Results 131 to 140 of about 662,858 (278)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The “ $$B\rightarrow K\pi $$ B → K π puzzle”: a new perspective

European Physical Journal C: Particles and Fields
A phenomenological analysis based on the published branching fractions and CP asymmetry observables of the $$B\rightarrow K\pi $$ B → K π , $$B\rightarrow \pi \pi $$ B → π π and $$B\rightarrow KK$$ B → K K dataset is performed.
Adam Szabelski
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Measurement of the ratio of branching fractions B(B(+/-) -> J/psi pi(+/-))/B(B(+/-) -> J/psi K(+/-)

, 2009
We report a measurement of the ratio of branching fractions of the decays B(+/-) -> J/psi pi(+/-) and B(+/-) -> J/psi K(+/-) using the CDF II detector at the Fermilab Tevatron Collider. The signal from the Cabbibo-suppressed B(+/-)-> J/psi pi(+/-) decay is separated from B(+/-) -> J/psi K(+/-) using the B(+/-)-> J/psi K(+/-) invariant ...
ABULENCIA A, ADELMAN J, AFFOLDER T, AKIMOTO T, ALBROW MG, AMBROSE D, AMERIO S, AMIDEI D, ANASTASSOV A, ANIKEEV K, ANNOVI A, ANTOS J, AOKI M, APOLLINARI G, ARGUIN JF, ARISAWA T, ARTIKOV A, ASHMANSKAS W, ATTAL A, AZFAR F, AZZI BACCHETTA P, AZZURRI P, BACCHETTA N, BADGETT W, BARBARO GALTIERI A, BARNES VE, BARNETT BA, BAROIANT S, BARTSCH V, BAUER G, BEDESCHI F, BEHARI S, BELFORTE S, BELLETTINI G, BELLINGER J, BELLONI A, BENJAMIN D, BERETVAS A, BERINGER J, BERRY T, BHATTI A, BINKLEY M, BISELLO D, BLAIR RE, BLOCKER C, BLUMENFELD B, BOCCI A, BODEK A, BOISVERT V, BOLLA G, BOLSHOV A, BORTOLETTO D, BOUDREAU J, BOVEIA A, BRAU B, BRIGLIADORI L, BROMBERG C, BRUBAKER E, BUDAGOV J, BUDD HS, BUDD S, BUDRONI S, BURKETT K, BUSETTO G, BUSSEY P, BYRUM KL, CABRERA S, CAMPANELLI M, CAMPBELL M, CANELLI F, CANEPA A, CARILLO S, CARLSMITH D, CAROSI R, CARRON S, CASARSA M, CASTRO A, CATASTINI P, CAUZ D, CAVALLI SFORZA M, CERRI A, CERRITO L, CHANG SH, CHEN YC, CHERTOK M, CHIARELLI G, CHLACHIDZE G, CHLEBANA F, CHO I, CHO K, CHOKHELI D, CHOU JP, CHOUDALAKIS G, CHUANG SH, CHUNG K, CHUNG WH, CHUNG YS, CILJAK M, CIOBANU CI, CIOCCI MA, CLARK A, CLARK D, COCA M, COMPOSTELLA G, CONVERY ME, CONWAY J, COOPER B, COPIC K, CORDELLI M, CORTIANA G, CRESCIOLI F, ALMENAR CC, CUEVAS J, CULBERTSON R, CULLY JC, CYR D, DARONCO S, DATTA M, D'AURIA S, DAVIES T, D'ONOFRIO M, DAGENHART D, DE BARBARO P, DE CECCO, Sandro, DEISHER A, DE LENTDECKER G, DELL'ORSO M, DELLI PAOLI F, DEMORTIER L, DENG J, DENINNO M, DE PEDIS D, DERWENT PF, DI GIOVANNI GP, DIONISI, Carlo, DI RUZZA B, DITTMANN JR, DITURO P, DORR C, DONATI S, DONEGA M, DONG P, DONINI J, DORIGO T, DUBE S, EFRON J, ERBACHER R, ERREDE D, ERREDE S, EUSEBI R, FANG HC, FARRINGTON S, FEDORKO I, FEDORKO WT, FEILD RG, FEINDT M, FERNANDEZ JP, FIELD R, FLANAGAN G, FOLAND A, FORRESTER S, FOSTER GW, FRANKLIN M, FREEMAN JC, FURIC I, GALLINARO M, GALYARDT J, GARCIA JE, GARBERSON F, GARFINKEL AF, GAY C, GERBERICH H, GERDES D, GIAGU, Stefano, GIANNETTI P, GIBSON A, GIBSON K, GIMMELL JL, GINSBURG C, GIOKARIS N, GIORDANI M, GIROMINI P, GIUNTA M, GIURGIU G, GLAGOLEV V, GLENZINSKI D, GOLD M, GOLDSCHMIDT N, GOLDSTEIN J, GOLOSSANOV A, GOMEZ G, GOMEZ CEBALLOS G, GONCHAROV M, MARGAROLI, Fabrizio, GORELOV I, GOSHAW AT, GOULIANOS K, GRESELE A, GRIFFITHS M, GRINSTEIN S, IORI, Maurizio, LATINO G, LOVERRE, Pier Ferruccio, MESSINA, Andrea   +203 more
openaire   +4 more sources

