Results 81 to 90 of about 20,264 (293)

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

Physiologically based pharmacokinetic modeling of POPs in Greenlanders

Environment International, 2014
Human exposure to persistent organic pollutants (POPs) and the potential health impact in the Arctic far from the emission sources have been highlighted in numerous studies. As a supplement to human POP biomonitoring studies, a physiologically based pharmacokinetic (PBPK) model was set up to estimate the fate of POPs in Greenlandic Inuit's liver, blood,
Christian Sonne, Kim Gustavson, Frank F. Rigét, Rune Dietz, Tanja Krüger, Eva C. Bonefeld-Jørgensen   +5 more
openaire   +3 more sources

Physiologically based pharmacokinetic (PBPK) model of enalapril

<p>This repository provides the enalapril physiologically based pharmacokinetic (PBPK) model.</p> <p>If you have any questions or problems please <a href="https://github.com/matthiaskoenig/enalapril-model/issues">open an issue</
König, Matthias, Palwankar, Shubhankar
core   +1 more source

Abstract 1503: A physiologically-based pharmacokinetic (PBPK) model of hydroxychloroquine

, 2017
Hydroxychloroquine (HCQ) is a lysotropic autophagy inhibitor that is being used in over 45 clinical trials either alone or in combination with another chemotherapeutic.
Keagan P. Collins, Daniel L. Gustafson, Kristen M. Jackson   +2 more
core   +1 more source

Development of physiologically based pharmacokinetic model for the immediate release ropinirole tablets

, 2021
Ropinirole is a dopamine receptor agonist with high inter-individual variability in pharma- cokinetic parameters. Physiologically based pharmacokinetic (PBPK) modeling allows predicting drug pharmacokinetic behavior while accounting for individual ...
Wiśniowska, Barbara, Shuklinova, Olha, Dorożyński, Przemysław, Bielecka, Zofia, Kulinowski, Piotr, Polak, Sebastian   +5 more
core   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Physiologically-Based Pharmacokinetic Predictions of Lorazepam Paediatric Clearance

, 2015
Drug clearance is an important pharmacokinetic parameter as it describes the rate of elimination of a drug from the body. The aim of this project was to develop a physiologically-based pharmacokinetic model, with the simulation program Simcyp, to predict
Calvier, Elisa, van Donge, Tamara
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

A physiologically-based pharmacokinetic model for the antibiotic ertapenem

Mathematical Biosciences and Engineering, 2016
Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections, which is part of a broader class of antibiotics called carbapenem. Unlike other carbapenems, ertapenem has a longer half-life and thus only has to be administered once a day.
Michele L. Joyner, Cammey C. Manning, Whitney Forbes, Michelle Maiden, Ariel N. Nikas   +4 more
openaire   +5 more sources