Results 71 to 80 of about 6,282 (195)

Isomerization of α‐Pinene Oxide to Trans‐Pinocarveol

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
An operationally simple protocol for the selective isomerization of α‐pinene oxide (APO) to trans‐pinocarveol (TPC) is disclosed, which leverages inexpensive pyridinium‐halide organocatalysts to mitigate competing 1,2‐alkyl shifts. The scalability of this methodology is demonstrated on a decagram scale and catalyst‐recycling is validated through the ...
Emanuel Studer, Johanna Oortmann, Ryan Gilmour   +2 more
wiley   +1 more source

Synthesis, characterisation and luminescent properties of lanthanide-organic polymers with picolinic and glutaric acids [PDF]

Three new lanthanide(III) complexes (Ln = Sm, Tb and Eu) of picolinic and glutaric acid were prepared and characterised. The crystal structure of the complex [Sm(glu)(pic)- (H2O)2] (where Hpic and H2glu stand for picolinic and glutaric acid ...
Amaral, Vítor S., Carlos, Luís D., Ferreira, R. A. Sá, Girginova, Penka I., Klinowski, Jacek, Nogueira, Helena I. S., Paz, Filipe A. Almeida, Soares-Santos, Paula C. R., Trindade, Tito   +8 more
core   +1 more source

Mechanistic investigations of the asymmetric hydrosilylation of ketimines with trichlorosilane reveals a dual activation model and an organocatalyst with enhanced efficiency. [PDF]

, 2017
Structural probes used to help elucidate mechanistic information of the organocatalyzed asymmetric ketimine hydrosilylation have revealed a new catalyst with unprecedented catalytic activity, maintaining adequate performance at 0.01 mol% loading.
A. T. Reeder, Baudequin, Bonsignore, Braun, Cowley, El-Fayyoumy, F. Torri, Gautier, Gautier, Guizzetti, Guizzetti, H. Adams, Hagemann, Imamoto, Iwasaki, Jones, Jones, Malkov, Malkov, Malkov, Nakayama, Ngochindo, Onomura, Pei, Pei, S. Jones, Shirley, Sugiura, Wang, Warner, X. Li, Xiao, Zhang, Zheng   +33 more
core   +1 more source

Support Vector Machine Identification of Small Molecule Binders to an Understudied Allosteric Site of SARS‐CoV‐2 Mpro for Next‐Generation PROTAC‐Based Therapeutics

Archiv der Pharmazie, Volume 358, Issue 12, December 2025.
An SVM‐based ML model identified 180 potential SARS‐CoV‐2 Mpro inhibitors. MST experiments confirmed three high‐affinity binders, with one showing Kd = 2.8 ± 0.9 μM. These compounds are non‐competitive, suggesting binding to a novel allosteric site.
Enrico Mario Alessandro Fassi, Nedra Mekni, Marco Albani, Sabine Maehrlein, Annabelle Carolin Weldert, Tanja Schirmeister, Thierry Langer, Giovannf razioso   +7 more
wiley   +1 more source

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]

, 2016
Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran, Anderson, Katie, Berryhill, Grace, Chen, Ching-Hsien, Graef, Ashley, Hovey, Russell C, Kim, Jeffrey, Modiano, Jaime F, Sarver, Aaron L, Stewart, Benjamin, Trott, Josephine F, Uzal, Francisco, Weiss, Robert H, Wettersten, Hiromi   +13 more
core   +2 more sources

Plectranthus‐derived Abietanes as Protein Kinase C‐δ Activators: In Silico Design, Human Serum Albumin Interaction, and Stability Evaluation

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Cancer remains a major global health challenge. Among protein kinases (PKCs), PKC‐δ acts as a tumor suppressor in colon cancer and represents a valuable therapeutic target. Human serum albumin (HSA) is gaining attention as an efficient drug carrier, while Plectranthus spp. offers a rich source of bioactive compounds.
Vera M. S. Isca, Milan Nikolić, Nenad Filipović, Mattia Mori, Patricia Rijo   +4 more
wiley   +1 more source

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity [PDF]

, 2016
The free fatty acid receptor 4 (FFA4 or GPR120) has appeared as an interesting potential target for the treatment of metabolic disorders. At present, most FFA4 ligands are carboxylic acids that are assumed to mimic the endogenous long-chain fatty acid ...
Azevedo, Carlos, Christiansen, Elisabeth, Dunlop, Julia, Hansen, Steffen, Hudson, Brian, Kępczyńska, Malgorzata A., Milligan, Graeme, Shumpukade, Bharat, Stocker, Claire J., Ulven, Trond, Wargent, Edward T., Watterson, Kenneth   +11 more
core   +3 more sources

Green and Sustainable Chemistry Approaches on Azide‐Based Click Reactions in Polymer Science

Macromolecular Rapid Communications, Volume 46, Issue 23, December 5, 2025.
Click Chemistry, particularly the azide‐alkyne cycloaddition (AAC) reaction, has revolutionized polymer chemistry, enabling precise and efficient synthesis of advanced functional materials. With its high regioselectivity, mild reaction conditions, and versatility, AAC reactions align closely with the principles of Green and Sustainable Chemistry.
Hatice Mutlu, Bercis Pektas, C. Remzi Becer, Azra Kocaarslan   +3 more
wiley   +1 more source

Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology [PDF]

, 2015
Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders.
Jason C. O’Connor, Jennifer M. Parrott
core   +2 more sources

Addition of dianions of carboxylic acids to imines. Influence of the acid in the outcome of the reaction [PDF]

, 2009
The addition of different carboxylic acids dianions to N-benzylidenebenzeneamine have been studied. The outcome of the reaction depends on the acid. Saturated ones lead to β-aminoacids with good yields and syn-selectivity whereas α,β-unsaturated ones ...
Gil Grau, Salvador, Parra Alvarez, Margarita, Rodriguez Abad, Pablo   +2 more
core   +1 more source