Results 181 to 190 of about 4,018 (220)
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Phytanic acid – a tetramethyl‐branched fatty acid in food
Lipid Technology, 2011AbstractPhytanic acid is a tetramethyl‐branched isoprenoid fatty acid. Its presence in food is linked with chlorophyll, which contains its precursor, i. e. the alcohol side‐chain phytol. The bioconversion of phytol into phytanic acid is effective particularly in the rumen and in the marine environment.
Walter Vetter, Markus Schröder
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Transport of Phytanic Acid on Lipoproteins in Refsum's Disease
Clinical Science, 1998AbstractPatients with Refsum disease accumulate significant quantities of phytanic acid in adipose and neural tissue. The accumulation can be reversed by following a diet low in phytanic acid, yet the mechanism of transport of this fatty acid is obscure.
A S, Wierzbicki +5 more
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NeuroMolecular Medicine, 2018
Docosahexaenoic acid (DHA, 22:6 n-3) is an essential omega-3 (ω-3) long chain polyunsaturated fatty acid of neuronal membranes involved in normal growth, development, and function. DHA has been proposed to reduce deleterious effects in neurodegenerative processes. Even though, some inconsistencies in findings from clinical and pre-clinical studies with
María Belén, Ruiz-Roso +8 more
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Docosahexaenoic acid (DHA, 22:6 n-3) is an essential omega-3 (ω-3) long chain polyunsaturated fatty acid of neuronal membranes involved in normal growth, development, and function. DHA has been proposed to reduce deleterious effects in neurodegenerative processes. Even though, some inconsistencies in findings from clinical and pre-clinical studies with
María Belén, Ruiz-Roso +8 more
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The stereochemistry of phytanic acid in Refsum's Syndrome
Lipids, 1970AbstractPhytanic acid has been isolated from the total lipids of the liver of a human suffering from the disease, Refsum's Syndrome (Heredopathia atactica polyneuritiformis). Optical rotation measurements were made on the acid, and on the ketone 6,10,14‐trimethylpentadecan‐2‐one which resulted from the oxidative degradation of the acid and the ...
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Phytanic acid—an overlooked bioactive fatty acid in dairy fat?
Annals of the New York Academy of Sciences, 2010Phytanic acid is a multibranched fatty acid with reported retinoid X receptor (RXR) and peroxisome proliferator‐activated receptor‐α (PPAR‐α) agonist activity, which have been suggested to have preventive effects on metabolic dysfunctions. Serum level in man is strongly correlated to the intake of red meat and dairy products and the concentration in ...
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Mammalian Metabolism of Phytanic Acid : Recent Findings
1988Phytanic acid, a xenobiotic compound, is a saturated C20 branched chain fatty acid which, because of the existence of a beta-methyl substitution cannot directly undergo beta-oxidation. A preliminary alpha-oxidizing decarboxylation takes place, after which the methyl group occupies the alpha position (1–4).
Jean-Pierre Draye +2 more
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Phytanic acid oxidase deficiency in childhood.
Clinical and experimental neurology, 1987Tables 2 and 5 summarize the major clinical and biochemical findings in these patients. Cases 1 and 2 resemble clinically the previous cases of children reported as suffering from infantile phytanic acid storage disease, Zellweger's disease, or neonatal adrenoleucodystrophy. Cases 3 and 4 differ strikingly from these and from one another.
G A, Wise +5 more
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Peroxisomal disorders affecting phytanic acid α-oxidation: a review
Biochemical Society Transactions, 2007Peroxisomes are involved in the synthesis and degradation of complex fatty acids. They contain enzymes involved in the α-, β- and ω-oxidation pathways for fatty acids. Investigation of these pathways and the diseases associated with mutations in enzymes involved in the degradation of phytanic acid have led to the clarification of the pathophysiology of
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Refsum’s Disease (Phytanic Acid Storage Disease)
1976In 1946, Sigvald Refsum defined a new, primarily neurologic syndrome, heredopathia atactica polyneuritiformis. The cardinal features of the syndrome included retinitis pigmentosa, peripheral polyneuropathy, cerebellar ataxia and elevated cerebrospinal fluid protein concentration without increase in cell number.
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The formation of alpha-hydroxy phytanic acid from phytanic acid in mammalian tissues
Biochemical and Biophysical Research Communications, 1967S C, Tsai +4 more
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