Results 101 to 110 of about 5,394 (197)

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. [PDF]

, 2015
The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL).
Ale-Ali, Amine, Amaya-Chanaga, Carlos I, Cardarelli, Pina M, Castro, Januario E, Choi, Michael Y, Cohen, Lewis J, Jones, Harrison, Kashyap, Manoj K, Kipps, Thomas J, Kuhne, Michelle R, Kumar, Deepak, Melo-Cardenas, Johanna, Rassenti, Laura Z, Sabbatini, Peter, Shelat, Suresh G   +14 more
core   +2 more sources

Saccharomyces cerevisiae depend on vesicular traffic between Golgi and vacuole when Inositolphosphorylceramide synthase Aur1 is inactivated [PDF]

, 2015
Inositolphosphorylceramide (IPC) and its mannosylated derivatives are the only complex sphingolipids of yeast. Their synthesis can be reduced by aureobasidin A (AbA), which specifically inhibits the IPC synthase Aur1.
Conzelmann, Andreas, Ejsing, Christer S, Mallela, Shamroop K, Roubaty, Carole, Vazquez, Hector M, Voynova, Natalia S   +5 more
core   +2 more sources

Erythrocyte and porcine intestinal glycosphingolipids recognized by F4 fimbriae of enterotoxigenic Escherichia coli.

PLoS ONE, 2011
Enterotoxigenic F4-fimbriated Escherichia coli is associated with diarrheal disease in neonatal and postweaning pigs. The F4 fimbriae mediate attachment of the bacteria to the pig intestinal epithelium, enabling an efficient delivery of diarrhea-inducing
Annelies Coddens, Erik Valis, John Benktander, Jonas Ångström, Michael E Breimer, Eric Cox, Susann Teneberg   +6 more
doaj   +1 more source

Synthesis of the cytotoxic phytosphingosines and their isomeric analogues

Carbohydrate Research, 2018
A straightforward synthesis of l-lyxo- and l-xylo-phytosphingosine along with their isomeric analogues has been accomplished. The salient features of this approach are the utilization of [3,3]-sigmatropic rearrangements to install a C-N bond and application of a late stage Wittig or OCM reaction to incorporate the hydrophobic chain unit.
Jana Špaková Raschmanová, Miroslava Martinková, Jozef Gonda, Martina Bago Pilátová, Daniel Kupka, Dávid Jáger   +5 more
openaire   +3 more sources

Structural, mechanistic and regulatory studies of serine palmitoyltransferase [PDF]

, 2012
SLs (sphingolipids) are composed of fatty acids and a polar head group derived from l-serine. SLs are essential components of all eukaryotic and many prokaryotic membranes but S1P (sphingosine 1-phosphate) is also a potent signalling molecule.
Alexeev, An, Astner, Bejaoui, Bourquin, Breslow, Buede, Dietrich, Dominic J. Campopiano, Eliot, Fahy, Gable, Gable, Gable, Garofalo, Geiger, Han, Han, Han, Hanada, Hanada, Hanada, Hjelmqvist, Hojjati, Hornemann, Hornemann, Huang, Ikushiro, Ikushiro, Ikushiro, Jahan, James H. Naismith, Jonathan Lowther, Kawahara, Kelly, Lowther, Lowther, Merrill, Mun, Nagiec, Nagiec, Penno, Raman, Raman, Roelants, Rotthier, Schmidt, Shiraiwa, Snell, Teresa M. Dunn, Ternes, Weiss, Williams, Yard, Yim, Zhao, Zitomer   +56 more
core   +1 more source

Structure and composition of sulfatides isolated from livers of patients with metachromatic leukodystrophy: galactosyl sulfatide and lactosyl sulfatide

Journal of Lipid Research, 1974
The livers of four patients with metachromatic leukodystrophy contained galactosyl sulfatide and lactosyl sulfatide, whereas these substances were undetectable in normal human liver.
Mutsumi Sugita, John T. Dulaney, Hugo W. Moser   +2 more
doaj   +1 more source

Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library [PDF]

, 2017
Additional file 1. Figure S1 The fragment assignments of 12 sphingolipid classes. The annotations were combinatorially performed by hydrogen rearrangement rules in combination with substantial manual curation.
Hiroshi Tsugawa, Kazutaka Ikeda, Makoto Arita, Masanori Arita, Wataru Tanaka, Yuya Senoo   +5 more
core   +5 more sources

Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James [PDF]

, 2014
Alzheimer’s disease (AD) is the most common form of dementia. Until recently, AD is managed by relieving the cognitive symptoms without addressing one of the purportedly fundamental causes of the disease which is the formation of the amyloid plaques. The
James, Richard Muhammad Johari
core  

Comparison of the Antimicrobial Properties of Nanoemulsions Made from Phytosphingosine and Chitosan with a Triple Antibiotic Paste Against Enterococcus faecalis in Endodontics: An in-vitro Study

International Journal of Nanomedicine
Ganesh R Jadhav,1,* Priya Mittal,2,* Mohammed Abdul Kader M,3 Suheel Manzoor Baba,3 Siddharth Shinde,4 Dhanashree Dalal,5 Ahmed Abdullah Al Malwi,3 Shahabe Saquib Abullais,6 Siddharthan Selvaraj7,8 1Department of Dentistry, All India ...
Jadhav GR, Mittal P, Abdul Kader M M, Baba SM, Shinde S, Dalal D, Al Malwi AA, Abullais SS, Selvaraj S   +8 more
doaj  

The Effect of a Phytosphingosine-like Substance Isolated from on Involucrin Expression in Mite Antigen-Stimulated HaCaT Cells

Natural Product Communications, 2010
The aim of the present study was to investigate the effect of phytosphingosine (PS) on mite antigen-induced terminal differentiation abnormalities in HaCaT cells.
Gui Hyang Choi, Fazli Wahid, You Young Kim   +2 more
doaj   +1 more source