Results 51 to 60 of about 3,949 (150)

Structure‐Guided Surface Engineering of an Artificial Metallolyase for Highly Enantioselective Michael Addition

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
X‐ray visualization of copper‐binding modes revealed nonspecific surface metal sites that compromise stereoselectivity. Structure‐guided mutations suppressed background reactivity and enabled precise enantioselective control in the Michael addition, delivering up to 99% ee.
Saito Morikawa, Naoki Saegusa, Ryusei Matsumoto, Yoshitsugu Morita, Nobutaka Fujieda   +4 more
wiley   +1 more source

Impact of Gut Microbiota Metabolites on Serotonin Levels in Irritable Bowel Syndrome

Gut Medicine, Volume 2, Issue 2, Page 98-111, June 2026.
ABSTRACT Gut microbiota and their metabolites have been proposed as possible etiological factors in irritable bowel syndrome (IBS), and studies suggest that IBS is associated with impaired serotonin synthesis and release. Microbial metabolites are produced through biological pathways and enzymatic processes via gut microbiota.
Ning Gao, Yu Liu, Shaoxin Sun, Lulu Bin, Shanshan Li, Tao Yang, Winson Fu Zun Yang, Jiani Wu   +7 more
wiley   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Oregano essential oil enhanced body weight and well-being by modulating the HPA axis and 23-nordeoxycholic acid of cecal microbiota in Holstein steers under cold stress

Animal Microbiome
Background Prolonged exposure to cold stress in cattle increases basal energy consumption and impedes optimal production. Consequently, herds require adequate attention during cold, extended winters to alleviate cold stress and maintain profitability ...
Yongliang Huang, Siyu Cheng, Jinping Shi, Pengjia He, Yue Ma, Xu Zhang, Yongzhi Cao, Zhaomin Lei   +7 more
doaj   +1 more source

Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain. [PDF]

Chem Commun (Camb), 2016
Bremer PT, Xue S, Janda KD.
europepmc   +1 more source

Iron photocatalysis towards site-selective C(sp³)-H alkylation of glycines and peptides. [PDF]

Chem Sci
Panda SP, Prasad MS, Meher P, Reiser O, Murarka S.   +4 more
europepmc   +1 more source

Platinum Meets Pyridine: Affinity Studies of Pyridinecarboxylic Acids and Nicotinamide for Platinum-Based Drugs. [PDF]

Int J Mol Sci
Szefler B, Szupryczyński K, Czeleń P.
europepmc   +1 more source

Metabolic pathways linked to sarcopenia in the Bushehr Elderly Health Program: kynurenine, nicotinamide, B-vitamins, and sulfur amino acids. [PDF]

BMC Geriatr
Balajam NZ, Dehghanbanadaki H, Heshmat R, Mardani-Fard HA, Kasaeian A, Majidi Z, Bandarian F, Fahimfar N, Farzadfar F, Ostovar A, Nabipour I, Razi F, Shafiee G.   +12 more
europepmc   +1 more source

Serum Kynurenine Pathway Metabolites as Candidate Diagnostic Biomarkers for Pituitary Adenoma: A Case-Control Study. [PDF]

Medicina (Kaunas)
Oflas ND, Akbay Hİ, Alay M, Erdem M.
europepmc   +1 more source

Ferrous picolinate: a novel fortificant for sensitive dairy products. [PDF]

Front Nutr
Habeych E, Merinat S, Sanchez-Bridge B, Sabatier M, Galaffu N.   +4 more
europepmc   +1 more source