Results 101 to 110 of about 3,539,899 (186)

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Morphology of wound healing on Day 22, showing similarity among experimental groups (hematoxilyn and eosin—A, C, E; Picrosirius Red—B D, F)

, 2015
Morphology of wound healing on Day 22, showing similarity among experimental groups (hematoxilyn and eosin—A, C, E; Picrosirius Red—B D, F)
Josiane Ferraretto Shibuya (729742), Brunna Pileggi de Azevedo Sampaio (729741), Amanda Pires Souza (729739), Cristiano de Loura Santana (729735), Daniela de Fátima Teixeira Silva (729736), Raquel Agnelli Mesquita-Ferrari (729744), Renato Araujo Prates (729738), Sandra Kalil Bussadori (729743), Kristianne Porta Santos Fernandes (729745), Cristiane Miranda França (729746), Alessandro Melo Deana (729737), Mariana Teixeira Gomes (729740)   +11 more
core   +1 more source

Association of patient age with Picrosirius red collagen content in prostate tissues.

, 2014
The association of Picrosirius red collagen content and patient age at time of surgery was investigated in cohorts of BPH only tissues (TURP set), a combination of BPH and normal prostate tissue (TMA set [all patients]), and a subset of only normal ...
Tyler M. Bauman (638401), Wei Huang (36889), Chad M. Vezina (383839), William A. Ricke (279015), Tristan M. Nicholson (638402), Kevin W. Eliceiri (140016), Lisa L. Abler (638403)   +6 more
core   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Fibrotic remodeling in the NOD/ShiLtJ mouse model of Sjögren’s disease: insights from single-cell transcriptomics and AI-driven ECM quantification

Frontiers in Immunology
IntroductionSjögren's Disease (SjD) is an autoimmune disorder characterized by salivary gland hypofunction and lymphocytic infiltration, yet the contribution of fibrosis to glandular dysfunction remains unclear.MethodsWe evaluated the NOD/ShiLtJ mouse as
Jennifer M. Morrissey, Jennifer M. Morrissey, Deirdre A. Nelson, Li Chen, Mathieu Petitjean, Joey R. Tavarez, Joey R. Tavarez, Amber L. Altrieth-Flagg, Amber L. Altrieth-Flagg, Nicholas L. Moskwa, Renae Williams-Atkinson, Ben Fowler, Rafael Pena, Rafael Pena, Kennedi Weston, Kennedi Weston, Nikhita Kumar, Nikhita Kumar, Nathan Aist, Melinda Larsen, Melinda Larsen   +20 more
doaj   +1 more source

Picrosirius Red Staining: Revisiting Its Application to the Qualitative and Quantitative Assessment of Collagen Type I and Type III in Tendon. [PDF]

J Histochem Cytochem, 2021
López De Padilla CM, Coenen MJ, Tovar A, De la Vega RE, Evans CH, Müller SA.   +5 more
europepmc   +1 more source

Systemic pirfenidone treatment fails to mitigate fibrosis and compromises functional recovery in a porcine model of volumetric muscle loss

Experimental Physiology, EarlyView.
Abstract Repurposing clinically approved antifibrotic agents presents a potential near‐term therapeutic strategy to mitigate the extensive fibrotic scarring that follows severe volumetric muscle loss (VML) injury and inhibits functional recovery. We hypothesized that daily oral administration of pirfenidone, an FDA‐approved antifibrotic, would mitigate
Jessica M. Motherwell, Ondine Eken, Claudia E. Hernandez, Christopher L. Dearth, Stephen M. Goldman   +4 more
wiley   +1 more source

Quantitative nanohistological investigation of scleroderma: an atomic force microscopy-based approach to disease characterization

International Journal of Nanomedicine, 2017
Adam P Strange,1 Sebastian Aguayo,1 Tarek Ahmed,1 Nicola Mordan,1 Richard Stratton,2 Stephen R Porter,3 Susan Parekh,4 Laurent Bozec1 1Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 2Centre for Rheumatology and ...
Strange AP, Aguayo S, Ahmed T, Mordan N, Stratton R, Porter SR, Parekh S, Bozec L   +7 more
doaj  

Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend Four weeks of semaglutide treatment causes significant reductions in total body weight, fat mass, lean mass, and grip strength in mice with diet induced obesity. Mice treated with semaglutide lost a greater amount of total body weight and fat mass compared to mice fed fed a calorie matched diet.
S. Jeromson, B. Baranowski, M. Akcan, B. D. Waters, K. Eisner, A. Bellucci, S. Trang, A. Abolhassani, M. A. Tello‐Palencia, A. Schweitzer, B. Stefanska, C. J. Mitchell, David C. Wright   +12 more
wiley   +1 more source