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Development of a Physiologically Based Pharmacokinetic Model for Hydroquinone
Toxicology and Applied Pharmacology, 2000Hydroquinone (HQ) produces nephrotoxicity and renal tubular adenomas in male F344 rats following 2 years of oral dosing. Female F344 and SD rats are comparatively resistant to these effects. Nephrotoxicity and tumorigenicity have been associated with a minor glutathione conjugation pathway following the oxidation of HQ to benzoquinone (BQ).
R A, Corley +4 more
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Structural Identifiability of Physiologically Based Pharmacokinetic Models
Journal of Pharmacokinetics and Pharmacodynamics, 2006When starting a project in drug kinetics it is necessary to test a priori whether there is sufficient information in the experimental input-output design to estimate unique values of internal rate constants. This is an important test if the pharmacokinetics of a drug are to be characterised in some way by the parameter values estimated from the ...
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Physiologically based pharmacokinetic models for anticancer drugs
Cancer Chemotherapy and Pharmacology, 1979The rationale and history of the development of physiologically based pharmacokinetic models are briefly reviewed in this paper. The methods of model construction and the previous application of this type of model to anticancer drugs are discussed. Future research should be focused on the following areas: (1) interspecies scaling, (2) the effects of ...
H S, Chen, J F, Gross
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Physiology-based pharmacokinetic modeling: ready to be used
Drug Discovery Today: Technologies, 2004Physiology-based pharmacokinetic (PBPK) modeling is well recognized as a technology for mechanistically simulating and predicting the fate of substances in a mammalian body. Today, the demand for this methodology is higher than ever. The pharma industry and regulatory agencies are looking for new methods, which help to speed up and increase the ...
Walter, Schmitt, Stefan, Willmann
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Whole-body physiologically based pharmacokinetic models
Expert Opinion on Drug Metabolism & Toxicology, 2007This review summarizes the most recent developments in and applications of physiologically based pharmacokinetic (PBPK) modeling methodology originating from both the pharmaceutical and environmental toxicology areas. It focuses on works published in the last 5 years, although older seminal papers have also been referenced.
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Physiologically Based Pharmacokinetic Modeling: Principles and Applications
Journal of Pharmaceutical Sciences, 1983Concentrations of bromophenol blue (I) in plasma, urine, and bile were determined spectrophotometrically after intravenous bolus injections and infusions in rats. The plasma concentrations were found to decrease monoexponentially after all doses except the highest, where the decrease was biexponential.
L E, Gerlowski, R K, Jain
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Physiologically Based Pharmacokinetic Modeling
2005Preface. Acknowledgments. Contributors. Chapter 1. Introduction: A Historical Perspective of the Development and Applications of PBPK Models. 1. Introduction. 2. A Historical Perspective. 2-1. Responses to Inhaled Compounds. 2-2. Pharmaceutical Applications. 2-3. Occupational and Environmental Applications. 2-4. Digital Computation and PBPK Modeling. 3.
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Development of a physiologically based pharmacokinetic model of paraquat
2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017Paraquat (N, N'-dimethyl-4,4'-bipyridium dichloride) is a potent and widely used herbicide in agricultural countries, including Thailand. The presence of this chemical in the body can lead to toxic effects in the liver, kidney, and lung. Pulmonary toxicity has been identified as the main cause of acute toxicity in animals and humans.
Manupat Lohitnavy +4 more
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Physiological-based pharmacokinetic modeling of endotoxin in the rat
Toxicology and Industrial Health, 2012We have previously measured the distribution and pharmacokinetics of biosynthetically radiolabeled endotoxin of Salmonella typhimurium following intraperitoneal (IP) dosing (200 μg/kg) in Sprague-Dawley rats. In our experiments, the fatty acid residues were labeled with 3 H and the ...
Joseph C, Hutter, Chung S, Kim
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Physiologically Based Pharmacokinetic Models in Developmental Toxicology
Risk Analysis, 1994The kinetics of disposition of drugs and environmental chemicals will be altered as a result of the rapid and pronounced anatomic and physiologic changes that occur during pregnancy. These include changes in maternal intestinal motility, pulmonary tidal volume and minute volume, cardiac output, and renal function as well as in maternal tissue and fluid
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