Results 101 to 110 of about 62,994 (190)
JSFA reports, EarlyView.Abstract Background Lafun is made by fermenting and drying cassava chunks, which are then milled into flour and cooked into dough. Its quality characteristics are variety‐dependent, while it may become too soft or even liquefy during storage, leading to rejection by end‐users.
Laurent Adinsi +6 more
wiley +1 more source
Quantitative Analysis of Binding Affinities of PI(4,5)P2 Sensor Domains in Living Cells by Using the Voltage-Controlled PI(4,5)P2-5’-Phosphatase, Ci-VSP [PDF]
Biophysical Journal, 2010 Dynamic changes in the phosphoinositide (PI) concentration in the cell membrane play an important role in the regulation of many cellular processes. Of particular interest is the PI phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a genuine signaling molecule that, e.g., controls the function of some ion channels.Plasma membrane PI concentration in ...
Halaszovich, Christian R. +2 more
openaire +1 more source
Kinetics of PTEN-mediated PI(3,4,5)P3 hydrolysis on solid supported membranes. [PDF]
PLoS ONE, 2018 Phosphatidylinositides play important roles in cellular signaling and migration. Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an important phosphatidylinositide because it acts as a secondary messenger to trigger cell movement and ...
Chun Liu +4 more
doaj +1 more source
HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly [PDF]
, 2019 HIV-1 Gag protein assembles at the plasma membrane of infected cells for viral particle formation. Gag targets lipids, mainly PI(4,5)P2, at the inner leaflet of this membrane.
Chojnacki, Jakub +6 more
core +1 more source
Influence of crosslinker on the properties of terpene‐based poly(high internal phase emulsion)s
Polymer International, EarlyView.Myrcene was polymerized and crosslinked with hydrophilic monomeric and oligomeric dimethacrylates within high internal phase emulsions to produce hierarchically porous bio‐based poly(high internal phase emulsion)s with tuned morphology and mechanical properties.
Rumeysa Beyaz +5 more
wiley +1 more source
Rational Design and Development of Organic Afterglow Nanoparticles for Image‐Guided Interventions
Small Methods, EarlyView.This review outlines the rational design, synthesis, and standardized characterization of organic afterglow nanoparticles for biomedical imaging and therapy. Mechanistic insights into chemically initiated electron exchange luminescence and reactive oxygen species‐mediated processes are connected to molecular engineering and nanoparticle fabrication ...
Asma Harun +6 more
wiley +1 more source
Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies
JCI Insight, 2022 Ciliopathies are a class of genetic diseases resulting in cilia dysfunction in multiple organ systems, including the olfactory system. Currently, there are no available curative treatments for olfactory dysfunction and other symptoms in ciliopathies. The
Chao Xie +6 more
doaj +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila
Cell Reports, 2015 Cilia are highly specialized antennae-like cellular organelles. Inositol polyphosphate 5-phosphatase E (INPP5E) converts PI(4,5)P2 into PI4P and is required for proper ciliary function. Although Inpp5e mutations are associated with ciliopathies in humans
Jina Park +5 more
doaj +1 more source
Clinical Endocrinology, EarlyView.ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore +6 more
wiley +1 more source