Results 261 to 270 of about 390,020 (313)
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PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms
Advances in Biological Regulation, 2015Cardiovascular diseases are the most common cause of death around the world. This includes atherosclerosis and the adverse effects of its treatment, such as restenosis and thrombotic complications. The development of these arterial pathologies requires a series of highly-intertwined interactions between immune and arterial cells, leading to specific ...
Adrien, Lupieri +4 more
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2022
Phosphatidylinositol-3-kinases (PI3K) control many aspects of cellular activation and differentiation and play an important role in B cells biology. Three different classes of PI3K have been described, all of which are expressed in B cells. However, it is the class IA PI3Ks, and the p110δ catalytic subunit in particular, which seem to play the most ...
Elissa K, Deenick +2 more
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Phosphatidylinositol-3-kinases (PI3K) control many aspects of cellular activation and differentiation and play an important role in B cells biology. Three different classes of PI3K have been described, all of which are expressed in B cells. However, it is the class IA PI3Ks, and the p110δ catalytic subunit in particular, which seem to play the most ...
Elissa K, Deenick +2 more
openaire +2 more sources
LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family
Bioorganic & Medicinal Chemistry Letters, 2001Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family.
G, Chiosis, N, Rosen, L, Sepp-Lorenzino
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2022
This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains, domain-domain interactions, and functional relevance.
Tihitina Y, Aytenfisu +4 more
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This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains, domain-domain interactions, and functional relevance.
Tihitina Y, Aytenfisu +4 more
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Journal of Pediatric Hematology/Oncology, 2015
Neuroblastoma is the most common extracranial cancer in childhood. High-risk neuroblastoma continues to have a poor prognosis and there is an urgent need to design biologically based therapies that specifically target the pathways responsible for malignant transformation and progression. One such pathway is the PI3K/Akt/mTOR pathway. In this article we
David, King +2 more
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Neuroblastoma is the most common extracranial cancer in childhood. High-risk neuroblastoma continues to have a poor prognosis and there is an urgent need to design biologically based therapies that specifically target the pathways responsible for malignant transformation and progression. One such pathway is the PI3K/Akt/mTOR pathway. In this article we
David, King +2 more
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Science Signaling, 2008
Immunoglobulin E (IgE) triggers the activation of the FcεRI immune receptor, which signals through immunoreceptor-based tyrosine activation motifs, in response to allergens. FcεRI activation on mast cells produces an increase in intracellular calcium concentration, which causes degranulation and the release of inflammatory mediators such ...
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Immunoglobulin E (IgE) triggers the activation of the FcεRI immune receptor, which signals through immunoreceptor-based tyrosine activation motifs, in response to allergens. FcεRI activation on mast cells produces an increase in intracellular calcium concentration, which causes degranulation and the release of inflammatory mediators such ...
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2022
Introduction BCR-ABL1-negative classic myeloproliferative neoplasms (MPN) include primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Calreticulin (CALR) 52 bp deletion and 5 bp insertion were discovered to be involved in MPN pathogenesis.
Vadeikienė, Roberta +4 more
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Introduction BCR-ABL1-negative classic myeloproliferative neoplasms (MPN) include primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Calreticulin (CALR) 52 bp deletion and 5 bp insertion were discovered to be involved in MPN pathogenesis.
Vadeikienė, Roberta +4 more
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Biochemical Society Transactions, 2007
Class IA PI3Ks (phosphoinositide 3-kinases) regulate a wide range of cellular responses through the production of PI(3,4,5)P3 (phosphatidylinositol 3,4,5-trisphosphate) in cellular membranes. They are activated by receptor tyrosine kinases, by Ras and Rho family GTPases, and in some cases by Gβγ subunits from trimeric G-proteins.
H, Wu, Y, Yan, J M, Backer
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Class IA PI3Ks (phosphoinositide 3-kinases) regulate a wide range of cellular responses through the production of PI(3,4,5)P3 (phosphatidylinositol 3,4,5-trisphosphate) in cellular membranes. They are activated by receptor tyrosine kinases, by Ras and Rho family GTPases, and in some cases by Gβγ subunits from trimeric G-proteins.
H, Wu, Y, Yan, J M, Backer
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Chemically targeting the PI3K family
Biochemical Society Transactions, 2007PI3K (phosphoinositide 3-kinase) is a key regulator of cell growth, metabolism and survival. The frequent activation of the PI3K pathway in cancer has stimulated widespread interest in identifying potent and selective inhibitors of PI3K isoforms. The present paper highlights recent progress in identifying such molecules and the challenges that remain ...
Z A, Knight, K M, Shokat
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PI3K and Chemotaxis: A Priming Issue?
Science Signaling, 2011The differentiation or “priming” status of cells may explain contradictory findings for the role of phosphoinositide 3-kinases in chemotaxis.
Philippe V, Afonso, Carole A, Parent
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