Results 81 to 90 of about 5,394 (197)

Self‐Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhengyi Zhang, Wenqian Du, Xiaojiang Zhang, Hongbo Cui, Baochen Cheng, Xiao Han, Ke He, Tingyi Yin, Xinyi Liu, Ningyi Xian, Ziyang Wang, Meng Liu, Dan Han, Jiankang Liu, Yan Zheng, Ya Wang   +15 more
wiley   +1 more source

Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo

Journal of Lipid Research, 2008
In an effort to find topical agents that prevent or retard cutaneous aging, seven functional lipids were screened for their procollagen-upregulating and matrix metalloproteinase (MMP)-1-downregulating activities in human dermal fibroblasts by Western ...
Soyun Cho, Hyeon Ho Kim, Min Jung Lee, Serah Lee, Chang-Seo Park, Sang-June Nam, Jeong-Jun Han, Jin-Wook Kim, Jin Ho Chung   +8 more
doaj   +1 more source

Stereoselective Transformation of Phytosphingosine to Safingol [PDF]

Bulletin of the Korean Chemical Society, 2009
A short and efficient synthesis of (2S,3S)-safingol from commercially available D-ribo-(2S,3S,4R)-phytosphingosine is described. The highlights of the synthesis are a stereoselective one-pot transformation of a diol into an epoxide under phase transfer catalytic conditions and a regioselective epoxide-opening reduction with a hydride reagent.
openaire   +1 more source

Nitration of GlcCer and Related Complex Lipids Enhances CD1d Binding Affinity and Modulates Immune Responses via Lipid Antigen Presentation to Natural Killer T Cells

ChemistryEurope, Volume 4, Issue 1, January 2026.
Nitration of glycolipids and phospholipids increases their binding to CD1d. Nitrated β‐GlcCer and phospholipids show strong CD1d binding but induce minimal cytokine production, suggesting potential immune suppression. In contrast, nitrated endogenous‐type α‐GalCer enhances cytokine responses, indicating that nitrated lipids can modulate CD1d‐mediated ...
Kodai Sueyoshi, Nanako Kawate‐Horiuchi, Kazunari Ueki, Risa Nozawa, Takanori Matsumaru, Yukari Fujimoto   +5 more
wiley   +1 more source

Biosynthesis of phytosphingosine by the rat.

Journal of Biological Chemistry, 1977
Labeled C18-phytosphingosine was detected in a glyco-lipid-rich fraction from rat intestine 4 and 24 h after injection of D-erythro[4,5-3H]C18-dihydrosphingosine. The criteria for identification were: (a) co-migration on gas-liquid chromatography of the trimethylsilyl ethers of the free and N-acetylated base with authentic standard, (b) co-migration on
M W, Crossman, C B, Hirschberg
openaire   +2 more sources

Synthesis of a Versatile Building Block for the Preparation of 6-N-Derivatized α-Galactosyl Ceramides: Rapid Access to Biologically Active Glycolipids [PDF]

, 2010
A concise route to the 6-azido-6-deoxy-α-galactosyl-phytosphingosine derivative 9 is reported. Orthogonal protection of the two amino groups allows elaboration of 9 into a range of 6-N-derivatized α-galactosyl ceramides by late-stage introduction of the ...
Besra, Gurdyal S., Cox, Liam R., Jervis, Peter J.   +2 more
core  

Molecular organization and in situ assembly of the human skin barrier [PDF]

, 2016
A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease.
Hollander, Lianne den
core   +1 more source

Bacillus simplex treatment promotes soybean defence against soybean cyst nematodes: A metabolomics study using GC-MS.

PLoS ONE, 2020
We aimed to profile the metabolism of soybean roots that were infected with soybean cyst nematodes and treated with Bacillus simplex to identify metabolic differences that may explain nematode resistance. Compared with control soybean roots, B.
Wen-Shu Kang, Li-Jie Chen, Yuan-Yuan Wang, Xiao-Feng Zhu, Xiao-Yu Liu, Hai-Yan Fan, Yu-Xi Duan   +6 more
doaj   +1 more source

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. [PDF]

, 2019
Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others ...
Adams, Alfadhel, Alfadhel, Alfadhel, Aljabri, Anwar, Aronson, Arts, Attwell, Baio, Banka, Barennes, Benton, Bettendorff, Bettendorff, Biesecker, Brown, Butterworth, Butterworth, Butterworth, Calhau, Carney, Chandrakumar, Chen, Cheung, Chornyy, Chugani, Colbert, Croft, Day, De Meirleir, Fattal-Valevski, Fattal-Valevski, Fleming, Forouhi, Foulon, Foulon, Fraccascia, Fraccascia, Fraser, Frustaci, Fujita, Galvin, Ganapathy, Gangolf, Ganie, Ghaleiha, Gibson, Giulivi, Gold, Greenwood, Gu, Harel, Hiffler, Hilker, Inaba, Ishaque, Israels, Jankowska-Kulawy, Junior, Kamasak, Karabatsiakis, Kelley, Kerns, Khaw, Kitamura, Kornreich, Kril, Laforenza, Leichter, Lindhurst, Liu, Lonsdale, Lonsdale, Lonsdale, Lorber, Lu, Lukienko, Luxemburger, Lương, Ma, Magos, Mahajan, Mahmood, Martel, Martin, Mayr, McLure, Mergenthaler, Mezzar, Mimouni-Bloch, Molina, Mulholland, Mulle, Muoio, Murata, Nabokina, Nabokina, Nardone, Navarro, Nikseresht, Obrenovich, Oishi, Opdenakker, Ortega Garcia, Ortigoza-Escobar, Pepersack, Perez-Duenas, Plaitakis, Prabakaran, Prohaska, Rabie, Randle, Renthal, Rindi, Rindi, Robinson, Roust, Rubio-Lopez, Said, Schaller, Scrimshaw, Sequeira Lopes da Silva, Shi, Singleton, Siu, Skjeldal, Smidt, Society, Song, Sperringer, Spiegel, Stargrove, Subramanian, Subramanian, Sweet, Tabarki, Talwar, Thomson, Thornalley, van den Brink, Vasconcelos, Vernau, Vernau, Vimokesant, Watkins, Wendel, Whitfield, Whitfield, Wierzbicki, Williams, Yang, Zhang, Zhao, Zuccoli   +154 more
core   +2 more sources

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen, Yuexuan Xu, Ying Xu, Xiao Liu, Yuting Zhang, Dan Ye, Sai Han, Shili Liu, Youzhong Zhang   +8 more
wiley   +1 more source