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco +8 more
wiley +1 more source
, 2018 Ulrika Carlander,1 Tshepo Paulsen Moto,2 Anteneh Assefa Desalegn,1 Robert A Yokel,3 Gunnar Johanson1 1Unit of Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden; 2Faculty of Health Sciences ...
Moto TP +4 more
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Microbial Hydrolysates as Amino Acid Source in Cell Culture Media for Cellular Agriculture
Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2520-2535, October 2026.ABSTRACT The high cost of cultivation media remains one of the barriers to the commercialization of cultivated meat. Current serum‐free media reduce reliance on fetal bovine serum but only achieve modest cost savings. Especially at larger scales (> 20 m3), pharmaceutical‐grade amino acids and recombinant proteins remain major cost drivers.
Jelle C. Hoek +3 more
wiley +1 more source
Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova +11 more
wiley +1 more source
Developmental Neurobiology, Volume 86, Issue 4, October 2026.ABSTRACT Maternal infection‐induced inflammation during pregnancy is associated with adverse neurodevelopment. Rytvela, an allosteric IL‐1 receptor antagonist, reduces IL‐1β‐mediated pathology in fetal rodents and sheep. However, its effects on TLR3‐mediated inflammation and subsequent offspring growth and behavior remain unclear. Using precocial spiny
Nhi T. Tran +7 more
wiley +1 more source
Physiologically based Pharmacokinetic Models under the Prism of the Finite Absorption Time Concept
, 2023 To date, mechanistic modeling of oral drug absorption has been achieved via the use of physiologically based pharmacokinetic (PBPK) modeling, and more specifically, physiologically based biopharmaceutics model (PBBM).
Wu, D. +3 more
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Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
BIOPHARMACEUTICS AND APPROACHES TO DRUG ABSORPTION ENHANCEMENT
Biopharmaceutics is a foundational discipline in pharmaceutical sciences that focuses on the interplay between drug physicochemical properties, formulation design, and physiological factors governing drug absorption and bioavailability.
Shradha. S. Mathpati +4 more
core +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.ABSTRACT Securidaca inappendiculata (SI) Hassk. is a traditional Chinese herbal medicine commonly used in Southern China for the treatment of rheumatoid arthritis (RA). However, its exact mechanism of action remains unclear. In this study, we evaluated the therapeutic effects of the SI‐derived compound 1,7‐dihydroxy‐3,4‐dimethoxyxanthone (XAN) in a ...
Yuyan Zhou +6 more
wiley +1 more source
Small, Volume 22, Issue 55, 1 October 2026.Poly(N‐acryloyl glycine) hydrogel microparticles were fabricated via droplet‐based microfluidics and in situ photopolymerization. Rheology and MQ‐NMR revealed pronounced effects of pH and Ca2+ on network constraints and chain mobility, governing extensive swelling.
Yusuf Dursun +5 more
wiley +1 more source