Results 31 to 40 of about 3,920 (149)

The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment

International Journal of Cancer, Volume 159, Issue 1, Page 122-143, 1 July 2026.
What's New? Many colorectal cancer survivors experience reduced health‐related quality of life (HRQoL), often lasting years after diagnosis. Healthy dietary patterns and even individual macro‐ and micronutrients, however, can potentially improve HRQoL.
Daniëlle D. B. Holthuijsen, Judith J. M. Rijnhart, Eline H. van Roekel, Martijn J. L. Bours, Per M. Ueland, Stéphanie O. Breukink, Maryska L. G. Janssen‐Heijnen, Joop L. Konsten, Eric T. P. Keulen, Adrian McCann, Stefanie Brezina, Biljana Gigic, Jennifer Ose, Matty P. Weijenberg, Simone J. P. M. Eussen   +14 more
wiley   +1 more source

Pyrazinoic acid, the active form of the anti-tuberculosis drug pyrazinamide, and aromatic carboxylic acid analogs are protonophores

Frontiers in Molecular Biosciences
Pyrazinoic acid is the active form of pyrazinamide, a first-line antibiotic used to treat Mycobacterium tuberculosis infections. However, the mechanism of action of pyrazinoic acid remains a subject of debate, and alternatives to pyrazinamide in cases of
Fabio L. Fontes, Fabio L. Fontes, Steven A. Rooker, Jamie K. Lynn-Barbe, Michael A. Lyons, Debbie C. Crans, Debbie C. Crans, Dean C. Crick, Dean C. Crick   +8 more
doaj   +1 more source

Structure‐Guided Surface Engineering of an Artificial Metallolyase for Highly Enantioselective Michael Addition

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
X‐ray visualization of copper‐binding modes revealed nonspecific surface metal sites that compromise stereoselectivity. Structure‐guided mutations suppressed background reactivity and enabled precise enantioselective control in the Michael addition, delivering up to 99% ee.
Saito Morikawa, Naoki Saegusa, Ryusei Matsumoto, Yoshitsugu Morita, Nobutaka Fujieda   +4 more
wiley   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Revisiting the Coordination Chemistry of Molybdenum(V): Novel Complexes with Pyrazinoate and Picolinate Ligands

Molbank
Reactions of (pyH)5[MoOCl4(H2O)]3Cl2 with picolinic and pyrazinoic acids yielded three new dinuclear molybdenum(V) complexes: (pyH)2[Mo2O4Cl2(pic)2]·CH3CN (1), (pyH)2[Mo2O4Cl2(pic)2]·CH3CH2CN (2) and (pyH)2[Mo2O4Cl2(pyraz)2]·CH3CN (3) (pic− = picolinate,
Barbara Modec, Nina Podjed Rihtaršič
doaj   +1 more source

Zn(OTf)2‐Catalyzed Dehydrocoupling of Terminal Alkynes with Diisopropylaminoborane: A Modular Route to Mono‐ and Dialkynylboranes

Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.
We report a Zn(OTf)2‐catalyzed dehydrocoupling of terminal alkynes with diisopropylaminoborane (DIPOB), which enables the selective synthesis of mono‐ and dialkynylboranes under mild conditions. This method provides a versatile platform for accessing stable tetracoordinate alkynylborons while effectively suppressing hydroboration side reactions.
Etienne Bequet‐Ermoy, Nicolas Zivic, Gabin Lalande, Laurent Chabaud, Mathieu Pucheault   +4 more
wiley   +1 more source

Picolinic and Isonicotinic Acids: A Fourier Transform Microwave Spectroscopy Study [PDF]

The Journal of Physical Chemistry A, 2014
The rotational spectra of laser ablated picolinic and isonicotinic acids have been studied using broadband chirped pulse (CP-FTMW) and narrowband molecular beam (MB-FTMW) Fourier transform microwave spectroscopies. Two conformers of picolinic acid, s-cis-I and s-cis-II, and one conformer of isonicotinic acid have been identified through the analysis of
Isabel, Peña, Marcelino, Varela, Vanina G, Franco, Juan C, López, Carlos, Cabezas, José L, Alonso   +5 more
openaire   +3 more sources

A Distinct Tryptophan Metabolic Phenotype Marks Severe Fatigue in Quiescent Crohn's Disease

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background Fatigue is a common and debilitating symptom in inflammatory bowel disease (IBD), but its underlying mechanisms remain unclear. Altered tryptophan metabolism may contribute to fatigue. Tryptophan is metabolized through the kynurenine, serotonin, and indole pathway, involving host and microbial processes. We aimed to explore the link
Paula I. Metselaar, Mees J. van der Hoff, Naomi V. Wieser, Olaf Welting, Antoine Lefèvre, Camille Dupuy, Patrick Emond, Joep P. M. Derikx, Wouter J. de Jonge, Geert R. A. M. D'Haens, Anje A. te Velde, Mark Löwenberg, Mohammed Ghiboub   +12 more
wiley   +1 more source

Why Osteosarcopenia Matters: Clinical and Investigative Implications

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Osteosarcopenia: Non‐pharmacological and pharmacological treatment strategies. ABSTRACT Background Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic,
Erik Luiz Bonamigo, Marcella Nora Maia, Renata Pinheiro Cavallaro de Oliveira, Régis Gemerasca Mestriner, Ivan Aprahamian, Gustavo Duque   +5 more
wiley   +1 more source

Omega-3 fatty acid supplementation affects tryptophan metabolism during a 12-week endurance training in amateur runners: a randomized controlled trial

Scientific Reports
The effects of long-term omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation during endurance training on tryptophan (Trp) metabolism and mental state of healthy individuals have not been evaluated so far.
Maja Tomczyk, Monika Bidzan-Wiącek, Jakub Antoni Kortas, Magdalena Kochanowicz, Zbigniew Jost, Helena L. Fisk, Philip C. Calder, Jędrzej Antosiewicz   +7 more
doaj   +1 more source