Results 211 to 220 of about 170,611 (285)

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Do honey phytochemicals modulate forager aggression and the gut microbiome in the honey bee (Apis mellifera L.)? [PDF]

Biol Open
Pike WA, Stephens J, Donohue M, Rajandran K, Treanore ED, Sher A, Croteau E, Rittschof CC.   +7 more
europepmc   +1 more source

Natural‐based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications

International Journal of Cosmetic Science, EarlyView.
Natural antioxidants from plants, fruits, seeds and fungi combat ageing by neutralizing free radicals, boosting collagen and protecting against UV damage. Enhanced by green extraction and smart delivery systems, they offer powerful anti‐inflammatory and antimicrobial benefits.
Hossein Omidian, Arnavaz Akhzarmehr, Charise Dallazem Bertol   +2 more
wiley   +1 more source

Harnessing the anticancer potential of <i>Moringa oleifera</i>: a safer, multi-targeted adjunct. [PDF]

Ann Med Surg (Lond)
Abro F, Kumar N, Nitasha, Kumari S, Qazi S, Khan MS, Waafira A.   +6 more
europepmc   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source

Phytochemicals Prime RIG-I Signaling and Th1-Leaning Responses in Human Monocyte-Derived Dendritic Cells. [PDF]

Nutrients
Ohki K, Iwasawa T, Kato K.
europepmc   +1 more source

Impact of Different Dosage Forms of Orally Administered Chinese Herbal Medicine on Treatment and Adverse Effect Estimates in Randomized Controlled Trials: A Meta‐Epidemiological Study

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Aim In traditional Chinese medicine, different dosage forms of orally administered Chinese herbal medicine (CHM) may introduce bias in estimating treatment and adverse effects. This meta‐epidemiological study aimed to evaluate whether the use of different orally administered CHM dosage forms is associated with overestimation or underestimation
Claire Chenwen Zhong, Betty Huan Wang, Mary Yue Jiang, Leonard Ho, Fai Fai Ho, Irene Xin Yin Wu, Yin Ting Cheung, Vincent Chi Ho Chung   +7 more
wiley   +1 more source

Evaluation of Safety and Antigenotoxic Activity of <i>Rosa centifolia</i> Extract, Kaempferol, and Kaempferol-3-glucoside against Ultraviolet B Radiation in Human Fibroblasts. [PDF]

ACS Omega
Barrios Martínez SX, Sierra Prada LJ, Ocazionez RE, Stashenko EE, Vinardell MP, Fuentes JL.   +5 more
europepmc   +1 more source

Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context

Journal of Integrative Plant Biology, EarlyView.
Evolutionary gains and losses of key biosynthetic genes likely resulting from multiple independent evolutionary events explain why certain Nepeta (catnip) species produce both the active, cat‐attracting nepetalactones and sugar‐bound iridoids, while others make only the sugar‐bound forms, and some have lost iridoid production entirely.
Tijana Banjanac, Milica Milutinović, Dragana Matekalo, Neda Popović, Luka Petrović, Uroš Gašić, Marijana Skorić, Branislav Šiler, Tamara Lukić, Ana Stupar, Slavica Dmitrović, Jasmina Nestorović Živković, Biljana Filipović, Jelena Božunović, Miloš Todorović, Danijela Mišić   +15 more
wiley   +1 more source