Results 91 to 100 of about 64,413 (204)
Journal of Pharmacological Sciences, 2015 The human ether-a-go-go-related gene (HERG) potassium current (IHERG) has been shown to decrease in amplitude following stimulation with Gq protein-coupled receptors (GqRs), such as α1-adrenergic and M1-muscarinic receptors (α1R and M1R, respectively ...
Taeko Kubo +5 more
doaj +1 more source
A phosphatidylinositol (4,5)-bisphosphate binding site within μ2-adaptin regulates clathrin-mediated endocytosis [PDF]
, 2002 The clathrin adaptor complex AP-2 serves to coordinate clathrin-coated pit assembly with the sorting of transmembrane cargo proteins at the plasmalemma.
Haucke, Volker +2 more
core +2 more sources
Advanced Science, EarlyView.Sensorized fingertips are needed to unlock robotic dexterity, versatility, and diverse interactions. Here, 15 identically‐shaped robotic fingertips are benchmarked by a fully automated toolchange system, covering eight different materials and six broadly‐ranging sensing mechanisms.
David Hardman +5 more
wiley +1 more source
Multivalent Cation-Bridged PI(4,5)P2 Clusters Form at Very Low Concentrations [PDF]
Biophysical Journal, 2018 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2), is a key component of the inner leaflet of the plasma membrane in eukaryotic cells. In model membranes, PIP2 has been reported to form clusters, but whether these locally different conditions could give rise to distinct pools of unclustered and clustered PIP2 is unclear.
Yi, Wen +2 more
openaire +2 more sources
Kinetics of PTEN-mediated PI(3,4,5)P3 hydrolysis on solid supported membranes. [PDF]
PLoS ONE, 2018 Phosphatidylinositides play important roles in cellular signaling and migration. Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an important phosphatidylinositide because it acts as a secondary messenger to trigger cell movement and ...
Chun Liu +4 more
doaj +1 more source
The Distribution of Phosphatidylinositol 4,5-Bisphosphate in Acinar Cells of Rat Pancreas Revealed with the Freeze-Fracture Replica Labeling Method [PDF]
, 2011 Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is a phospholipid that has been implicated in multiple cellular activities. The distribution of PI(4,5)P2 has been analyzed extensively using live imaging of the GFP-coupled phospholipase C-δ1 pleckstrin ...
A Fujita +44 more
core +3 more sources
Advanced Science, EarlyView.Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider +20 more
wiley +1 more source
Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A
Nature Communications, 2023 Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays important cellular regulatory roles, including activation and inhibition of ion channels. The structural basis of ion channel regulation by LC-CoA is not known.
Bo-Hyun Lee +3 more
doaj +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site [PDF]
, 2002 Background: Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P-2).
Ampe, Christophe +4 more
core +3 more sources