Results 41 to 50 of about 2,517,871 (188)

Characterization of phytanic acid omega-hydroxylation in human liver microsomes

, 2005
Phytanic acid is a 3-methyl branched-chain fatty acid which originates from dietary sources. Since the 3-methyl group blocks regular beta-oxidation, it is broken down by peroxisomal alpha-oxidation.
Komen, J. C., Duran, M., Wanders, R. J. A.   +2 more
core   +1 more source

Phytanic acid alpha-oxidation: accumulation of 2-hydroxyphytanic acid and absence of 2-oxophytanic acid in plasma from patients with peroxisomal disorders.

Journal of Lipid Research, 1992
A stable isotope dilution method was developed for the measurement of 2-hydroxyphytanic acid and 2-oxophytanic acid in plasma. In plasma from healthy individuals and from patients with Refsum's disease, 2-hydroxyphytanic acid was found at levels less ...
HJ ten Brink, DS Schor, RM Kok, BT Poll-The, RJ Wanders, C Jakobs   +5 more
doaj   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

Improved electroretinographic responses following dietary intervention in a patient with Refsum disease

JIMD Reports, 2020
Refsum disease is a rare inherited metabolic disorder arising from a defect in peroxisomal metabolism. Patients lack the functional enzyme phytanoyl‐CoA hydroxylase, resulting in perturbed alpha oxidation of fatty acids.
Matthew D. Benson, Ian M. MacDonald, Melissa Sheehan, Shailly Jain   +3 more
doaj   +1 more source

Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism

Scientific Reports, 2022
Peroxisomes play an important role in the metabolism of a variety of biomolecules, including lipids and bile acids. Peroxisomal Membrane Protein 4 (PXMP4) is a ubiquitously expressed peroxisomal membrane protein that is transcriptionally regulated by ...
Maaike Blankestijn, Vincent W. Bloks, Dicky Struik, Nicolette Huijkman, Niels Kloosterhuis, Justina C. Wolters, Ronald J. A. Wanders, Frédéric M. Vaz, Markus Islinger, Folkert Kuipers, Bart van de Sluis, Albert K. Groen, Henkjan J. Verkade, Johan W. Jonker   +13 more
doaj   +1 more source

Peroxisomal Lipid Metabolism as a Therapeutic Target in Leukemia

Molecular Nutrition &Food Research, Volume 70, Issue 11, 15 June 2026.
Peroxisomes are emerging as key regulators of lipid metabolism in leukemia. Enhanced metabolism of very‐long‐chain fatty acids (VLCFAs) supports leukemia cell survival, redox homeostasis, and therapeutic resistance. Pharmacologic disruption of peroxisomal fatty acid oxidation causes VLCFA accumulation, oxidative stress, and mitochondrial dysfunction ...
Ekaterina N. Parfenova, Paul A. Spagnuolo   +1 more
wiley   +1 more source

Sterol carrier protein-2/sterol carrier protein-x expression differentially alters fatty acid metabolism in L cell fibroblasts

Journal of Lipid Research, 2003
Sterol carrier protein-2 (SCP-2) and SCP-x are ubiquitous proteins found in all mammalian tissues. Although both proteins interact with fatty acids, their relative contributions to the uptake, oxidation, and esterification of straight-chain (palmitic ...
Barbara P. Atshaves, Stephen M. Storey, Friedhelm Schroeder   +2 more
doaj   +1 more source

Fats, Fire and Bronze Age Funerary Rites: Organic Residue Analysis of Wide Horizontal Rim Vessels From Burial Contexts in Northwest Portugal

Archaeometry, Volume 68, Issue 3, Page 298-310, June 2026.
ABSTRACT This study presents the first GC‐MS–based analyses of wide horizontal rim vessels with well‐defined funerary contexts, from Middle Bronze Age Portugal (Quinta do Amorim 2 and Pego). Organic residues from two vessels revealed ruminant fats and plant oils, alongside molecular markers of heat exposure.
João Vinícius Back, César Oliveira, Ana M. S. Bettencourt, Hugo Aluai Sampaio, Luciano Vilas Boas, Luís Gonçalves   +5 more
wiley   +1 more source

Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions [PDF]

, 2010
Background It has been proposed that anatomical differences in human and great ape guts arose in response to species-specific diets and energy demands.
Steinberg, Steven J, Moser, Ann B, Hacia, Joseph G, Krishna Ramaswamy, Oliver A Ryder, Moser, Hugo W, Ryder, Oliver A, Karaman, Mazen W, John J Ely, Mazen W Karaman, Cicely B Toomer, Hugo W Moser, Kimberly D Siegmund, Toomer, Cicely B, Steven J Steinberg, Siegmund, Kimberly D, Ann B Moser, Watkins, Paul A, Lee, D Rick, Ramaswamy, Krishna, Joseph G Hacia, Paul A Watkins, D RICK Lee, Ely, John J   +23 more
core   +1 more source

Comparison of the antibacterial activity, volatiles and fatty acid composition of lipids of Phycopsis species collected at different locations from the Bay of Bengal (Orissa coast) [PDF]

Journal of the Serbian Chemical Society, 2009
The fatty acid composition as well as the volatiles and an antibacterial screening of the total lipids isolated from marine sponge Phycopsis sp.
PRAVAT MANJARI MISHRA, AYINAMPUDI SREE
doaj   +3 more sources