Results 251 to 260 of about 390,020 (313)

MT1G promotes the progression of ccRCC by suppressing ferroptosis through activation of the PI3K-AKT pathway. [PDF]

Transl Oncol
Zhang L, Sun J, Ma Y, Yan F, Huang Z.
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Plumbagin Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR-Mediated Pathway in Human Pancreatic Cancer Cells [Retraction]. [PDF]

Drug Des Devel Ther
europepmc   +1 more source

Mechanism Through Which Antioxidant Polysaccharide from <i>Tetrastigma hemsleyanum</i> Protects Against DSS-Induced Ulcerative Colitis: Insights from Multi-Omics. [PDF]

Molecules
Zhang L, Xu W, Liao X, Yuan G, Jin C, Xiao H, Liu H, Jin Z, Deng Y, Liu Y.   +9 more
europepmc   +1 more source

Astragaloside IV attenuates high-glucose-Induced peritoneal fibrosis via modulation of the ENKUR/PI3K/Akt signalling pathway. [PDF]

PLoS One
Jiang T, Zhang L, Liu J, Xu X, Shi Y, Zhao Z, Xiao J.   +6 more
europepmc   +1 more source

Novel PI3K and mTOR selective inhibitors to deconvolute PI3K signaling

, 2021
Phosphoinositide 3-kinase (PI3K) signaling has key roles in the regulation of cellular processes such as cell growth, proliferation, and metabolism. Constitutive activation of PI3K in tumors is frequent and drives cancer progression. Considering the contribution of aberrant PI3K signaling in cancer progression, pharmacological intervention strategies ...
Keles, Erhan
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PI3Ks in Diabetic Cardiomyopathy

Journal of Cardiovascular Pharmacology, 2017
Abstract:Diabetic cardiomyopathy is a heart disease in diabetic patients, identified as ventricular dysfunction in the absence of coronary artery disease and hypertension. The molecular mechanisms underlying diabetic cardiomyopathy are still poorly understood.
Mingchuan, Li, Alessandra, Murabito, Alessandra, Ghigo, Emilio, Hirsch   +3 more
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Targeting PI3K in neuroblastoma

Journal of Cancer Research and Clinical Oncology, 2010
This work employs pharmacological targeting of phosphoinositide 3-kinases (PI3K) in selected neuroblastoma (NB) tumors with the inhibitor AS605240, which has been shown to express low toxicity and relative specificity for the PI3K species γ.The expression pattern of PI3K isoforms in 7 NB cell lines and 14 tumor patient samples was determined by Western
Spitzenberg, Volker, König, Christian, Ulm, Susanne, Marone, Romina, Röpke, Luise, Müller, Jörg P., Grün, Michael, Bauer, Reinhard, Rubio, Ignacio, Wymann, Matthias Paul, Voigt, Astrid, Wetzker, Reinhard   +11 more
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PI3K Signaling in Neutrophils

2010
PI3Ks play important roles in the signaling pathways used by a wide variety of cell surface receptors on neutrophils. Class IB PI3K plays a major role in the initial generation of PtdIns(3,4,5)P₃ by Gi-coupled G-protein coupled receptors (GPCRs) (e.g., receptors for fMLP, C5a, LTB₄). Class IA PI3Ks generate PtdIns(3,4,5)P₃ downstream of receptors which
Phillip T, Hawkins, Len R, Stephens, Sabine, Suire, Michael, Wilson   +3 more
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PI3K pathway in prostate cancer: All resistant roads lead to PI3K

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2018
The phosphoinositide 3-kinase (PI3K) pathway integrates multifarious environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the PI3K pathway increases biological fitness by offering a high degree of adaptability to and resilience against diverse perturbations, thus conferring survival benefits on premalignant and ...
Soonbum, Park, Young Sik, Kim, Davis Yeon, Kim, Insuk, So, Ju-Hong, Jeon   +4 more
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