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Physiologically-based pharmacokinetic modeling of pyrene in the rat
Environmental Toxicology and Pharmacology, 1998The objective of the present study was to develop a physiologically-based model to simulate the oral and i.v. pharmacokinetics of pyrene in the rat. The physiologically-based pharmacokinetic (PBPK) model for pyrene consisted of the following tissue compartments: liver, lungs, adipose tissue, slowly perfused tissues, and richly perfused tissues ...
S, Haddad +4 more
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Physiologically based pharmacokinetic modelling of cefoperazone in paediatrics
British Journal of Clinical PharmacologyAimsCefoperazone is commonly used off‐label in the treatment of bacterial meningitis and sepsis in children, and the pharmacokinetic (PK) data are limited in this vulnerable population. The goal of this study was to develop a physiologically based pharmacokinetic (PBPK) model to predict pediatric cefoperazone exposure for rational dosing ...
Qiushi Wang +4 more
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A Physiologically Based Pharmacokinetic Model of Inorganic Arsenic
Regulatory Toxicology and Pharmacology, 1999This study presents a physiologically based pharmacokinetic model of inorganic arsenic disposition in humans. The model focuses on short-term exposures by the oral route. The model considers the four circulating species (AsIII, AsV, and two metabolites, i.e., monomethylarsenic (MMA) and dimethylarsenic (DMA)) in tissue groups.
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Physiological Parameter Values for Physiologically Based Pharmacokinetic Models
Toxicology and Industrial Health, 1997R P, Brown +4 more
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Machine learning and artificial intelligence in physiologically based pharmacokinetic modeling.
Toxicological Sciences, 2023Zhoumeng Lin, Wei-Chun Chou
exaly