Results 51 to 60 of about 6,282 (195)

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, Volume 26, Issue 4, Page 7-22, April 2026.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source

Pyrazinoic acid, the active form of the anti-tuberculosis drug pyrazinamide, and aromatic carboxylic acid analogs are protonophores

Frontiers in Molecular Biosciences
Pyrazinoic acid is the active form of pyrazinamide, a first-line antibiotic used to treat Mycobacterium tuberculosis infections. However, the mechanism of action of pyrazinoic acid remains a subject of debate, and alternatives to pyrazinamide in cases of
Fabio L. Fontes, Fabio L. Fontes, Steven A. Rooker, Jamie K. Lynn-Barbe, Michael A. Lyons, Debbie C. Crans, Debbie C. Crans, Dean C. Crick, Dean C. Crick   +8 more
doaj   +1 more source

Differential Analysis of IAA Anabolism Pathway Based on Bacillus cereus, Bacillus subtilis and Bacillus safensis Genome

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Three Bacillus species isolated from Platycladus orientalis rhizosphere in Taihang Mountains: Bacillus cereus has 3 IAA synthesis pathways (TAM, IAM, IPyA); Bacillus subtilis has IAM/IPyA; and Bacillus safensis only has IPyA (via whole‐genome sequencing).
Dongyue Hou, Xuejie Zhai, Kezhong Zhang, Jinteng Cui   +3 more
wiley   +1 more source

Investigation of Pyridine Carboxylic Acids in CM2 Carbonaceous Chondrites: Potential Precursor Molecules for Ancient Coenzymes [PDF]

The distribution and abundances of pyridine carboxylic acids (including nicotinic acid) in eight CM2 carbonaceous chondrites (ALH 85013, DOM 03183, DOM 08003, EET 96016, LAP 02333, LAP 02336, LEW 85311, and WIS 91600) were investigated by liquid ...
Callahan, Michael P., Dworkin, Jason P., Gerakines, Perry A., House, Christopher H., Smith, Karen E.   +4 more
core   +4 more sources

A Fragment-Based Approach for the Development of G-Quadruplex Ligands: Role of the Amidoxime Moiety [PDF]

, 2018
G-quadruplex (G4) nucleic acid structures have been reported to be involved in several human pathologies, including cancer, neurodegenerative disorders and infectious diseases; however, G4 targeting compounds still need implementation in terms of drug ...
Butovskaya, Elena, Doria, Filippo, Freccero, Mauro, Lena, Alberto, Nadai, Matteo, Pirota, Valentina, Richter, Sara N, Tassinari, Martina   +7 more
core   +2 more sources

Revisiting the Coordination Chemistry of Molybdenum(V): Novel Complexes with Pyrazinoate and Picolinate Ligands

Molbank
Reactions of (pyH)5[MoOCl4(H2O)]3Cl2 with picolinic and pyrazinoic acids yielded three new dinuclear molybdenum(V) complexes: (pyH)2[Mo2O4Cl2(pic)2]·CH3CN (1), (pyH)2[Mo2O4Cl2(pic)2]·CH3CH2CN (2) and (pyH)2[Mo2O4Cl2(pyraz)2]·CH3CN (3) (pic− = picolinate,
Barbara Modec, Nina Podjed Rihtaršič
doaj   +1 more source

Speciation of metal complexes of medicinal interest: relationship between solution equilibria and pharmaceutical properties [PDF]

, 2018
Biospeciation of essential and toxic metal ions, metal complexes with biological or medicinal activity are discussed in the paper in order to emphasize the importance of the distribution of metal ions in biological milieu.
Dömötör, Orsolya, Enyedy, Éva Anna, Jakusch, Tamás, Kiss, Tamás   +3 more
core   +2 more sources

Functional Interface Engineering Enables Selective Multicolor Upconversion in NaErF4@NaYF4 Core–Shell Nanocrystals

Advanced Physics Research, Volume 5, Issue 3, March 2026.
A functional interface engineering strategy is proposed to tune upconversion of NaErF4@NaYF4 core–shell nanocrystals by adjusting the amount of CF3COONa in the precursor during the shell growth. It is able to introduce controllable lattice defects at the core–shell interface to manipulate energy migration paths and non‐radiative transition of Er3 ...
Juan Ouyang, Ze Zhang, Minghua Shangguan, Haozhang Huang, Yuxuan Qiu, Songbin Liu, Junjun Tan, Xinyu Ye, Bo Zhou   +8 more
wiley   +1 more source

Carboxylic Solvents and O-Donor Ligand Effects on CH Activation by Pt(II) [PDF]

, 2006
We report on the design of more efficient C−H activation catalysts based on DFT calculations. The first examples of well-defined, N,O-donor ligated platinum complexes that are competent for fast C−H activation are detailed.
Goddard, William A., III, Mironov, Oleg A., Oxgaard, Jonas, Periana, Roy A., Young, Kenneth J. H., Ziatdinov, Vadim R.   +5 more
core   +1 more source

RELAXATION OF ISOLATED AORTA OF THE RABBIT BY PICOLINIC ACIDS [PDF]

British Journal of Pharmacology, 1977
When the isolated thoracic aorta of the rabbit was contracted with prostaglandin F2α, 5‐alkylpicolinic acids produced dose‐dependent relaxations. Picolinic acid, 2,5‐pyridinedicarboxylic acid and 5‐acetylpicolinic acid which do not have the 5‐alkyl residue failed to relax blood vessels.
M, Asano, H, Hidaka
openaire   +2 more sources