Results 251 to 260 of about 532,120 (306)
Metformin hydrochloride regulates glycolysis and inhibits PEDV replication by inhibition of PI3K-AKT signaling pathway. [PDF]
J VirolZhang X +12 more
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ZNF460 inhibits HMGCL and promotes PI3K pathway in colon cancer. [PDF]
Transl Cancer ResHou W +8 more
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2022
Highly conserved from yeast to mammals, vacuolar protein sorting 34 (Vps34) is the sole member of the third class of the phosphoinositide 3-kinase (PI3K) family. By producing phosphatidylinositol-3-monophosphate (PtdIns3P) through its scaffolding function essential for the catalytic lipid activity, Vps34 regulates endosomal trafficking, autophagy ...
Manuella, Caux +2 more
openaire +2 more sources
Highly conserved from yeast to mammals, vacuolar protein sorting 34 (Vps34) is the sole member of the third class of the phosphoinositide 3-kinase (PI3K) family. By producing phosphatidylinositol-3-monophosphate (PtdIns3P) through its scaffolding function essential for the catalytic lipid activity, Vps34 regulates endosomal trafficking, autophagy ...
Manuella, Caux +2 more
openaire +2 more sources
2022
This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains, domain-domain interactions, and functional relevance.
Tihitina Y, Aytenfisu +4 more
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This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains, domain-domain interactions, and functional relevance.
Tihitina Y, Aytenfisu +4 more
openaire +2 more sources
PI3Ks in Diabetic Cardiomyopathy
Journal of Cardiovascular Pharmacology, 2017Abstract:Diabetic cardiomyopathy is a heart disease in diabetic patients, identified as ventricular dysfunction in the absence of coronary artery disease and hypertension. The molecular mechanisms underlying diabetic cardiomyopathy are still poorly understood.
Li, MC, Murabito, A, Ghigo, A, Hirsch, E
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Science's STKE, 2007
Class I phosphoinositide 3-kinases (PI3Ks) are well-established signal transduction enzymes that play an important role in the mechanisms by which a wide variety of cell surface receptors control several cellular functions, including cellular growth, division, survival, and movement.
Simon, Andrews +2 more
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Class I phosphoinositide 3-kinases (PI3Ks) are well-established signal transduction enzymes that play an important role in the mechanisms by which a wide variety of cell surface receptors control several cellular functions, including cellular growth, division, survival, and movement.
Simon, Andrews +2 more
openaire +2 more sources
Targeting PI3K in neuroblastoma
Journal of Cancer Research and Clinical Oncology, 2010This work employs pharmacological targeting of phosphoinositide 3-kinases (PI3K) in selected neuroblastoma (NB) tumors with the inhibitor AS605240, which has been shown to express low toxicity and relative specificity for the PI3K species γ.The expression pattern of PI3K isoforms in 7 NB cell lines and 14 tumor patient samples was determined by Western
Spitzenberg, Volker +11 more
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PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2018The phosphoinositide 3-kinase (PI3K) pathway integrates multifarious environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the PI3K pathway increases biological fitness by offering a high degree of adaptability to and resilience against diverse perturbations, thus conferring survival benefits on premalignant and ...
Soonbum, Park +4 more
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