Results 191 to 200 of about 12,266 (242)

Congenital aniridia: European COST action ANIRIDIA‐NET guidelines for diagnosis, management and care

open access: yesActa Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare ocular disorder affecting the majority of eye structures and can be associated with systemic manifestations. The main visible phenotypic characteristic is the partial or complete absence of the iris; however, foveal hypoplasia is a more frequent and reliable clinical sign. Other ocular comorbidities are associated
Davide Romano   +26 more
wiley   +1 more source

What can lithics tell us about food production during the transition to farming? Exploring harvesting practices and cultural changes during the neolithic in Southwest Asia: a view from Qminas (north‐western Syria)

open access: yesArchaeometry, EarlyView.
Abstract This study examines the continuity and change in harvesting practices between the Late Pre‐Pottery Neolithic B (LPPNB) and the Early Pottery Neolithic at Qminas, north‐western Levant, through a traceological analysis of flint sickles. By combining qualitative traceological analysis with quantitative functional approaches, we demonstrate that ...
Fiona Pichon   +3 more
wiley   +1 more source

Focal therapy using a novel cooled laser device for prostate cancer: early trial results

open access: yesBJU International, EarlyView.
Objectives To determine the short‐term oncological results and safety of the ProFocal Laser Therapy for Prostate Tissue Ablation (PFLT‐PC) trial, the first phase II clinical trial of ProFocal® (Medlogical Innovations, Sydney, Australia), a novel, cooled laser focal therapy (cLFT) device for prostate cancer (PCa) treatment. Patients and Methods Men with
Jonathan Kam   +17 more
wiley   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

open access: yesBritish Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman   +3 more
wiley   +1 more source

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey   +8 more
wiley   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

open access: yesThe FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal   +8 more
wiley   +1 more source

A wild‐caught rosy barb Pethia conchonius in a British urban pond underscores the need to prevent aquarium releases

open access: yesJournal of Fish Biology, EarlyView.
Abstract A specimen of rosy barb Pethia conchonius of 51 mm standard length, encountered in an urban pond in London, is reported. This small cyprinid is native to lakes and streams in subtropical regions of southern Asia and is commonly sold as an ornamental fish.
Peter J. Barry   +3 more
wiley   +1 more source

Non‐native pink salmon Oncorhynchus gorbuscha carcasses benefit native benthic macroinvertebrates

open access: yesJournal of Fish Biology, EarlyView.
Abstract The invasion of the North Atlantic by pink salmon Oncorhynchus gorbuscha has raised concerns regarding their impact on coastal rivers. Although the influence of marine‐derived nutrients from returning adult O. gorbuscha on rivers in their native range has received much attention, the ecological consequences of invasive O.
Hui Wei   +9 more
wiley   +1 more source

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