, 2011 Zusammenfassung Quantifizierung der in-vivo Affinität von PI(4,5)P2- Effektoren und Sensoren mit der Phosphoinositidphosphatase Ci-VSP Phosphoinositide (PI) sind Mitglieder einer Familie kleiner Membranphospholipide, die wichtige Aufgaben in vielen ...
Rjasanow, Alexandra
core +2 more sources
Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2
Nature Communications, 2019 Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P2/PI(3,4)P2 allosterically enhances ORP1-mediated cholesterol exit from ...
Jiangqing Dong +11 more
doaj +1 more source
Insights into the molecular recognition of the granuphilin C2A domain with PI(4,5)P2
, 2015 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a key player in regulating the process of excytosis, including insulin secretion. Granuphilin, a tandem C2 domain containing protein, mediates the docking of insulin granules onto plasma membrane.
Shi, Yunyu +9 more
core +1 more source
Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission [PDF]
, 2011 SummaryPhosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] plays a fundamental role in clathrin-mediated endocytosis. However, precisely how PI(4,5)P2 metabolism is spatially and temporally regulated during membrane internalization and the functional ...
Belle Chang-Ileto +11 more
core +1 more source
Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer
Lipids in Health and DiseaseThe development of metastasis is a leading cause of cancer-related death that involves specific changes in the plasma membrane (PM) and nucleus of cancer cells.
Agnieszka Chytła +3 more
doaj +1 more source
A Pil1–Sle1–Syj1–Tax4 Functional Pathway Links Eisosomes with PI(4,5)P2 Regulation [PDF]
, 2013 Stable compartments of the plasma membrane promote a wide range of cellular functions. In yeast cells, cytosolic structures called eisosomes generate prominent cortical invaginations of unknown function.
Moseley, James B +3 more
core +1 more source
Rôles et régulation du PI(4,5)P2 dans le remodelage cortical et la morphogénèse cellulaire en mitose [PDF]
, 2011 La division cellulaire doit être précisément contrôlée dans le temps et dans l'espace pour permettre la formation de deux cellules filles, au contenu génétique identique à celui de la cellule mère.
Roubinet, Chantal
core
Impact of calcium on PI(4,5)P2: protein interactions and membrane organization
, 2017 Tese de mestrado em Bioquímica, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2017PI(4,5)P2 é um importante fosfoinositol, localizado no folheto interno das células eucariotas, que possui um grupo inositol hidrófilo, carregado ...
Araújo, Luís Pedro Borges
core +3 more sources
The Dysferlin C2A Domain Binds PI(4,5)P2 and Penetrates Membranes. [PDF]
J Mol Biol, 2023 Kwok E +11 more
europepmc +1 more source
PI(4,5)P2 regulates the gating of NaV1.4 channels. [PDF]
J Gen Physiol, 2023 Gada KD +5 more
europepmc +1 more source