Results 121 to 130 of about 59,033 (267)
Trends and Variation in End-of-Life Care for Medicare Beneficiaries With Severe Chronic Illness [PDF]
, 2011 Provides an updated analysis of regional and hospital variations in end-of-life care for Medicare beneficiaries with chronic illnesses, including percentage of hospital deaths, days in intensive care units, and physician labor per ...
Amos R. Esty +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
BioengineeringIn this comprehensive study, we delve into the intricate binding properties of tannic acid (TA) and examine their dual role in the realm of biomaterial development. While TA’s properties can enhance the functionality and performance of biomaterials, they
Silvia Cometta, Dietmar Werner Hutmacher
doaj +1 more source
Literatura y LingüísticaEste trabajo analiza la traducción de términos del ámbito jurídico chileno al mapuzugun, lengua indígena con mayor número de hablantes en el estado de Chile. En particular, examina las técnicas de traducción de 75 términos jurídicos, extraídos de 30 textos bilingües español-mapuzugun, con el doble objetivo de examinar en qué medida la traducción de un ...
Belén Villena Araya +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Solution to a semilinear problem on type II regions determined by the Fucik spectrum
Electronic Journal of Differential Equations, 2003 We prove the existence of solutions to the semi-linear problem $$displaylines{ u''(x)+alpha u^+(x)+ta u^-(x)=f(x),,quad xin (0,pi),,cr u(0)=u(pi)=0 } $$ where the point $(alpha,eta)$ falls in regions of type (II) between curves of the Fucik spectrum.
Petr Tomiczek
doaj
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Replica-deformation of the SU(2)-invariant Thirring model via solutions of the qKZ equation
, 1999 The response of an integrable QFT under variation of the Unruh temperature has recently been shown to be computable from an S-matrix preserving (`replica') deformation of the form factor approach.
't Hooft +25 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source