Results 41 to 50 of about 6,282 (195)

Vanadyl complexes with dansyl-labelled dipicolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies [PDF]

, 2016
Vanadium complexes have been previously utilised as potent inhibitors of cysteine based phosphatases (CBPs). Herein, we present the synthesis and characterisation of two new fluorescently labelled vanadyl complexes (14 and 15) with bridged di-picolinic ...
Agostino Cilibrizzi, Anderie, Cirri, Costa Pessoa, Crans, Cuncic, Dyson, Gillian Whyte, Granier, He, Huyer, Inna Guterman, Juliet Collins, Kolmodin, Levina, Li, Lodyga-Chruscinska, Lok Hang Mak, Low, Lu, Lu, Lu, Mak, Makinen, Marina Fedorova, McLauchlan, McLauchlan, Mercey, Nakai, Ostman, Pessoa, Posner, Posner, Ramon Vilar, Robin Leatherbarrow, Rosivatz, Rudiger Woscholski, Sakurai, Salmeen, Schmid, Schmid, Scott, Seale, Thompson, Uto, Vanhaesebroeck, Walker, Wang, Xu, Yuan, Zhang, Zhang   +51 more
core   +1 more source

Crystal structure of picolinic acid hydrazide, C6H7N3O

Zeitschrift für Kristallographie - New Crystal Structures, 2006
Abstract C6H7N3O, monoclinic, C12/c1 (no. 15), a = 19.222(2) Å, b = 3.8987(4) Å, c = 18.115(2) Å, β = 107.095(2)°, V = 1297.6 Å3, Z = 8, Rgt(F) = 0.038, wRref(F2) = 0.122, T = 293 K.
Zareef M., Iqbal R., Zaidi J. H., Qadeer G., Wong W.-Y., Akhtar H.   +5 more
openaire   +3 more sources

The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment

International Journal of Cancer, Volume 159, Issue 1, Page 122-143, 1 July 2026.
What's New? Many colorectal cancer survivors experience reduced health‐related quality of life (HRQoL), often lasting years after diagnosis. Healthy dietary patterns and even individual macro‐ and micronutrients, however, can potentially improve HRQoL.
Daniëlle D. B. Holthuijsen, Judith J. M. Rijnhart, Eline H. van Roekel, Martijn J. L. Bours, Per M. Ueland, Stéphanie O. Breukink, Maryska L. G. Janssen‐Heijnen, Joop L. Konsten, Eric T. P. Keulen, Adrian McCann, Stefanie Brezina, Biljana Gigic, Jennifer Ose, Matty P. Weijenberg, Simone J. P. M. Eussen   +14 more
wiley   +1 more source

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]

, 1986
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Cox, O., Elo, Hannu, Kovacic, Peter, Lumme, Paavo, Ryan, Michael D.   +5 more
core   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii [PDF]

, 2015
As a part of our project aimed at searching new safe chemotherapeutic agents against parasitic diseases, several compounds structurally related to the antiparasitic agent WC-9 (4-phenoxyphenoxyethyl thiocyanate), which were modified at the terminal ...
Chao, Maria Noelia, Docampo, Roberto, Exeni Matiuzzi, Carolina, Li, Catherine, Moreno, Silvia N. J., Rodriguez, Juan Bautista, Storey, Melissa, Szajnman, Sergio Hernan   +7 more
core   +1 more source

A Distinct Tryptophan Metabolic Phenotype Marks Severe Fatigue in Quiescent Crohn's Disease

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background Fatigue is a common and debilitating symptom in inflammatory bowel disease (IBD), but its underlying mechanisms remain unclear. Altered tryptophan metabolism may contribute to fatigue. Tryptophan is metabolized through the kynurenine, serotonin, and indole pathway, involving host and microbial processes. We aimed to explore the link
Paula I. Metselaar, Mees J. van der Hoff, Naomi V. Wieser, Olaf Welting, Antoine Lefèvre, Camille Dupuy, Patrick Emond, Joep P. M. Derikx, Wouter J. de Jonge, Geert R. A. M. D'Haens, Anje A. te Velde, Mark Löwenberg, Mohammed Ghiboub   +12 more
wiley   +1 more source

Alleviative effect of Lueyang black-bone chicken liver peptides on dextran sodium sulfate-induced ulcerative colitis in mice

Journal of Functional Foods
Ulcerative colitis (UC), an inflammatory bowel disease with long-term medication side effects, requires safe therapies. Lueyang black-bone chicken liver peptides (BLP) were prepared by hydrolyzing its liver with 1 % alkaline protease for 1 h.
Jincheng Xi, Shanshan Wang, Ruixue Wang, Ling Wang, Hongzhao Lu, Tao Zhang, Wenxian Zeng   +6 more
doaj   +1 more source

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry. [PDF]

, 2019
BackgroundThe left internal thoracic artery (LITA) has been used as the first conduit of choice in coronary artery bypass grafting (CABG) because of excellent long-term patency and outcomes.
Cho, Joo Youn, Hwang, Ho Young, Jang, Cholsoon, Jang, In Jin, Kim, Andrew HyoungJin, Kim, Ji Seong, Kim, Ki Bong   +6 more
core  

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]

, 2014
Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona, Naudí, Alba, Pamplona, Reinald, Portero-Otín, Manuel, Ramírez-Núñez, Omar, Selman, Colin, Withers, Dominic J.   +6 more
core   +3 more sources