Results 51 to 60 of about 11,050 (171)

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan   +10 more
wiley   +1 more source

Reasoned opinion on the modification of the existing MRL for aminopyralid in rape seed [PDF]

open access: yesEFSA Journal, 2012
<p>In accordance with Article 6 of Regulation (EC) No 396/2005, France, herewith referred to as the evaluating Member State (EMS), received an application from Dow AgroSciences to modify the existing MRL(s) for the active substance aminopyralid in ...
European Food Safety Authority
doaj   +1 more source

Ratiometric Mycotoxin Detection in Living Plants With Dual‐Emissive Nanosensors

open access: yesAdvanced Materials, Volume 38, Issue 47, 21 August 2026.
A minimally invasive microneedle patch integrates carbon dot‐embedded metal–organic frameworks as nanosensors to detect a key fungal toxin in living plants. The nanosensor produces a ratiometric fluorescence signal that enables early, non‐destructive diagnosis of fungal infection before visible symptoms, offering a new biomaterials‐based strategy for ...
Yuliang Li   +9 more
wiley   +1 more source

4-(Dimethylamino)pyridinium tetrachlorido(pyridine-2-carboxylato-&#954;2N,O)stannate(IV)

open access: yesActa Crystallographica Section E, 2012
The reaction of 4-(dimethylamino)pyridine, picolinic acid and stannic chloride yields the title salt, (C7H11N2)[SnCl4(C6H4NO2)], in which the SnIV atom is N,O-chelated by the picolinate ion in a cis-SnNOCl4 octahedral geometry.
Ezzatollah Najafi   +2 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

open access: yesAdvanced Science, Volume 13, Issue 45, 13 August 2026.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu   +18 more
wiley   +1 more source

Application of the Hydrogen‐Bond‐Mediated Aglycone Delivery (HAD) Reaction to the Synthesis of α‐ and β‐Linked 2‐Azido‐2‐deoxyglucosides

open access: yesChemistry – An Asian Journal, Volume 21, Issue 15, 14 August 2026.
H‐bond‐mediated aglycone delivery method has been applied to the synthesis of glucosamine glycosides. ABSTRACT Controlling stereoselectivity of glycosylation reactions remains one of the central challenges in synthetic carbohydrate chemistry. In this study, we explore the impact of O‐picoloyl (Pico) protecting group positioning on the stereoselectivity
Alessandra Damico   +2 more
wiley   +1 more source

Discovery of Ligands for the TNFR1 Extracellular Domain Using Fragment‐Based Drug Discovery

open access: yesChemMedChem, Volume 21, Issue 13, 14 July 2026.
The tumor necrosis factor receptor 1 (TNFR1) plays a major role in immunoregulation. We explored TNFR1 as a small‐molecule drug target using fragment‐based drug discovery. We found a picolinic acid fragment hit and characterized its binding mode in the extracellular domain of TNFR1.
Henri Chédotal   +6 more
wiley   +1 more source

Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MSs⃞

open access: yesJournal of Lipid Research, 2008
We have developed a highly sensitive and specific method for the analysis of serum sterol profiles. Sterols in 1 μl of dried serum were derivatized into picolinyl esters (3β-picolinate) and analyzed by liquid chromatography-tandem mass spectrometry (LC ...
Akira Honda   +8 more
doaj   +1 more source

The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive‐Like Behavior in Mice

open access: yesBrain and Behavior, Volume 16, Issue 7, July 2026.
Repetitive transcranial magnetic stimulation (rTMS) ameliorates chronic unpredictable mild stress (CUMS)‐induced depressive‐like behaviors in mice by modulating key tryptophan metabolism pathways, as evidenced by the restoration of serotonin levels and reduction of neuroactive metabolites.
Gao Yuan   +8 more
wiley   +1 more source

Pine Polyphenols Ameliorate Intestinal Barrier Damage via Regulating the Tryptophan Metabolites–AhR Pathway in a Pig Model

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Pine polyphenols (PP), a natural compound with potent antioxidant, anti‐inflammatory, and gut microbiota‐modulating activities, exhibit therapeutic potential for diet‐based therapies. However, their effects on the intestinal barrier function and microbiota, as well as the underlying mechanisms, remain unclear.
Jiong Gu   +6 more
wiley   +1 more source

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