Results 261 to 270 of about 532,120 (306)
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Gan to kagaku ryoho. Cancer & chemotherapy, 2011
PI3K-Akt is an important signal transduction pathway which acts downstream from various growth factor receptors. The PI3K-Akt pathway is activated in many types of cancers by several mechanisms, including growth factor receptor activation, loss of PTEN, and PI3K gene mutations. Therefore, PI3K is thought to be an ideal therapeutic target.
Seiji, Yano +6 more
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PI3K-Akt is an important signal transduction pathway which acts downstream from various growth factor receptors. The PI3K-Akt pathway is activated in many types of cancers by several mechanisms, including growth factor receptor activation, loss of PTEN, and PI3K gene mutations. Therefore, PI3K is thought to be an ideal therapeutic target.
Seiji, Yano +6 more
openaire +1 more source
2010
PI3Ks play important roles in the signaling pathways used by a wide variety of cell surface receptors on neutrophils. Class IB PI3K plays a major role in the initial generation of PtdIns(3,4,5)P₃ by Gi-coupled G-protein coupled receptors (GPCRs) (e.g., receptors for fMLP, C5a, LTB₄). Class IA PI3Ks generate PtdIns(3,4,5)P₃ downstream of receptors which
Phillip T, Hawkins +3 more
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PI3Ks play important roles in the signaling pathways used by a wide variety of cell surface receptors on neutrophils. Class IB PI3K plays a major role in the initial generation of PtdIns(3,4,5)P₃ by Gi-coupled G-protein coupled receptors (GPCRs) (e.g., receptors for fMLP, C5a, LTB₄). Class IA PI3Ks generate PtdIns(3,4,5)P₃ downstream of receptors which
Phillip T, Hawkins +3 more
openaire +2 more sources
Science, 2007
Structural information about an enzyme implicated in numerous cancers provides insights into to how certain mutations promote cancer cell growth and survival.
Jennifer Y. Lee +2 more
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Structural information about an enzyme implicated in numerous cancers provides insights into to how certain mutations promote cancer cell growth and survival.
Jennifer Y. Lee +2 more
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PI3K Inhibitor–Induced Insulin Feedback Activates PI3K Signaling
Cancer Discovery, 2018Abstract Hyperinsulinemia drives resistance to PI3Kα inhibitors in tumors.
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Science Signaling, 2012
During the starvation response, the IκB kinase IKK phosphorylates the regulatory subunit of PI3K, thus inhibiting PI3K activity.
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During the starvation response, the IκB kinase IKK phosphorylates the regulatory subunit of PI3K, thus inhibiting PI3K activity.
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PI3K inhibitors are finally coming of age
Nature Reviews Drug Discovery, 2021Bart Vanhaesebroeck +2 more
exaly
PI3K and cancer: lessons, challenges and opportunities
Nature Reviews Drug Discovery, 2014David A Fruman
exaly