Measurement of the ratios of branching fractions B (B(s)(0)-> D(s)(-) pi(+) pi(+) pi(-))/B(B(0) -> D(-) pi(+) pi(+) pi(-)) and B(B(s)(0) -> D(s)(-) pi(+))/B(B(0)-> D(-) pi(+))

, 2007
Using 355 pb(-1) of data collected by the CDF II detector in p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron, we study the fully reconstructed hadronic decays B((s))(0) -> D((s))(-)pi(+) and B((s))(0) -> D((s))(-) pi(+)pi(+)pi(-).
Abulencia, A, Adelman, J, Affolder, T, Akimoto, T, Albrow, MG, Ambrose, D, Amerio, S, Amidei, D, Anastassov, A, Anikeev, K, Annovi, A, Antos, J, Aoki, M, Apollinari, G, Arguin, JF, Arisawa, T, Artikov, A, Ashmanskas, W, Attal, A, Azfar, F, Azzi-Bacchetta, P, Azzurri, P, Bacchetta, N, Badgett, W, Barbaro-Galtieri, A, Barnes, VE, Barnett, BA, Baroiant, S, Bartsch, V, Bauer, G, Bedeschi, F, Behari, S, Belforte, S, Bellettini, G, Bellinger, J, Belloni, A, Benjamin, D, Beretvas, A, Beringer, J, Berry, T, Bhatti, A, Binkley, M, Bisello, D, Blair, RE, Blocker, C, Blumenfeld, B, Bocci, A, Bodek, A, Boisvert, V, Bolla, G, Bolshov, A, Bortoletto, D, Boudreau, J, Boveia, A, Brau, B, Brigliadori, L, Bromberg, C, Brubaker, E, Budagov, J, Budd, HS, Budd, S, Budroni, S, Burkett, K, Busetto, G, Bussey, P, Byrum, KL, Cabrera, S, Campanelli, M, Campbell, M, Canelli, F, Canepa, A, Carillo, S, Carlsmith, D, Carosi, R, Casarsa, M, Castro, A, Catastini, P, Cauz, D, Cavalli-Sforza, M, Cerri, A, Cerrito, L, Chang, SH, Chen, YC, Chertok, M, Chiarelli, G, Chlachidze, G, Chlebana, F, Cho, I, Cho, K, Chokheli, D, Chou, JP, Choudalakis, G, Chuang, SH, Chung, K, Chung, WH, Chung, YS, Ciljak, M, Ciobanu, CI, Ciocci, MA, Clark, A, Clark, D, Coca, M, Compostella, G, Convery, ME, Conway, J, Cooper, B, Copic, K, Cordelli, M, Cortiana, G, Crescioli, F, Almenar, CC, Cuevas, J, Culbertson, R, Cully, JC, Cyr, D, DaRonco, S, D'Auria, S, Davies, T, D'Onofrio, M, Dagenhart, D, de Barbaro, P, De Cecco, S, Deisher, A, De Lentdecker, G, Dell'Orso, M, Paoli, FD, Demortier, L, Deng, J, Deninno, M, De Pedis, D, Derwent, PF, Di Giovanni, GP, Dionisi, C, Di Ruzza, B, Dittmann, JR, DiTuro, P, Dorr, C, Donati, S, Donega, M, Dong, P, Donini, J, Dorigo, T, Dube, S, Efron, J, Erbacher, R, Errede, D, Errede, S, Eusebi, R, Fang, HC, Farrington, S, Fedorko, I, Fedorko, WT, Feild, RG, Feindt, M, Fernandez, JP, Field, R, Flanagan, G, Foland, A, Forrester, S, Foster, GW, Franklin, M, Freeman, JC, Furic, I, Gallinaro, M, Galyardt, J, Garcia, JE, Garberson, F, Garfinkel, AF, Gay, C, Gerberich, H, Gerdes, D, Giagu, S, Giannetti, P, Gibson, A, Gibson, K, Gimmell, JL, Ginsburg, C, Giokaris, N, Giordani, M, Giromini, P, Giunta, M, Giurgiu, G, Glagolev, V, Glenzinski, D, Gold, M, Goldschmidt, N, Goldstein, J, Gomez, G, Gomez-Ceballos, G, Goncharov, M, Gonzalez, O, Gorelov, I, Goshaw, AT, Goulianos, K, Gresele, A, Griffiths, M, Grinstein, S, Grosso-Pilcher, C, Group, RC, Grundler, U, Latino, G   +200 more
openaire   +13 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

CP-violating observables of four-body $$B_{(s)} \rightarrow (\pi \pi )(K\bar{K})$$ B ( s ) → ( π π ) ( K K ¯ ) decays in perturbative QCD

European Physical Journal C: Particles and Fields
In this work, we investigate six helicity amplitudes of the four-body $$B_{(s)} \rightarrow (\pi \pi )(K\bar{K})$$ B ( s ) → ( π π ) ( K K ¯ ) decays via an angular analysis in the perturbative QCD (PQCD) approach.
Da-Cheng Yan, Yan Yan, Zhou Rui
doaj   +1 more source