Results 91 to 100 of about 826 (178)

Pharmacokinetic Models to Characterize the Absorption Phase and the Influence of a Proton Pump Inhibitor on the Overall Exposure of Dacomitinib

, 2020
Introduction: Dacomitinib is an epidermal growth factor receptor (EGFR) inhibitor approved for the treatment of metastatic non-small cell lung cancer (NSCLC) in the first line in patients with EGFR activating mutations.
Jennifer Hibma, May Haughey, Joanna Masters, Weiwei Tan, Swan Lin, Ana Ruiz-Garcia, Jerry Li   +6 more
core   +1 more source

Highlight on the benefits of PBPK modeling: A link between drug properties and its in vivo performance [PDF]

, 2023
Physiologically based pharmacokinetic (PBPK) modeling or more recently also known as physiologically based biopharmaceutics modeling (PBBM) is a computer-aided (in silico) biopharmaceutical tool, designed to mechanistically describe bioperformance of a ...
Cvijić, Sandra
core  

Justification of widened dissolution specifications of an extended-release product using physiologically based biopharmaceutics modeling

Xenobiotica
Drug products meeting the dissolution specifications is crucial in order to ensure consistent clinical performance. However, in certain cases, wider dissolution specifications may be required based on product behaviour. While the justification of such wider specifications may be challenging from a regulatory context, approaches such as physiological ...
Adithya Karthik, Bhattiprolu, Sivacharan, Kollipara, Rajkumar, Boddu, Tausif, Ahmed   +3 more
openaire   +2 more sources

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Establishing the Dissolution Bioequivalence Safe Space for Immediate Release Formulation of Baclofen using Physiologically based Biopharmaceutics Modeling

Clinical bioequivalence assessment is one of the critical aspects in the product development, since these studies are helpful in establishing the equivalence between a generic product and its reference-listed drug as per regulatory requirements ...
Anuj K. Saini*, Mukesh Gupta1 and Ajay Lale
core   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Mechanistic study of physicochemical and biochemical processes affecting intestinal absorption of the sesquiterpene lactone nobilin from multi-component systems in the Caco-2 model [PDF]

, 2015
The overall aim of this work was to investigate the intestinal absorption of the sesquiterpene lactone nobilin from the flowers of Anthemis nobilis L.
Thormann, U.
core   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner

Small, EarlyView.
Polyion complex micelles composed of blends of ABA and AB block copolymers can form coacervates with a hexagonally packed cylinder nanostructure after heating. The resulting coacervates can release the micelles under physiological conditions in a zero‐order kinetics, possessing cargo proteins.
Takumi Egashira, Hiroshi Kamizawa, Yujiro Hamada, Wataru Fushimoto, Hiroshi Y. Yoshikawa, Yuji Higaki, Atsushi Takahara, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura   +9 more
wiley   +1 more source

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report

, 2019
This publication summarizes the proceedings of day 2 of a 3-day workshop on “Dissolution and Translational Modeling Strategies Enabling Patient-Centric Product Development.” Patient-centric drug product development from a drug product quality perspective
Seo, Paul, Heimbach, Tycho, Li, Min, Mitra, Amitava, Lin, Ho-Pi,, Mitra, Amitava,, Sjögren, Erik, Patel, Nikunjkumar,, Seo, Paul,, Tsakalozou, Eleftheria,, Morris, Denise,, Lin, Ho-Pi, Li, Min,, Kakhi, Maziar,, Sjögren, Erik,, Zhang, Xinyuan, Morris, Denise, Patel, Nikunjkumar, Pepin, Xavier,, Kakhi, Maziar, Olivares-Morales, Andres, Heimbach, Tycho,, Olivares-Morales, Andres,, Suarez, Sharp, Kesisoglou, Filippos, Suarez-Sharp, Sandra,, Holmstock, Nico,, Pepin, Xavier, Montague, Timothy, Montague, Timothy,, Holmstock, Nico, Zhang, Xinyuan,, Kesisoglou, Filippos,, Tsakalozou, Eleftheria   +33 more
core   +1 more source