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Results 121 to 130 of about 662,858 (278)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source

Search for the B c + $$ {B}_c^{+} $$ → χ c1(3872)π + decay

Journal of High Energy Physics
A search for the decay B c + $$ {B}_c^{+} $$ → χ c1(3872)π + is reported using proton-proton collision data collected with the LHCb detector between 2011 and 2018 at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity ...
The LHCb collaboration +1148 more
doaj +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source

B -> pi, B(s) -> K form factors and Vub determination

, 2008
We present a QCD light-cone sum rule (LCSR) estimation of the B -> pi, B -> K, and Bs -> K form factors calculating gluon radiative corrections at next-to-leading order. The MS-bar b-quark mass is used, instead of the one-loop pole mass employed in the previous analyses.
openaire +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source

Polarization and quantum entanglement effects in $$B^\pm _c\rightarrow J/\psi +\pi ^\pm +\pi ^0$$ B c ± → J / ψ + π ± + π 0 process

European Physical Journal C: Particles and Fields
Motivated by the very recent observation of the $$B^+_c\rightarrow J/\psi +\pi ^+ +\pi ^0$$ B c + → J / ψ + π + + π 0 decay using proton–proton collision data by the LHCb collaboration, we study the four-body angular distributions and the quantum ...
Kaiwen Chen +4 more
doaj +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source

Measurement of the ratios of branching fractions B(B(s)(0)-> D(s)(-)pi(+))/B(B(0)-> D(-)pi(+)) and B(B(+)->(D)over-bar(0)pi(+))/B(B(0)-> D(-)pi(+))

, 2006
We report an observation of the decay B(s)(0)-> D(s)(-)pi(+) in p (p) over bar collisions at root s = 1.96 TeV using 115 pb(-1) of data collected by the CDF II detector at the Fermilab Tevatron. We observe 83 +/- 11(stat) B(s)(0)-> D(s)(-)pi(+) candidates, representing a large increase in statistics over previous measurements and the first ...
Abulencia, A +200 more
openaire +13 more sources

Measurement of the Ratios of Branching Fractions B(Bs->Ds- pi+)/B(B0->D-pi+) and B(B+->D0bar pi+)/B(B0->D-pi+)

, 2005
We report an observation of the decay Bs -> Ds- pi+ in p pbar collisions at sqrt(s) = 1.96 TeV using 115 pb^(-1) of data collected by the CDF II detector at the Fermilab Tevatron. We observe 83 +/- 11 Bs -> Ds- pi+ candidates, representing a large increase in statistics over previous measurements and the first observation of this decay at a p pbar ...
openaire +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source

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