Results 31 to 40 of about 3,949 (150)

Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread

Nutrition Journal, 2011
Background The mechanism behind the lowered postprandial insulin demand observed after rye bread intake compared to wheat bread is unknown. The aim of this study was to use the metabolomics approach to identify potential metabolites related to amino acid
Mykkänen Hannu, Orešič Matej, Kolehmainen Marjukka, Aura Anna-Marja, Mattila Ismo, Katina Kati, Nordlund Emilia, Bondia-Pons Isabel, Poutanen Kaisa   +8 more
doaj   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, EarlyView.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

Linear Pentanuclear 3d–4f M‐Gd‐M‐Gd‐M Complexes Prepared From a One‐Pot Reaction Show Intramolecular Ferromagnetic Interactions (M  =  Cu, Ni, and Co)

European Journal of Inorganic Chemistry, EarlyView.
Using a multidentate ligand with two distinct coordination sites and a bridging coordination site, a series of novel linear pentanuclear complexes with alternately arranged 3d and 4f ions via a one‐pot reaction were synthesized. Cryomagnetic studies revealed the presence of intramolecular ferromagnetic interactions and their magnetic entropy changes ...
Takuya Shiga, Yukiko Okamoto, Nozomi Mihara, Masayuki Nihei   +3 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Advancing super‐resolution stimulated emission depletion microscopy with luminescent lanthanide nanocrystals

FlexMat, EarlyView.
The state‐of‐the‐art research advances and its cutting‐edge application in super resolution stimulated emission depletion technology based on luminescent lanthanide nanocrystals. Abstract Stimulated emission depletion (STED) microscopy overcomes the diffraction limit to reveal subcellular structures beyond the reach of conventional optical methods ...
Yaqi Chen, Tengfei Ma, Shuping Huang, Wei Guo, Yiming Wu   +4 more
wiley   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source

Alleviative effect of Lueyang black-bone chicken liver peptides on dextran sodium sulfate-induced ulcerative colitis in mice

Journal of Functional Foods
Ulcerative colitis (UC), an inflammatory bowel disease with long-term medication side effects, requires safe therapies. Lueyang black-bone chicken liver peptides (BLP) were prepared by hydrolyzing its liver with 1 % alkaline protease for 1 h.
Jincheng Xi, Shanshan Wang, Ruixue Wang, Ling Wang, Hongzhao Lu, Tao Zhang, Wenxian Zeng   +6 more
doaj   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Pyrazinoic acid, the active form of the anti-tuberculosis drug pyrazinamide, and aromatic carboxylic acid analogs are protonophores

Frontiers in Molecular Biosciences
Pyrazinoic acid is the active form of pyrazinamide, a first-line antibiotic used to treat Mycobacterium tuberculosis infections. However, the mechanism of action of pyrazinoic acid remains a subject of debate, and alternatives to pyrazinamide in cases of
Fabio L. Fontes, Fabio L. Fontes, Steven A. Rooker, Jamie K. Lynn-Barbe, Michael A. Lyons, Debbie C. Crans, Debbie C. Crans, Dean C. Crick, Dean C. Crick   +8 more
doaj   +1 more source