Results 231 to 240 of about 23,888,926 (291)

Physiologically Based Pharmacokinetic Modeling of Oxcarbazepine to Characterize Its Disposition in Children with Obesity. [PDF]

J Clin Pharmacol
Maglalang PD, Sinha J, Helfer VE, Edginton A, Zimmerman K, Hornik CD, Muller WJ, Rathore M, Benjamin DK, Chen JY, Anand R, Gonzalez D, Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee.   +12 more
europepmc   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling of Caffeine in Preterm Neonates: Influence of Renal Function and Impairment on Dosing. [PDF]

J Clin Pharmacol
Thomas N, Harer MW, Lim SY.
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling of Di(2-ethylhexyl) Adipate and Its Primary Metabolite, Mono(2-ethylhexyl) Adipate, in Rats, Incorporating Circulatory Topology-Based Multi-Tissue Metabolism and Lymphatic Absorption. [PDF]

Pharmaceutics
Yang E, Jeong YS, Kim M, Kim S, Chung SJ.   +4 more
europepmc   +1 more source

Application of Physiologically-Based Pharmacokinetic Modeling to Support Drug Labeling: Prediction of CYP3A4-Mediated Pirtobrutinib-Drug Interactions. [PDF]

CPT Pharmacometrics Syst Pharmacol
Tian DD, Hall SD, Chapman SC, Posada MM.
europepmc   +1 more source

Characterizing Apixaban Pharmacokinetics Through Physiologically-Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in Humans. [PDF]

CPT Pharmacometrics Syst Pharmacol
Tsuchitani T, Kou W, Tomi M, Sugiyama Y.
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling of Efavirenz Nanoparticles: from Animal Model to Human Extrapolation. [PDF]

ACS Omega
da Silva TM, Sarcinelli MA, Cunha Chaves MH, Dias AA, Patricio BFC, Prado LD, Tasso L, Duque MD, Rocha HVA.   +8 more
europepmc   +1 more source

Physiologically-Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges. [PDF]

CPT Pharmacometrics Syst Pharmacol
Yates JWT, Zientek M, Taskar KS, Lin W, Heimbach T, Willmann S, Rehmel J, Parrott N, Hanley M, Badee J, Chen Y, Cole S, De Zwart L, Haertter S, Jiang R, Kotsuma M, Liang G, Lin YW, Liu J, Ou Y, Rascher J, Shaik NA, Wahlstrom J, Wang X, Xiao G, Yee KL, Cheung SYA.   +26 more
europepmc   +1 more source

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Pharmacokinetics and Physiologically-Based Pharmacokinetic Modeling of Nanoparticles

Journal of Nanoscience and Nanotechnology, 2010
The worldwide commerce involving nanoparticles will soon reach $1 trillion and already we have more than 600 commercial products containing nanoparticles. Because nanoparticles are invisible and little is known about their toxicities, there has been concern about health effects in humans.
Raymond S H, Yang, Louis W, Chang, Chung Shi, Yang, Pinpin, Lin   +3 more
openaire   +2 more sources

Physiologically Based Pharmacokinetic Modeling of Nanoparticles

ACS Nano, 2010
Rapid expansion of nanoparticle research demands new technologies that will enable better interpretation of experimental data and assistance in the rational design of future nanoparticles. The use of physiologically based pharmacokinetic (PBPK) models may serve as powerful tools to meet these needs.
Li, Mingguang, Al-Jamal, Khuloud T, Kostarelos, Kostas, Reineke, Joshua   +3 more
openaire   +3 more sources