Plant-type phytoene desaturase: Functional evaluation of structural implications. [PDF]
PLoS ONE, 2017 Phytoene desaturase (PDS) is an essential plant carotenoid biosynthetic enzyme and a prominent target of certain inhibitors, such as norflurazon, acting as bleaching herbicides.
Julian Koschmieder +6 more
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A new F131V mutation in Chlamydomonas phytoene desaturase locates a cluster of norflurazon resistance mutations near the FAD-binding site in 3D protein models. [PDF]
PLoS ONE, 2014 The green alga Chlamydomonas reinhardtii provides a tractable genetic model to study herbicide mode of action using forward genetics. The herbicide norflurazon inhibits phytoene desaturase, which is required for carotenoid synthesis.
Julio V Suarez +3 more
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Marine DrugsThe formation of phytoene by condensing two geranylgeranyl diphosphate molecules catalyzed by phytoene synthase (PSY) is the first committed and rate-limiting step in carotenoid biosynthesis, which has been extensively investigated in bacteria, land ...
Cheng-Ling Li +6 more
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Phytoene Desaturase from Oryza sativa: Oligomeric Assembly, Membrane Association and Preliminary 3D-Analysis. [PDF]
PLoS ONE, 2015 Recombinant phytoene desaturase (PDS-His6) from rice was purified to near-homogeneity and shown to be enzymatically active in a biphasic, liposome-based assay system. The protein contains FAD as the sole protein-bound redox-cofactor.
Sandra Gemmecker +9 more
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A comprehensive review on the colorless carotenoids phytoene and phytofluene [PDF]
Archives of Biochemistry and Biophysics, 2015 Carotenoids and their derivatives are versatile isoprenoids involved in many varied actions, hence their importance in the agri-food industry, nutrition, health and other fields. All carotenoids are derived from the colorless carotenes phytoene and phytofluene, which are oddities among carotenoids due to their distinct chemical structure.
Meléndez Martínez, Antonio Jesús +3 more
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The Bacterial Phytoene Desaturase-Encoding Gene (CRTI) is an Efficient Selectable Marker for the Genetic Transformation of Eukaryotic Microalgae [PDF]
Metabolites, 2019 Genetic manipulation shows great promise to further boost the productivity of microalgae-based compounds. However, selection of microalgal transformants depends mainly on the use of antibiotics, which have raised concerns about their potential impacts on
Ana Molina-Márquez +4 more
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Functional analysis of the Phycomyces carRA gene encoding the enzymes phytoene synthase and lycopene cyclase. [PDF]
PLoS ONE, 2011 Phycomyces carRA gene encodes a protein with two domains. Domain R is characterized by red carR mutants that accumulate lycopene. Domain A is characterized by white carA mutants that do not accumulate significant amounts of carotenoids. The carRA-encoded
Catalina Sanz +4 more
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Brazilian Archives of Biology and Technology, 2018 Phytoene synthase (PSY) is the rate-limiting enzyme for carotenoid biosynthesis. To date, several studies focused on PSY genes in the context of abiotic stress responses.
Huanhuan Shao +8 more
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Dietary carotenoids and breast cancer risk: evidence from a large population-based incident case-control study [PDF]
Nutrition & MetabolismBackground Although mechanistic studies suggest protective roles for carotenoids against breast cancer (BC), human studies yield inconsistent findings. Few have comprehensively evaluated dietary intake of individual and grouped carotenoids in relation to
Bahar Darouei +6 more
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cDNA cloning and expression analyses of phytoene synthase 1, phytoene desaturase and ζ-carotene desaturase genes from Solanum lycopersicum KKU-T34003 [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2013 We report on the cloning of Psy1, Pds and Zds cDNAs encoding the enzymes responsible for lycopene biosynthesis,namely phytoene synthase 1 (PSY1), phytoene desaturase (PDS) and -carotene desaturase (ZDS), respectively, from high-lycopene tomato cultivar,
Krittaya Supathaweewat +1 more
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