Results 91 to 100 of about 2,897 (211)

Application des modèles physiologiques à l'analyse de données de toxicocinétique [PDF]

, 2004
National audienceToxicological studies aim at protecting human populations by quantifying the damages caused by exposure to chemical agents. The main objective of toxicokinetic studies is to describe the relationships between exposure and the effective ...
Bois, Frédéric Y., Micallef, Sandrine
core   +1 more source

International Frameworks Dealing with Human Risk Assessment of Combined Exposure to Multiple Chemicals [PDF]

, 2013
The development of harmonised terminology and frameworks for the human risk assessment of combined exposure to multiple chemicals (“chemical mixtures”) is an important area for EFSA and a number of activities have already been undertaken, i.e.
ATSDR (Agency for Toxic Substances and Disease Registry), ATSDR (Agency for Toxic Substances and Disease Registry), ATSDR (Agency for Toxic Substances and Disease Registry), ATSDR (Agency for Toxic Substances and Disease Registry), Bliss, Bois, Boobis, Boobis, Cheng, Conolly, Crépet, Dennison, Dorne, Dorne, EFSA (European Food Safety Authority), EFSA (European Food Safety Authority), EFSA (European Food Safety Authority), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Plant Protection Products and their Residues (PPR), EFSA Panel on Plant Protection Products and their Residues (PPR), EFSA Panel on Plant Protection Products and their Residues (PPR), EFSA Scientific Committee, EFSA Scientific Committee, EFSA Scientific Committee, EFSA Scientific Committee, EFSA Scientific Committee, Fan, Finney, Gerlowski, Haddad, Haddad, Himmelstein, IGHRC, Jacob, Jacobsen, Klaassen, Kortenkamp, Krishnan, Krishnan, Lee, Loewe, Mayeno, Meek, Moretto, Mumtaz, Muratov, National Research Council, OECD, Price, Refstrup, Rowland, Sarigiannis, Sasso, Teuschler, Teuschler, Timchalk, US‐EPA (U.S. Environmental Protection Agency), US‐EPA (U.S. Environmental Protection Agency), US‐EPA (U.S. Environmental Protection Agency), US‐EPA (U.S. Environmental Protection Agency), US‐EPA (U.S. Environmental Protection Agency), US‐EPA (U.S. Environmental Protection Agency), US‐EPA (U.S. Environmental Protection Agency), US‐EPA (U.S. Environmental Protection Agency), Van den Berg, Van den Berg, van Gestel, van Gestel, Verhaar, Wang, WHO, WHO (World Health Organization), WHO (World Health Organization), WHO (World Health Organization), Wolterink, Yang   +83 more
core   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Pharmacokinetics and Pharmacodynamics in Space [PDF]

The Pharmacokinetics and Pharmacodynamics Panel met on 29-30 Aug. 1988 at the Lunar and Planetary Institute in Houston, Texas to discuss pharmacokinetic and pharmacodynamic implications of space flight and make recommendations for operational and ...
Cintron, Nitza M., Putcha, Lakshmi
core   +1 more source

Toward the harmonization of bioequivalence guidelines in Europe: Commentary on the state of the art and future priorities under ICH M13A for immediate‐release oral forms

British Journal of Clinical Pharmacology, EarlyView.
Domenico Nocera, Giusi Forastiero, Andrea Logreco, Alessia Proietti, Antonio Galluccio, Carlotta Lunghi, Elisabetta Poluzzi, Fabrizio De Ponti   +7 more
wiley   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations

Bioengineering
The aim of this study was to investigate the influence of solid dispersion (SD) formulation factors on improvement of the bioavailability and pharmacokinetic profile of clopidogrel after peroral administration using an in vitro–in silico approach.
Ehlimana Osmanović Omerdić, Sandra Cvijić, Jelisaveta Ignjatović, Branka Ivković, Dragana Vasiljević   +4 more
doaj   +1 more source

Locally D-optimal Designs for Exponential Regression [PDF]

We study locally D-optimal designs for some exponential models that are frequently used in the biological sciences. The model can be written as an algebraic sum of two or three exponential terms.
Dette, Holger, Melas, Viatcheslav B., Wong, Weng Kee   +2 more
core  

SEURAT-1 Tools & Methods Catalogue [PDF]

, 2016
The SEURAT-1 methods are here collected together and reported in the format of the database service that ensures OECD compliant descriptions. The information provided for for each methods is provided as reported and publicly available in the EURL ECVAM ...
BERGGREN ELISABET, JANUSCH ROI Annett, RICHARZ ANDREA, SWIATEK AGNIESZKA LIDIA   +3 more
core   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source