Results 81 to 90 of about 2,897 (211)

Formulation studies for eliminating saliva carcinogenic acetaldehyde with L-cysteine containing chewing gum [PDF]

, 2012
Tobacco smoke is a major risk factor for the development of cancers in the upper parts of gastrointestinal tract. It has been estimated that the risk of oral cancer among smokers is 7 10 times higher than for never-smokers.
Kartal-Hodzic, Alma
core  

Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levels [PDF]

Quantitative structure–activity relationship (QSAR) studies and mechanistic mathematical modeling approaches have been independently employed for analysing and predicting the transport and distribution of small molecule chemical agents in living ...
Bai, Jane
core   +1 more source

Engineered Bacterial Ligand From Streptococcus pneumoniae on Macroporous Resins for Selective Affinity Capture of Secretory IgA

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Secretory immunoglobulin A (sIgA) is a promising emerging biopharmaceutical candidate, but it currently lacks a standardized platform for purification. To address this, a novel affinity chromatography resin was developed by immobilizing protein variants of the Streptococcus pneumoniae surface protein, SpsA, as an affinity ligand.
David Scheich, Andres Männik, Oliver Meikar, Joan Teyra, Laura Kibena, Sebastiaan Eeltink, Rainer Hahn, Alois Jungbauer, Nico Lingg   +8 more
wiley   +1 more source

Systems pharmacology modeling: an approach to improving drug safety [PDF]

, 2014
Advances in systems biology in conjunction with the expansion in knowledge of drug effects and diseases present an unprecedented opportunity to extend traditional pharmacokinetic and pharmacodynamic modeling/analysis to conduct systems pharmacology ...
Bai, Jane
core   +1 more source

Optimizing Pichia Pastoris Cell‐Free Protein Synthesis to Improve Economics

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cell‐free protein synthesis (CFPS) is a powerful and versatile platform that supports a wide range of applications, from fundamental studies of the genetic code to scalable and rapid protein production. The recently developed Pichia pastoris CFPS combines advantages of both prokaryotic and eukaryotic systems, including a rapid growth rate ...
Rui Wu, Igor Koop, Gavin Murugan, Thagshanen Thillairajah, Karen M. Polizzi   +4 more
wiley   +1 more source

Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles. [PDF]

, 2018
Cutaneous leishmaniasis (CL) is caused by several species of the protozoan parasite Leishmania, affecting an estimated 10 million people worldwide. Previously reported strategies for the development of topical CL treatments have focused primarily on drug
Croft, Simon L, Gaukel, Eric, Hauser, Deirdre, Jacobs, Robert T, Merchant, Tejal, Park, Seong Hee, Plattner, Jacob J, Randolph, Ryan, Schock, Sara, Van Bocxlaer, Katrien, Wring, Stephen A, Yardley, Vanessa   +11 more
core   +1 more source

Addressing Small Data Challenges in Biopharmaceutical Development and Manufacturing: A Mini Review of Multi‐Fidelity Techniques

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The growing demand for biopharmaceutical products reflects their effectiveness in medical treatments. However, developing new biopharmaceuticals remains a major bottleneck, often taking up to a decade before market approval. Machine learning (ML) models have the potential to accelerate this process, but their success depends on access to large
Mohammad Golzarijalal, Uwe Aickelin, Ellen Otte   +2 more
wiley   +1 more source

Transposer de l'animal à l'humain : les modèles pharmacocinétiques physiologiques [PDF]

, 1996
On utilise souvent la dose administrée aux animaux, ou le niveau environnemental, d'exposition des populations humaines, pour décrire la relation entre dose et risque de survenue d'effets toxiques. Cette dosimétrie suppose que la dose interne, effective,
Bernillon, Pascale, Bois, Frédéric Y., Hemon, Denis   +2 more
core   +1 more source

Translational Systems Pharmacology Studies in Pregnant Women [PDF]

, 2017
Pregnancy involves rapid physiological adaptation and complex interplay between mother and fetus. New analytic technologies provide large amounts of genomic, proteomic, and metabolomics data.
Gullapelli, Rakesh, Haas, David M., Quinney, Sara K.   +2 more
core   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source