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Physiologically-based pharmacokinetic simulation modelling
Advanced Drug Delivery Reviews, 2002Drug selection is now widely viewed as an important and relatively new, yet largely unsolved, bottleneck in the drug discovery and development process. In order to achieve an efficient selection process, high quality, rapid, predictive and correlative ADME models are required in order for them to be confidently used to support critical financial ...
George M, Grass, Patrick J, Sinko
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Innovations and Improvements in Pharmacokinetic Models Based on Physiology
Current Drug Delivery, 2017Background: Accompanied by significant improvements of modeling techniques and computational methods in medical sciences, the last thirty years saw the flourishing of pharmacokinetic models for applications in the pharmacometric field. In particular, physiologically based pharmacokinetic (PBPK) models, grounded
ABBIATI, ROBERTO ANDREA, MANCA, DAVIDE
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Physiologically Based Pharmacokinetic/Toxicokinetic Modeling
2012Physiologically based pharmacokinetic (PBPK) models differ from conventional compartmental pharmacokinetic models in that they are based to a large extent on the actual physiology of the organism. The application of pharmacokinetics to toxicology or risk assessment requires that the toxic effects in a particular tissue are related in some way to the ...
Jerry L, Campbell +4 more
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Physiologically Based Pharmacokinetic Modeling of Arsenic in the Mouse
Journal of Toxicology and Environmental Health, Part A, 2004A remarkable feature of the carcinogenicity of inorganic arsenic is that while human exposures to high concentrations of inorganic arsenic in drinking water are associated with increases in skin, lung, and bladder cancer, inorganic arsenic has not typically caused tumors in standard laboratory animal test protocols.
P Robinan, Gentry +5 more
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A physiologically based model for tramadol pharmacokinetics in horses
Journal of Theoretical Biology, 2017This work proposes an application of a minimal complexity physiologically based pharmacokinetic model to predict tramadol concentration vs time profiles in horses. Tramadol is an opioid analgesic also used for veterinary treatments. Researchers and medical doctors can profit from the application of mathematical models as supporting tools to optimize ...
Abbiati, Roberto Andrea +4 more
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Physiologically based pharmacokinetic model for topotecan in mice
Journal of Pharmacokinetics and Pharmacodynamics, 2010Topotecan is a chemotherapeutic agent of choice for the second-line treatment of recurrent ovarian cancer. In this article, we have developed a physiologically based pharmacokinetic model to characterize and predict topotecan concentrations in mouse plasma and tissues. Single intravenous (IV) doses (5, 10 and 30 mg/kg) of topotecan were administered to
Dhaval K, Shah, Joseph P, Balthasar
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Physiologically based pharmacokinetic modelling
2003AbstractThis chapter provides a general introduction to physiologically based pharmacokinetic (PBPK) modeling of exposure in occupational and environmental epidemiological studies. It describes models that could be used for the assessment. It provides various examples and references.
George Loizou, Martin Spendiff
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Physiologically-Based Pharmacokinetic Modeling and Bioactivation of Xenobiotics
Toxicology and Industrial Health, 1994This paper describes the development and implementation of physiologically-based pharmacokinetic (PB-Pk) models to examine the disposition of xenobiotics and their bioactivation. In a PB-Pk model, the structure of the model is based, to as great extent as practicable, on the actual physiological and biochemical structure of the animal system being ...
H J, Clewell, M E, Andersen
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Development of a physiologically based pharmacokinetic model for chloroform
Toxicology and Applied Pharmacology, 1990A physiologically based pharmacokinetic model describing the disposition of chloroform in mice, rats, and humans was developed. This model was designed to facilitate extrapolations from high doses, such as those used in chronic rodent studies, to low doses that humans may be exposed to in the workplace or the environment. Kinetic constants for mice and
R A, Corley +7 more
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Physiologically-Based Pharmacokinetic Modeling
Drug Information Journal, 1994Physiologically-based pharmacokinetic (PB-PK) models attempt to provide both a realistic anatomic description of the animal to which a drug or toxic chemical has been administered and a biologically accurate representation of the physiological pathways for chemical storage, metabolism, and elimination in the animal.
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