Results 291 to 300 of about 626,720 (343)
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Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Nature Reviews Cancer, 2009J. Engelman
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Targeting the PI3K pathway in cancer: are we making headway?
Nature Reviews Clinical Oncology, 2018Filip Janku, Funda Meric-Bernstam
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PI3K isoforms in cell signalling and vesicle trafficking
Nature Reviews Molecular Cell Biology, 2019, York Posor
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Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
Nature Reviews Drug Discovery, 2005Bryan T Hennessy +2 more
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The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
Biotechnology and applied biochemistry, 2021Autophagy causes the breakdown of damaged proteins and organelles to their constituent components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in regulating the autophagic response of cells in response to changing reactive ...
Dr Lakhan Kma, Dr Taranga Jyoti Baruah
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The emerging mechanisms of isoform-specific PI3K signalling
Nature Reviews Molecular Cell Biology, 2010+2 more
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2022
Highly conserved from yeast to mammals, vacuolar protein sorting 34 (Vps34) is the sole member of the third class of the phosphoinositide 3-kinase (PI3K) family. By producing phosphatidylinositol-3-monophosphate (PtdIns3P) through its scaffolding function essential for the catalytic lipid activity, Vps34 regulates endosomal trafficking, autophagy ...
Manuella, Caux +2 more
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Highly conserved from yeast to mammals, vacuolar protein sorting 34 (Vps34) is the sole member of the third class of the phosphoinositide 3-kinase (PI3K) family. By producing phosphatidylinositol-3-monophosphate (PtdIns3P) through its scaffolding function essential for the catalytic lipid activity, Vps34 regulates endosomal trafficking, autophagy ...
Manuella, Caux +2 more
openaire +2 more sources
2022
This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains, domain-domain interactions, and functional relevance.
Tihitina Y, Aytenfisu +4 more
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This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains, domain-domain interactions, and functional relevance.
Tihitina Y, Aytenfisu +4 more
openaire +2 more sources
PI3Ks in Diabetic Cardiomyopathy
Journal of Cardiovascular Pharmacology, 2017Abstract:Diabetic cardiomyopathy is a heart disease in diabetic patients, identified as ventricular dysfunction in the absence of coronary artery disease and hypertension. The molecular mechanisms underlying diabetic cardiomyopathy are still poorly understood.
Li, MC, Murabito, A, Ghigo, A, Hirsch, E
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Science's STKE, 2007
Class I phosphoinositide 3-kinases (PI3Ks) are well-established signal transduction enzymes that play an important role in the mechanisms by which a wide variety of cell surface receptors control several cellular functions, including cellular growth, division, survival, and movement.
Simon, Andrews +2 more
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Class I phosphoinositide 3-kinases (PI3Ks) are well-established signal transduction enzymes that play an important role in the mechanisms by which a wide variety of cell surface receptors control several cellular functions, including cellular growth, division, survival, and movement.
Simon, Andrews +2 more
openaire +2 more sources