Results 41 to 50 of about 3,949 (150)

Ratiometric Mycotoxin Detection in Living Plants With Dual‐Emissive Nanosensors

Advanced Materials, Volume 38, Issue 47, 21 August 2026.
A minimally invasive microneedle patch integrates carbon dot‐embedded metal–organic frameworks as nanosensors to detect a key fungal toxin in living plants. The nanosensor produces a ratiometric fluorescence signal that enables early, non‐destructive diagnosis of fungal infection before visible symptoms, offering a new biomaterials‐based strategy for ...
Yuliang Li, Di Shen, Ziyang Huang, Suppanat Puangpathumanond, Calvin Thenarianto, Yue Zhao, Jolly Madathiparambil Saju, Rajani Sarojam, Dongmei Zhou, Tedrick Thomas Salim Lew   +9 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, Volume 13, Issue 45, 13 August 2026.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Revisiting the Coordination Chemistry of Molybdenum(V): Novel Complexes with Pyrazinoate and Picolinate Ligands

Molbank
Reactions of (pyH)5[MoOCl4(H2O)]3Cl2 with picolinic and pyrazinoic acids yielded three new dinuclear molybdenum(V) complexes: (pyH)2[Mo2O4Cl2(pic)2]·CH3CN (1), (pyH)2[Mo2O4Cl2(pic)2]·CH3CH2CN (2) and (pyH)2[Mo2O4Cl2(pyraz)2]·CH3CN (3) (pic− = picolinate,
Barbara Modec, Nina Podjed Rihtaršič
doaj   +1 more source

Application of the Hydrogen‐Bond‐Mediated Aglycone Delivery (HAD) Reaction to the Synthesis of α‐ and β‐Linked 2‐Azido‐2‐deoxyglucosides

Chemistry – An Asian Journal, Volume 21, Issue 15, 14 August 2026.
H‐bond‐mediated aglycone delivery method has been applied to the synthesis of glucosamine glycosides. ABSTRACT Controlling stereoselectivity of glycosylation reactions remains one of the central challenges in synthetic carbohydrate chemistry. In this study, we explore the impact of O‐picoloyl (Pico) protecting group positioning on the stereoselectivity
Alessandra Damico, Connor R. Mathus, Alexei V. Demchenko   +2 more
wiley   +1 more source

Discovery of Ligands for the TNFR1 Extracellular Domain Using Fragment‐Based Drug Discovery

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
The tumor necrosis factor receptor 1 (TNFR1) plays a major role in immunoregulation. We explored TNFR1 as a small‐molecule drug target using fragment‐based drug discovery. We found a picolinic acid fragment hit and characterized its binding mode in the extracellular domain of TNFR1.
Henri Chédotal, Katrine Povlsen, Dilip Narayanan, Charlotte H. Gotfredsen, Michael Gajhede, Anders Bach, Mads H. Clausen   +6 more
wiley   +1 more source

The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive‐Like Behavior in Mice

Brain and Behavior, Volume 16, Issue 7, July 2026.
Repetitive transcranial magnetic stimulation (rTMS) ameliorates chronic unpredictable mild stress (CUMS)‐induced depressive‐like behaviors in mice by modulating key tryptophan metabolism pathways, as evidenced by the restoration of serotonin levels and reduction of neuroactive metabolites.
Gao Yuan, Wang Zihao, Leng Yujia, Luan Rongrong, Zhao Xin, Yang Juanini, Liu Junchang, Feng Yuchao, Wang Peng   +8 more
wiley   +1 more source

Pine Polyphenols Ameliorate Intestinal Barrier Damage via Regulating the Tryptophan Metabolites–AhR Pathway in a Pig Model

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Pine polyphenols (PP), a natural compound with potent antioxidant, anti‐inflammatory, and gut microbiota‐modulating activities, exhibit therapeutic potential for diet‐based therapies. However, their effects on the intestinal barrier function and microbiota, as well as the underlying mechanisms, remain unclear.
Jiong Gu, Yuxuan Wang, Huilun Zhu, Xiong Deng, Wei Fang, Ming Liu, Bing Xia   +6 more
wiley   +1 more source

Omega-3 fatty acid supplementation affects tryptophan metabolism during a 12-week endurance training in amateur runners: a randomized controlled trial

Scientific Reports
The effects of long-term omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation during endurance training on tryptophan (Trp) metabolism and mental state of healthy individuals have not been evaluated so far.
Maja Tomczyk, Monika Bidzan-Wiącek, Jakub Antoni Kortas, Magdalena Kochanowicz, Zbigniew Jost, Helena L. Fisk, Philip C. Calder, Jędrzej Antosiewicz   +7 more
doaj   +1 more source

The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment

International Journal of Cancer, Volume 159, Issue 1, Page 122-143, 1 July 2026.
What's New? Many colorectal cancer survivors experience reduced health‐related quality of life (HRQoL), often lasting years after diagnosis. Healthy dietary patterns and even individual macro‐ and micronutrients, however, can potentially improve HRQoL.
Daniëlle D. B. Holthuijsen, Judith J. M. Rijnhart, Eline H. van Roekel, Martijn J. L. Bours, Per M. Ueland, Stéphanie O. Breukink, Maryska L. G. Janssen‐Heijnen, Joop L. Konsten, Eric T. P. Keulen, Adrian McCann, Stefanie Brezina, Biljana Gigic, Jennifer Ose, Matty P. Weijenberg, Simone J. P. M. Eussen   +14 more
wiley   +1 more source

Fecal Microbiota Transplantation From Patients With Social Anxiety Disorder Is Associated With General Anxiety‐Like Behavior and Gut Microbiota Alterations in Mice

Brain and Behavior, Volume 16, Issue 6, June 2026.
Fecal microbiota transplantation from patients with social anxiety disorder (SAD) into mice induces anxiety‐like behaviors, accompanied by gut microbiota alterations (increased Bacteroidota, decreased butyrate producers), downregulation of microbial metabolic pathways, and reduced plasma tryptophan, suggesting a causal role of gut dysbiosis in SAD ...
Yu‐Chao Feng, Xiao‐Xuan Liu, Huan Yu, Rui Liu, Ting‐Song Pang, Hua‐Ning Wang, Zheng‐Wu Peng   +6 more
wiley   +1 more source