Results 61 to 70 of about 2,517,871 (188)

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Phytanoyl‐CoA hydroxylase activity is induced by phytanic acid [PDF]

European Journal of Biochemistry, 2000
Phytanic acid (3,7,11,15‐tetramethylhexadecanoic acid) is a branched‐chain fatty acid present in various dietary products such as milk, cheese and fish. In patients with Refsum disease, accumulation of phytanic acid occurs due to a deficiency of phytanoyl‐CoA hydroxylase, a peroxisomal enzyme containing a peroxisomal targeting signal 2.
Zomer, A. W., Jansen, G. A., van der Burg, B., Verhoeven, N. M., Jakobs, C., van der Saag, P. T., Wanders, R. J., Poll-The, B. T.   +7 more
openaire   +3 more sources

Solvent‐Mediated Microphase Separation in Ionogels for the Construction of Mechanically Robust and High‐Energy‐Output Moisture‐Electric Generators

Interdisciplinary Materials, Volume 4, Issue 6, Page 869-880, November 2025.
The environmentally adaptable polyacrylamide‐based gel moisture‐electric generator (PAB–MEG) was developed with high mechanical strength and energy output by innovatively designing a microphase‐separated double‐network ionogels structure. In this structure, the solvent‐rich phase facilitates stretching and ionic conduction, whereas the polymer‐rich ...
Ying Wang, Jiaqi Chai, Hongji Wang, Tianliang Xiao, Jiazheng Zhao, Lie Chen, Wenwei Lei, Mingjie Liu   +7 more
wiley   +1 more source

A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARα-dependent and -independent pathways

Journal of Lipid Research, 2005
Branched-chain fatty acids (such as phytanic and pristanic acid) are ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα) in vitro.
J. Gloerich, N. van Vlies, G.A. Jansen, S. Denis, J.P.N. Ruiter, M.A. van Werkhoven, M. Duran, F.M. Vaz, R.J.A. Wanders, S. Ferdinandusse   +9 more
doaj   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1383-1408, November 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16431 Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment.
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source

On the origin of pristane in marine organisms

Journal of Lipid Research, 1968
Phytol-U-14C was adsorbed on algae and ingested in this form by zooplanktonic copepods (two species of Calanus). The lipids of these animals were analyzed after 48 hr and found to contain radioactive pristane and radioactive phytanic acid. The conversion
Joel Avigan, Max Blumer
doaj   +1 more source

Characterisation of a Self‐Sufficient Cytochrome P450 Enzyme From the Bacterium Thermosporothrix hazakensis and Its Conversion Into a Peroxygenase

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
A cytochrome P450 enzyme from the thermophile Thermosporothrix hazakensis was characterised. We modified the heme domain of the enzyme through protein engineering to enable it to function as a peroxygenase biocatalyst. We demonstrated the oxidation of fatty acids and aromatic compounds and identified the metabolites.
Matthew N. Podgorski, Joel H. Z. Lee, Jarred M. Scaffidi‐Muta, Jinia Akter, Stephen G. Bell   +4 more
wiley   +1 more source

Natural occurrence of cancer-preventive geranylgeranoic acid in medicinal herbs

Journal of Lipid Research, 2004
Geranylgeranoic acid (GGA; all-trans 3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenoic acid) has been shown to induce apoptosis in a human hepatoma-derived cell line, HuH-7.
Yoshihiro Shidoji, Hiroko Ogawa
doaj   +1 more source

Treatment of Inborn Errors by Product Replacement: The Example of Inborn Errors of Bile Acid Synthesis

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Many inborn errors of metabolism affect pathways involved in the synthesis of a metabolite that has an important biochemical or physiological function, and adverse effects of the disorder can be attributed to the lack of this metabolite. Thus, there is the opportunity for treatment by ‘product replacement’. One of the disorders in the pathways
Peter T. Clayton, Rohit Hirachan, Elaine Murphy   +2 more
wiley   +1 more source

Refsum disease, peroxisomes and phytanic acid oxidation: a review

, 2001
Refsum disease was first recognized as a distinct disease entity by Sigvald Refsum in the 1940s. The discovery of markedly elevated levels of the branched-chain fatty acid phytanic acid in certain patients marked Refsum disease as a disorder of lipid ...
Jansen, G. A., Wanders, R. J., Skjeldal, O. H.   +2 more
core   +1 more source