Results 101 to 110 of about 707,375 (141)

Tuning of Plasma Membrane PI(4,5)P2 Charge Regulates Cell Migration and Glycolysis

, 2020
Directional cell migration, chemotaxis, requires a polarized cell morphology in which the cell extends pseudopodia at the front and contracts the rear to move towards a stimulus. PI(4,5)P2 levels set up a threshold for the activity of signaling molecules
Bawazir, Nada Sami
core  

Pi(4,5)P2 Modulates Hysteresis and Pharmacology of KV7 Channels

, 2017
KV7 channels are critical components of the plasma membrane in many excitable cells. The main function of KV7 channels is to contribute to the maintenance of the resting potential, thus regulating cellular electrical excitability.
Carlos A. Villalba-Galea, Villalba-Galea, Carlos A.   +1 more
core   +1 more source

PI(4,5)P2: signaling the plasma membrane. [PDF]

Biochem J, 2022
Wills RC, Hammond GRV.
europepmc   +1 more source

Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved.

, 2017
Inositol polyphosphate 5-phosphatases or phosphoinositide 5-phosphatases (PI 5-phosphatases) are enzymes that can act on soluble inositol phosphates and/or phosphoinositides (PIs).
Christophe Erneux, Elong Edimo, William's, Ramos, Ana Raquel, Ana Raquel Ramos, William's Elong Edimo, Erneux, Christophe   +5 more
core   +1 more source

PIP5Kγ Mediates PI(4,5)P2/Merlin/LATS1 Signaling Activation and Interplays with Hsc70 in Hippo-YAP Pathway Regulation. [PDF]

Int J Mol Sci, 2023
Le DDT, Le TPH, Lee SY.
europepmc   +1 more source

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2 [PDF]

Mutations in the ankyrin repeat domain (ARD) of ?TRPV4 are responsible for several channelopathies, including Charcot?Marie?Tooth disease type 2C and congenital distal and scapuloperoneal spinal muscular atrophy.
Takahashi, Nobuaki, Itoh, Yuzuru, Kohda, Daisuke, Shimada, Atsushi, Matsuoka, Rei, Kiyonaka, Shigeki, Hamada-Nakahara, Sayaka, Takemura, Kazuhiro, Hanawa-Suetsugu, Kyoko, Mori, Yasuo, Kitamata, Manabu, Mori, Masayuki X., Ueda, Yoshifumi, Kitao, Akio, Suetsugu, Shiro, Senju, Yosuke   +15 more
core   +1 more source

LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex

iScience
Summary: Phosphatidylinositol (PI) is highly enriched in arachidonic acid, an essential polyunsaturated fatty acid for brain development. This enrichment is mediated by the phospholipid remodeling enzyme lysophospholipid acyltransferase 11 (LPLAT11 ...
Yuki Ishino, Yusuke Kishi, Taiga Iwama, Naohiro Kuwayama, Hiroyuki Arai, Yukiko Gotoh, Junken Aoki, Nozomu Kono   +7 more
doaj   +1 more source

Étude des voies de signalisation qui régulent l’homéostasie du PI(4,5)P2 [PDF]

, 2017
Diverses mutations de l’inositol 5-phosphatase OCRL (OcculoCerebroRenal Lowe), empêchant la catalyse de la conversion du phosphatidylinositol 4,5-biphosphate [PI(4,5)P2] en phosphatidylinositol 4 phosphate [PI(4)P], sont la cause du syndrome de Lowe ...
Babouder, Maïssa
core  

Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2. [PDF]

J Cell Biol, 2022
Lolicato F, Saleppico R, Griffo A, Meyer A, Scollo F, Pokrandt B, Müller HM, Ewers H, Hähl H, Fleury JB, Seemann R, Hof M, Brügger B, Jacobs K, Vattulainen I, Nickel W.   +15 more
europepmc   +1 more source

PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. [PDF]

Cell Mol Life Sci, 2022
Gass MM, Borkowsky S, Lotz ML, Siwek R, Schröter R, Nedvetsky P, Luschnig S, Rohlmann A, Missler M, Krahn MP.   +9 more
europepmc   +1 more source