Results 101 to 110 of about 64,413 (204)
Advanced Science, EarlyView.The prevailing neglect of cellular hierarchies in current spatial transcriptomics deconvolution often obscures cellular heterogeneity and impedes the identification of fine‐grained subtypes. To address this issue, HIDF employs a cluster‐tree and dual regularization to systematically model cellular hierarchical structures.
Zhiyi Zou +5 more
wiley +1 more source
Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies
JCI Insight, 2022 Ciliopathies are a class of genetic diseases resulting in cilia dysfunction in multiple organ systems, including the olfactory system. Currently, there are no available curative treatments for olfactory dysfunction and other symptoms in ciliopathies. The
Chao Xie +6 more
doaj +1 more source
Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion [PDF]
Phosphatidylinositol 4,5-bisphosphate (PI 4,5-P2) on the plasma membrane is essential for vesicle exocytosis but its role in membrane fusion has not been determined.
James, Declan J. +3 more
core +2 more sources
Interface Engineering Strategies for Realizing Anode‐Free Sodium Batteries: A Review
Advanced Energy Materials, EarlyView.This review examines anode‐free sodium batteries as a promising solution for advancing sodium‐based energy storage. It focuses on the role of interface engineering in addressing challenges such as sodium deposition, interface stability, and dendrite growth.
Yulian Dong +6 more
wiley +1 more source
Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes [PDF]
, 2002 Phospholipase D (PLD) generates lipid signals that coordinate membrane trafficking with cellular signaling. PLD activity in vitro and in vivo is dependent on phosphoinositides with a vicinal 4,5-phosphate pair.
Engebrecht, JoAnne +5 more
core +3 more sources
Advanced Energy Materials, EarlyView.A dual lattice‐surface strategy employing NaTi2(PO4)3 is adopted to enhance the performance of P3‐type Na0.67[Zn0.3Mn0.7]O2, whereby Ti stabilizes the bulk lattice and surface P species mitigate degradation, collectively improving high‐voltage cycling stability, Na+ diffusion, and oxygen redox reversibility through synergistic structural and ...
Natalia Voronina +13 more
wiley +1 more source
Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila
Cell Reports, 2015 Cilia are highly specialized antennae-like cellular organelles. Inositol polyphosphate 5-phosphatase E (INPP5E) converts PI(4,5)P2 into PI4P and is required for proper ciliary function. Although Inpp5e mutations are associated with ciliopathies in humans
Jina Park +5 more
doaj +1 more source
HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly [PDF]
, 2019 HIV-1 Gag protein assembles at the plasma membrane of infected cells for viral particle formation. Gag targets lipids, mainly PI(4,5)P2, at the inner leaflet of this membrane.
Chojnacki, Jakub +6 more
core +1 more source
From Materials to Systems: Challenges and Solutions for Fast‐Charge/Discharge Na‐Ion Batteries
Advanced Energy Materials, EarlyView.This review systematically analyzes the key characteristics limiting the fast‐charge/discharge capability of Na‐ion batteries (SIBs) from a multi‐scale perspective encompassing electrode materials, the electrode‐electrolyte interface, and the system. Furthermore, it presents practical solution strategies for the fundamental issues arising at each scale,
Bonyoung Ku +5 more
wiley +1 more source
Cell ReportsSummary: Efficient synaptic vesicle (SV) recycling is essential for sustaining synaptic transmission. While the multiple roles of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in SV recycling are well documented, presynaptic regulation of ...
Tomofumi Yoshida +7 more
doaj +1 more source